<i>Effects of Epidermal Growth Factor-Loaded Radially Oriented Nano-patterned Patch on Chronic Tympanic Membrane Perforation</i>

2017 ◽  
Author(s):  
Kyoung-Je Jang ◽  
Hoon Seonwoo ◽  
Myoungchul Lee ◽  
Sangbae Park ◽  
Jongbeom Ku ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tympanic Membrane ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation ◽  
Chronic Tympanic Membrane Perforation ◽  
Epidermal Growth

Topical Application of Epidermal Growth Factor (EGF) to Changes in Tympanic Membrane Perforation Diameter

2018 ◽  
Vol 18 (4) ◽  
pp. 186-191 ◽  
Author(s):  
Riskiana Djamin ◽  
Raihanah Aziza ◽  
Sutji Pratiwi Rahardjo ◽  
Eka Savitri ◽  
Abdul Qadar Punagi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tympanic Membrane ◽  
Topical Application ◽  
Tympanic Membrane Perforation ◽  
Membrane Perforation ◽  
Epidermal Growth

scholarly journals Treatment of tympanic membrane perforation with topical epidermal growth factor: progress towards clinical application

2021 ◽  
Vol 7 (5) ◽  
pp. 768
Author(s):  
Puneeth S. Nayak ◽  
Anil S. Harugop ◽  
Prashant H. Patil ◽  
Prasad T. V. R. K. ◽  
Lakshmi Goswami
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tympanic Membrane ◽  
Tympanic Membrane Perforation ◽  
Cost Effective Treatment ◽  
Membrane Perforation ◽  
Group A ◽  
Epidermal Growth ◽  
Group B ◽  
Chemical Cautery

<p class="abstract"><strong>Background:</strong> Chronic otitis media is a widespread disease of developing countries, especially of the lower socio-economic group. Medical cost in hospitals associated with tympanoplasty for treating CSOM is very high. Our study investigates the efficacy of epidermal growth factor along with chemical cautery in healing of chronic tympanic membrane perforation on an outpatient department (OPD) basis. Hence providing a cheaper and cost effective treatment alternative to the patients.</p><p class="abstract"><strong>Methods:</strong> A total number of 70 patients with signs of COM attending ENT OPD were selected. The patients were randomly assigned into 2 groups each with a sample size of 35. Otoendoscopy and pure tone audiometry was performed. Group A was treated with EGF with chemical cautery and group B was treated with only chemical cautery. Both groups were followed up after 15 days, one month and second month of the procedure in ENT outpatient clinic.</p><p class="abstract"><strong>Results:</strong> The success rate of these non-healing perforation was found to be significantly higher in group A (29 [82.86%]) compared with group B (17 [65.71%]) with P value of 0.0070*.</p><p class="abstract"><strong>Conclusions: </strong>This study shows a statistically significant result with topical application of epidermal growth factor in small to medium non-healing central tympanic membrane perforation. Due to the promising result of epidermal growth factor, it could be considered as office myringoplasty.  </p>

Expression of Fibroblast Growth Factor Receptors 1–4 in Human Chronic Tympanic Membrane Perforation

ORL ◽  
2009 ◽  
Vol 71 (1) ◽  
pp. 67-70 ◽  
Author(s):  
Akinobu Kakigi ◽  
Aya Uchida ◽  
Masahiko Nishimura ◽  
Taizo Takeda ◽  
Setsuko Takeda ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tympanic Membrane ◽  
Fibroblast Growth Factor ◽  
Growth Factor Receptors ◽  
Tympanic Membrane Perforation ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors ◽  
Membrane Perforation ◽  
Chronic Tympanic Membrane Perforation

Regeneration of the tympanic membrane using fibroblast growth factor-2

2018 ◽  
Vol 132 (06) ◽  
pp. 470-478 ◽  
Author(s):  
Z-C Lou ◽  
Z-H Lou ◽  
J Xiao
Keyword(s):  
Growth Factor ◽  
Success Rate ◽  
Tympanic Membrane ◽  
Fibroblast Growth Factor ◽  
Tympanic Membrane Perforation ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Tympanic Membrane Perforations ◽  
Membrane Perforation ◽  
Chronic Tympanic Membrane Perforation

AbstractObjectiveA systematic review was conducted to investigate the effectiveness of fibroblast growth factor-2 on the regeneration of tympanic membrane perforation.MethodsThe PubMed database was searched for relevant studies. Experimental studies, human randomised controlled trials, prospective single-arm studies and retrospective studies reporting acute and chronic tympanic membrane perforations in relation to two healing outcomes (success rate and closure time), were selected.ResultsAll 11 clinical studies investigating the effect of fibroblast growth factor-2 on traumatic tympanic membrane perforations in humans reported a success rate of 89.3–100 per cent, with a closure time of around 2 weeks. Three studies of fibroblast growth factor-2 combined with Gelfoam showed that the success rate of chronic tympanic membrane perforation was 83–98.1 per cent in the fibroblast growth factor-2 group, but 10 per cent in the gelatine sponge groups.ConclusionFibroblast growth factor-2 with or without biological material patching promotes regeneration in cases of acute and chronic tympanic membrane perforation, and is safe and efficient. However, the best dosage, application time and administration pathway of fibroblast growth factor-2 are still to be elucidated.

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