Topical Application of Epidermal Growth Factor (EGF) to Changes in Tympanic Membrane Perforation Diameter

2018 ◽  
Vol 18 (4) ◽  
pp. 186-191 ◽  
Author(s):  
Riskiana Djamin ◽  
Raihanah Aziza ◽  
Sutji Pratiwi Rahardjo ◽  
Eka Savitri ◽  
Abdul Qadar Punagi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tympanic Membrane ◽  
Topical Application ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation ◽  
Epidermal Growth

scholarly journals Treatment of tympanic membrane perforation with topical epidermal growth factor: progress towards clinical application

2021 ◽  
Vol 7 (5) ◽  
pp. 768
Author(s):  
Puneeth S. Nayak ◽  
Anil S. Harugop ◽  
Prashant H. Patil ◽  
Prasad T. V. R. K. ◽  
Lakshmi Goswami
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tympanic Membrane ◽  
Tympanic Membrane Perforation ◽  
Cost Effective Treatment ◽  
Membrane Perforation ◽  
Group A ◽  
Epidermal Growth ◽  
Group B ◽  
Chemical Cautery

<p class="abstract"><strong>Background:</strong> Chronic otitis media is a widespread disease of developing countries, especially of the lower socio-economic group. Medical cost in hospitals associated with tympanoplasty for treating CSOM is very high. Our study investigates the efficacy of epidermal growth factor along with chemical cautery in healing of chronic tympanic membrane perforation on an outpatient department (OPD) basis. Hence providing a cheaper and cost effective treatment alternative to the patients.</p><p class="abstract"><strong>Methods:</strong> A total number of 70 patients with signs of COM attending ENT OPD were selected. The patients were randomly assigned into 2 groups each with a sample size of 35. Otoendoscopy and pure tone audiometry was performed. Group A was treated with EGF with chemical cautery and group B was treated with only chemical cautery. Both groups were followed up after 15 days, one month and second month of the procedure in ENT outpatient clinic.</p><p class="abstract"><strong>Results:</strong> The success rate of these non-healing perforation was found to be significantly higher in group A (29 [82.86%]) compared with group B (17 [65.71%]) with P value of 0.0070*.</p><p class="abstract"><strong>Conclusions: </strong>This study shows a statistically significant result with topical application of epidermal growth factor in small to medium non-healing central tympanic membrane perforation. Due to the promising result of epidermal growth factor, it could be considered as office myringoplasty.  </p>

scholarly journals Penggunaan Tetes Telinga Serum Autologous dengan Amnion untuk Penutupan Perforasi Membran Timpani

2012 ◽  
Vol 1 (1) ◽  
Author(s):  
Hidayatul Fitria ◽  
Yan Edward
Keyword(s):  
Growth Factor ◽  
Tympanic Membrane ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Tympanic Membrane Perforation ◽  
Autologous Serum ◽  
Membrane Perforation ◽  
Epidermal Growth ◽  
Tgf Β1

Abstrak Latar Belakang: Gangguan pendengaran atau ketulian mempunyai dampak yang merugikan bagi penderita , keluarga, masyarakat maupun negara. Salah satu penyebab ketulian yang sering dijumpai adalah radang telinga tengah, terutama yang disertai perforasi membran timpani yang menetap. Penutupan perforasi membran timpani dapat dilakukan dengan operatif dan konservatif. Secara konservatif sudah banyak cara yang dilakukan. Salah satunya dengan mengkaustik tepi perforasi dengan menggunakan silver nitrat untuk membuat luka baru, kemudian digunakan amnion sebagai jembatan (bridge) dan faktor regulasi yang terdapat pada tetes telinga serum autologous. Tujuan: Untuk menjelaskan gambaran penggunaan amnion sebagai jembatan dan tetes telinga serum autologous sebagai faktor regulasi. Tinjauan pustaka: Penutupan perforasi membran timpani dapat dilakukan secara konservatif salah satunya dengan menggunakan tetes telinga serum autologous sebagai faktor regulator, amnion sebagai jembatan dan penggunaan silver nitrat pada tepi perforasi untuk membuat luka baru. Serum autologous memiliki asselerator pertumbuhan yaitu epidermal growth factor (EGF) , transforming growth factor β1 (TGF- β1) dan fibronektin. Asselerator pertumbuhan ini dapat kita temukan pada penyembuhan membran timpani normal. Sedangkan membran amnion adalah jaringan semi transparan tipis yang membentuk lapisan terdalam membran fetus dengan susunan membran basalis yang tebal dan jaringan stroma avaskuler. Membran amnion mempercepat pembentukan epitel normal dengan menekan pembentukan jaringan fibrosis. Sel epitel amnion memproduksi faktor pertumbuhan seperti fibroblast growth factor dan transforming growth factor beta. Faktor pertumbuhan akan membantu komunikasi antara epitel dan sel fibroblast stroma untuk menekan proliferasi dan diferensiasi jaringan fibrosis. Kesimpulan: Diperlukan tiga elemen pada penutupan perforasi membran timpani yaitu faktor regulasi, jembatan (bridge) dan membuat luka baru pada tepi perforasi. Kata kunci: tetes telinga serum autologous, membran amnion, perforasi membran timpani Abstract Background: Hearing loss or deafness have an adverse impact on patients, families, communities and the country. One cause of deafness that often met is middle ear inflammation, especially those with persistent tympanic membrane perforation. Closure of tympanic membrane perforation can be performed with operative and conservative. The conservatives have done with a lot of ways. One of them is cauterize edge of perforation by using silver nitrate to make a new wound, then used the amnion as a bridge and regulatory factors present in autologous serum eardrops. Objective: To describe the use of amnion as a bridge and autologous serum eardrops as a regulatory factor. Literature review: Closure of tympanic membrane perforation conservatively can be done either by using the autologous serum eardrops as a factor regulator, amnion as a bridge and the use of silver nitrate on the edge of the perforation to create a new wound. Autologous serum have asselator growth of Epidermal Growth Factor (EGF), Transforming Growth Factor β1 (TGF-β1) and fibronectin. Asselerator growth factor can be found on normal tympanic membrane healing. While the amniotic membrane is semi-transparant thin tissue that forms the deepest layer of fetal membranes with formation of a thick basement membrane and tissue stroma avaskuler. Amniotic membrane accelerate the formation of normal epithelial tissue by pressing the formation of fibrosis. Amniotic epithelial cells produce growth factors such as fibroblast growth factor and transforming growth factor beta. Growth factors will help the communication between epithelial and stromal fibroblast cells to suppress proliferation and differentiation of tissue fibrosis. Conclusion: It takes three elements on the closure of tympanic membrane perforation factor regulation, bridge and make new cuts on the edge of the perforation. Keywords: autologous serum eardrops, amnion membrane, tympanic membrane perforation

scholarly journals Repair of chronic tympanic membrane perforations with long-term epidermal growth factor

1995 ◽  
Vol 105 (12) ◽  
pp. 1300-1304 ◽  
Author(s):  
Douglas W. Dvorak ◽  
Greg Abbas ◽  
Tatar Ali ◽  
Sherman Stevenson ◽  
D. Bradley Welling
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tympanic Membrane ◽  
Tympanic Membrane Perforations ◽  
Epidermal Growth
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