Relationship Between Final Visual Acuity and Optical Coherence Tomography Findings in Patients with Diabetic Macular Edema Undergoing Anti-VEGF Therapy

Objective: to analyze the structural state of the central area of the retina in diabetic macular edema in the background anti-VEGF therapy.Methods. The study included 38patients (40eyes) with diabetic macular edema. All patients received anti-VEGF-ranibizumab therapy at a dose of 0.05ml. The results were analyzed after three intravitreal injections with 1month interval. We assessed visual acuity, morphological and anatomical structure of the macular area, the sensitivity of the retina and macular pigment optical densityResults. Analyzing optical density of the macular pigment we revealed a significant increase of all parameters in 73% of patients after the therapy. The average value of the optical density before treatment was at 0.102±0.01du, on the background of anti-VEGF-therapy this figure went up to 0.213±0.01 (p<0.05). According to the optical coherence to-mography average retinal thickness before treatment made 404.62±15.23μm, after the treatment – 300.91±6.43μm (р<0,05). When comparing data of optical coherence tomography and macular pigment optical density we revealed more pronounced decrease in the macular pigment optical density in the area of the retinal edema and a significant increase in the basic parameters on the background of the therapy.Conclusion. Anti-VEGF-therapy significantly improves visual acuity, the recovery profile of macular edema and reduces the zone in patients with diabetic macular edema.

Download Full-text

Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema

International Journal of Ophthalmology ◽

10.18240/ijo.2020.10.13 ◽

2020 ◽

Vol 13 (10) ◽

pp. 1592-1596

Author(s):

Hong-He Xia

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Multifocal Electroretinogram ◽

Optical Coherence

Download Full-text

Optical coherence tomography in diabetic macular edema: patterns and related risk factors

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v5i2.8727 ◽

2013 ◽

Vol 5 (2) ◽

pp. 190-194 ◽

Cited By ~ 4

Author(s):

Mohammadreza Ahmadpour-Baghdadabad ◽

Masoudreza Manaviat ◽

Ahmad Shojaoddiny-Ardekani

Keyword(s):

Risk Factors ◽

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Vision Loss ◽

Cross Sectional Study ◽

Optical Coherence ◽

Foveal Thickness ◽

Cross Sectional

Introduction: Diabetic Macular Edema (DME) is an important cause of vision loss in diabetic retinopathy. Optical Coherence Tomography (OCT) is a non-invasive modality that produces high-resolution images of retinal layers. Objective: To evaluate the prevalence of DME patterns and their association with risk factors and visual acuity. Materials and Methods: In this cross-sectional study, type 2 diabetics with macular edema referred to our center during a ten-month period underwent OCT. Patients with macular edema due to causes other than diabetes and with OCT images of improper quality were excluded from the study. Four distinct patterns were found in the OCT images. A questionnaire including age, sex, duration of diabetes, serum TG and cholesterol, HbA1c, BMI and visual acuity, as well as the findings of OCT images were filled for the subjects. Results: Eighty-six eyes from 46 patients were evaluated. The most and the least common patterns were sponge-like retinal swelling (SLRS) and posterior hyaloidal traction (PHT) found in 64.0% and 5.8% of the subjects, respectively. A sub-retinal fluid pattern was more common in males (p=0.011) and in patients with serum TG > 200mg/dl (p=0.037). There were significant associations between central foveal (r=0.45, p<0.001), nasal (r=0.35, p=0.001) and temporal (r=0.32, p=0.003) thicknesses with visual acuity. Moreover, the highest thickness (462.4±119.2μm) and also the worst visual acuity (1.0±0.5logMAR) pertained to the cystoid macular edema (CME) pattern. Conclusion: Our study showed that the most common OCT pattern of DME is the sponge-like retinal swelling, while posterior hyaloidal traction has the lowest prevalence. A higher foveal thickness and a lower visual acuity are seen in the CME pattern. Nepal J Ophthalmol 2013; 5(10): 190-194 DOI: http://dx.doi.org/10.3126/nepjoph.v5i2.8727

Download Full-text

Relationship between Optical Coherence Tomography Retinal Parameters and Visual Acuity in Diabetic Macular Edema

Ophthalmology ◽

10.1016/j.ophtha.2010.03.051 ◽

2010 ◽

Vol 117 (12) ◽

pp. 2379-2386 ◽

Cited By ~ 71

Author(s):

Tarek Alasil ◽

Pearse A. Keane ◽

Jared F. Updike ◽

Laurie Dustin ◽

Yanling Ouyang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Optical Coherence

Download Full-text

Relationship between Optical Coherence Tomography–Measured Central Retinal Thickness and Visual Acuity in Diabetic Macular Edema

Yearbook of Ophthalmology ◽

10.1016/s0084-392x(08)79095-6 ◽

2008 ◽

Vol 2008 ◽

pp. 148-149

Author(s):

J.F. Vander

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Retinal Thickness ◽

Central Retinal Thickness ◽

Optical Coherence

Download Full-text

Evaluation of vessel density in disorganization of retinal inner layers after resolved diabetic macular edema using optical coherence tomography angiography

PLoS ONE ◽

10.1371/journal.pone.0244789 ◽

2021 ◽

Vol 16 (1) ◽

pp. e0244789

Author(s):

Gilda Cennamo ◽

Daniela Montorio ◽

Federica Fossataro ◽

Claudia Fossataro ◽

Fausto Tranfa

Keyword(s):

Optical Coherence Tomography ◽

Visual Acuity ◽

Macular Edema ◽

Diabetic Macular Edema ◽

Negative Correlation ◽

Optical Coherence Tomography Angiography ◽

Significant Negative Correlation ◽

Vessel Density ◽

Optical Coherence ◽

Capillary Plexus

Purpose To evaluate the retinal vessel density (VD) in the macular region and the foveal avascular zone (FAZ) area using optical coherence tomography angiography (OCTA) in patients with and without disorganization of retinal inner layers (DRILs) after resolution of diabetic macular edema. Methods Thirty-seven eyes of 37 DRIL patients (mean age 63 ± 13.97 years), 30 eyes of 30 no DRIL patients and 35 eyes of 35 controls were enrolled in this study. We evaluated the VD in the macular region of superficial capillary plexus (SCP), deep capillary plexus (DCP) and FAZ area. Results DRIL and no DRIL groups showed decreased VD in SCP and DCP (p<0.05) and a larger FAZ area (p<0.001) compared to controls. However, DRIL patients revealed a statistically significant reduction in VD of SCP (p = 0.041) and a greater FAZ area (p<0.001) with respect to no DRIL patients. We found a significant negative correlation between the VD of the foveal SCP (r = -0.414, p = 0.011), foveal DCP (r = -0.358, p = 0.025) and best corrected visual acuity (BCVA) in DRIL group. Moreover there was a significant positive correlation between the FAZ area (r = 0.425, p = 0.034) and BCVA. Therefore, in presence of DRILs lower VD values of SCP and DCP and a larger FAZ area correlated with a worse visual acuity. In no DRILs group, there was a significant negative correlation between the VD of the foveal DCP and BCVA. Conclusion OCTA highlights the role of retinal vascular ischemia in the pathogenesis of DRILs. This parameter could represent an important functional predictive factor in diabetic patients.

Download Full-text