COMPARISON OF HEPATOPROTECTIVE ACTIVITY OF NISHA LAUHA (NL) AND NISHA LAUHA WITHOUT LAUHA BHASMA (NLWL) AGAINST CCL4 INDUCED HEPATOTOXICITY IN WISTAR RATS

Introduction: Many herbal drugs are used to treat liver diseases, but the dose of the herbal drug is high, and they have lesser palatability. An ideal medicine is a medicine that is effective, easy palatable and produces quick action in a low dose. It is possible by adding metals like Lauha (Iron) to the herbal drugs. Objective: To compare the hepatoprotective effect of Nisha Lauha (NL) and Nisha Lauha without Lauha Bhasma (NLWL) in experimental rats. Materials and methods: 40 rats were taken divided into five groups, and each group contained eight rats. Among these groups, four groups receive 0.2 ml of injection containing the 0.1 ml CCL4 plus 0.1 ml liquid paraffin given intraperitoneally for 28 days to induce Hepatotoxicity. Both Test groups received NL and NLWL at a dose of 45mg/kg bd. wt. and 450mg/kg bd. wt. respectively for 28 days. The standard group receives silymarin at a 100 mg/kg bd dose. wt. for 28 days by oral route. The hepatoprotective effect was analyzed using biochemical parameters and histopathological study of the liver. Results: Both the Test and standard groups do not show toxic effects against CCL4 induced hepatotoxicity and lower the dose of the herbal drug due to the addition of Lauha. Conclusion: The result suggests that both test group NL and NL without Lauha Bhasma shows the hepatoprotective activity as equivalent to standard drug silymarin. The addition of Lauha Bhasma to herbal drugs decreases the dose without affecting the drug’s efficacy against the hepatoprotective effect.

Herbal Drug Interactions

Use of complementary and alternative medicines (CAM) for preventive and therapeutic purposes has increased tremendously in the last two decades internationally. The manufacturers of these products are not required to submit proof of safety or efficacy to the Food and Drug Administration. As a result, the adverse effects and drug interactions associated with them are largely unknown. In this chapter, the author presents interactions of herbal medicines with other medicines (herbal or non-herbal). A large number of herbal drugs, including from single drug to a variety of mixtures have been used to treat kidney disorders. Herb-herb or herb drug interaction has been reported intensively during last decade, therefore it becomes important to keep an eye on the use of combination herbal therapy in order to avoid serious results because of interactions with each other. Due to the growing awareness about the interactions and side effects of herbal drugs/supplements over the past few years, regulatory bodies are working on these issues and pharmacopoeias are being developed for reference.

Preparation of Tablet from Naagdon Plant by Wet Granulation Method for Treatment of Excessive Bleeding in Piles

The objective of present study was to formulate and evaluate the tablets for piles with different combination of herbal drugs. Material and Method: The tablet for piles containing lactose and mannitol as diluent and containing natural drugs like naagdon which was prepared by wet granulation method. The wet and compressed formulations were subject to several evaluation parameters like appearance, thickness, weight variation, hardness and friability. Results: The results of all evaluation parameters of piles tablet were within the acceptable limit. Pre-compression studies of piles tablet show satisfactory results. The thickness, hardness, weight variation, and friability of pilestablet were found to in acceptable range. The in-vitro drug release of eugenol from optimised for treatment piles formulation was found to be 90.23%. Significant results were obtained from present study. Discussion: The finding of current investigation clearly found that the health promotion of the body could be done by piles

Guduchi is Powder Dosage Form is used in Treatment of Diabetics Mellitus

Guduchi is one of the most versatile rejuvenating herb, possessing numerous therapeutic attributes. Madhumehahara (Antidiabetic) properties of Guduchi are highly appreciated in Ayurveda and even in recent modern researches. Scattered information pertaining to antidiabetic role of Tinospora is accessible inAyurvedic literature and there is need to assemble it. Present review Present review encompasses indepth information of antidiabetic potential of Guduchi and its various dosage forms from Ayurvedic view and to understand the possible mechanism of its action in combating the complex pathology of diabetes. Over the centuries, herbs have served as a major source of medicines for prevention and treatment of diseases including diabetes mellitus. These herbs are getting more importance around the globe and many studies have provided safety and efficacy of such herbal drugs in different condition. Guduchi Tinospora cordifolia is reported as highly potent -antidiabetic herb in and Guduchi Satva (GS) is popularly used to treat . In the present study, GS prepared from the stem of T. cordifolia was evaluated for hypoglycemic and Antidibetic. GS was powder dissolve in distilled water and administered to oral route of powder dosage form. Present review encompasses (i) in-depth information of antidiabetic potential of Guduchi and its various dosage forms from Ayurvedic view and (ii) to understand the possible mechanism of its action in combating the complex pathology of diabetes. Keyword: Diabetes Mellitus, Guduchi, Madhumeha, Tinospora cordifolia.

Diagnostic Characterization of Powdered Herbal Drugs for their Identification & Authentification in Classical Unani Formulations

Diagnostic characters of seven powdered herbal drugs namely Anab-us Salab (fruit), Bekh-e-Sausan (root), Kaifal (stem bark), Kalijiri (fruit), Nankhwah (fruit), Tukhm-e-Khurfa (seed) and Turbud (Root) have been discussed in detail for their identification and authentification in classical unani formulations. The investigation includes correct botanical and vernacular names, family name, organoleptic studies, therapeutic uses, unani formulations containing these drugs, besides their microscopical studies that includes identification of various cells/tissues/cell contents along with their measurements. All these studies will serve as a reference standard to the academicians, researchers, plant chemists, TM students, health professionals and plant base pharmaceutical industries. Keywords: Diagnostic characterization, identification, authentification, powdered herbal drugs.

Comparative study the essential oil composition of flowers and leaves of Crataegus monogyna L.

The aim of the work was to obtain essential oil from the leaves and flowers of the genus Hawthorn Crataegus monogyna L. and study its component composition to justify the possibility of expanding the use of this herbal drugs in medicine. Materials and methods. The leaves and flowers of Сrataegus monogyna L., which were used to obtain essential oil, were harvested in the western region of Ukraine in 2019. The quantitative content of essential oil in the herbal drugs was determined by hydrodistillation. By used chromato-mass spectrometry method determined the component composition of essential oil of leaves and flowers of Сrataegus monogyna L. The obtained spectra were compared with the library of mass spectra NIST05 and WILEY 2007 with a total number of spectra over 470000 in combination with programs for identification AMDIS and NIST.Results. The essential oil of leaves and flowers of Сrataegus monogyna L. was obtained and its quantitative content was determined, which was 0.15±0.02 % for flowers and 0.11±0.03 % for leaves. By used chromato-mass spectrometric method in the essential oil of flowers of Сrataegus monogyna L. revealed 37 compounds, leaves – 33. In the essential oil of flowers found monoterpenoids, the content of which was 0.44 % of the total, triterpenoids 7.17 %, aromatic compounds 12.61 %. In the essential oil of leaves were found monoterpenoids 37.8 %, aromatic compounds 10.25 %, norterpenoids 3.62 %, sesquiterpenoids 4.02 %, diterpenoids 2.17 %, triterpenoids 5.08 %.Conclusions. Due to the defined component composition of the essential oil of flowers and leaves of Сrataegus monogyna L., we consider its use to create drugs of external action for the treatment of skin diseases of various etiologies caused by staphylococcal and fungal microflora.

Cardiac Glycosides – The Review of Remedies in congestive heart Failure

Congestive heart failure, occurs when our heart muscle doesn't pump blood as well as it must. Certain conditions, such as narrowed arteries in your heart (coronary artery disease) or high blood pressure, gradually leave your heart too weak or stiff to fill and pump efficiently. Herbal drugs like digitalis, squill, and stropanthus commonly find the treatment of heart diseases. Caridio active glycosides like having the purpurea glycosides A and B present in the herb of digitalis, glucoscillaren A and scillarenase having the squill and strophanthus having strophanthoside.

PHARMACEUTICAL AND PHYSIO-CHEMICAL STUDY OF SHILADHATRI YOGA (KALPIT)

Ayurveda is a time-tested science. It is based on universal principles of nature; in ancient times it is mainly flourished through the herbal drugs but later the drugs failed to conquer the difficult disease conditions. Hence humans started searching for alternate natural resources. In this search a separate discipline was emerged oriented towards use of metals, minerals, and animal and plant products, designated as Rasa Shastra. Later, it flourished and superseded the herbal medicines. In the classics they mention that one can make his own drug by using his knowledge for any disease condition. That’s why here new drug Shiladhatri yoga (Kalpit) is formed for use in the treatment of Diabetes.