scholarly journals Effects of Concentrated Growth Factor and Hyaluronic Acid in an Experimental Model of Acute Traumatic Tympanic Membrane Perforation

2021 ◽  
Vol 37 (4) ◽  
pp. 254-260
Author(s):  
Hüseyin Sarı ◽  
Yavuz Atar ◽  
Selma Şengiz Erhan ◽  
Ruslan Hummatov ◽  
Öykü İzel Başaran ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Growth Factor ◽  
Tympanic Membrane ◽  
Experimental Model ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation

Topical Application of Epidermal Growth Factor (EGF) to Changes in Tympanic Membrane Perforation Diameter

2018 ◽  
Vol 18 (4) ◽  
pp. 186-191 ◽  
Author(s):  
Riskiana Djamin ◽  
Raihanah Aziza ◽  
Sutji Pratiwi Rahardjo ◽  
Eka Savitri ◽  
Abdul Qadar Punagi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tympanic Membrane ◽  
Topical Application ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation ◽  
Epidermal Growth

Enhanced expression of hepatocyte growth factor in the healing of experimental acute tympanic membrane perforation

2015 ◽  
Vol 79 (7) ◽  
pp. 987-992 ◽  
Author(s):  
Maria Makuszewska ◽  
Magdalena Sokołowska ◽  
Elżbieta Hassmann-Poznańska ◽  
Izabela Bialuk ◽  
Bożena Skotnicka ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Tympanic Membrane ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation ◽  
Enhanced Expression ◽  
Hepatocyte Growth

Regeneration of the tympanic membrane using fibroblast growth factor-2

2018 ◽  
Vol 132 (06) ◽  
pp. 470-478 ◽  
Author(s):  
Z-C Lou ◽  
Z-H Lou ◽  
J Xiao
Keyword(s):  
Growth Factor ◽  
Success Rate ◽  
Tympanic Membrane ◽  
Fibroblast Growth Factor ◽  
Tympanic Membrane Perforation ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Tympanic Membrane Perforations ◽  
Membrane Perforation ◽  
Chronic Tympanic Membrane Perforation

AbstractObjectiveA systematic review was conducted to investigate the effectiveness of fibroblast growth factor-2 on the regeneration of tympanic membrane perforation.MethodsThe PubMed database was searched for relevant studies. Experimental studies, human randomised controlled trials, prospective single-arm studies and retrospective studies reporting acute and chronic tympanic membrane perforations in relation to two healing outcomes (success rate and closure time), were selected.ResultsAll 11 clinical studies investigating the effect of fibroblast growth factor-2 on traumatic tympanic membrane perforations in humans reported a success rate of 89.3–100 per cent, with a closure time of around 2 weeks. Three studies of fibroblast growth factor-2 combined with Gelfoam showed that the success rate of chronic tympanic membrane perforation was 83–98.1 per cent in the fibroblast growth factor-2 group, but 10 per cent in the gelatine sponge groups.ConclusionFibroblast growth factor-2 with or without biological material patching promotes regeneration in cases of acute and chronic tympanic membrane perforation, and is safe and efficient. However, the best dosage, application time and administration pathway of fibroblast growth factor-2 are still to be elucidated.

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