Quality of life in patients with Behcet's disease and Recurrent aphthous stomatitis

Background:Behçet’s Disease (BD) is a chronic, inflammatory, rheumatic disease that is characterized by mucocutaneous lesions and can be seen major organ involvement such as eyes, musculoskeletal system, gastrointestinal system and central nervous system. Impaired quality of life, aerobic capacity, respiratory function and life satisfaction, sleep disorders, depression, anxiety and fatigue are seen commonly in BD patients like the other rheumatic diseases. Considering that regular physical activity effects survival for patients and healthy people, it is important to determine the factors affecting physical activity level and exercise barriers.Objectives:The aim of this study is to investigate physical activity level and exercise barriers in patients with BD.Methods:45 patients were included in the study. Physical activity level, exercise barriers, fatigue, depression, pain, quality of life and aerobic capacity were evaluated with International Physical Activity Questionnaire (IPAQ), Exercise Barriers and Benefits Scale (EBBS), Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), Visual Analog Scale (VAS), Behçet’s Disease Quality of Life Questionnaire (BDQoL) and 6 minutes walk test, respectively. Spaerman’s Correlation Coefficient were used to investigate the relationships between exercise barriers and other parameters.Results:IPAQ demonstrated that 22 (48.8%) of the patients had low level physical activitiy. Additionally, physical activity levels significantly correlated with both exercise barriers (rho= -0.345) and exercise benefits (rho= 0.320) (p<0.05). BDQoL scores also correlated significantly with exercise barrier scores (rho= 0.338), (p<0.05). No significant relationships were observed for other parameters.Conclusion:Exercise and physical activity are of great importance because of its positive contribution to the musculoskeletal system for BD patients’ rehabilitation. Thinking of negative effects of physical inactivity, patients with Behçet disease should be encouraged to exercise. Also, reasons of physical inactivity should be investigated and treated.References:[1]Ilhan B, Can M, Alibaz-Oner F, Yilmaz-Oner S, Polat-Korkmaz O, Ozen G et al. Fatigue in patients with Behcet’s syndrome: relationship with quality of life, depression, anxiety, disability and disease activity. International journal of rheumatic diseases. 2018;21(12):2139-45.[2]Alder NM, Fisher M, Yazici Y. Behçet’s syndrome patients have high levels of functional disability, fatigue and pain as measured by a Multi-dimensional Health Assessment Questionnaire (MDHAQ). Clin Exp Rheumatol. 2008;26(Suppl 50):S110-3.Disclosure of Interests:None declared

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Quality of life and diet: A paired match study on Behçet’s disease

Mediterranean Journal of Nutrition and Metabolism ◽

10.3233/mnm-211571 ◽

2022 ◽

pp. 1-11

Author(s):

Murat Urhan ◽

Reci Meseri ◽

Fahrettin Oksel

Keyword(s):

Quality Of Life ◽

Behçet’S Disease ◽

Diet Quality ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Short Form ◽

Activity Levels ◽

Healthy Controls ◽

Behcet's Disease

BACKGROUND: It has been reported that the quality of life and diet quality in individuals with rheumatological diseases are poor and may adversely affect the course of the disease. OBJECTIVE: This study aims to compare the quality of life and diet of individuals with Behçet’s Disease (BD) compared to healthy controls. METHODS: This study was planned as a case-control study, and 60 adult patients with BD were compared with age (±1) and sex paired match healthy controls concerning the quality of life and diet. Diet quality was assessed using nutrient adequacy ratio (NAR) and the mean adequacy ratio (MAR) values calculated from 24 h dietary food recall and obesity was also evaluated by various anthropometric measurements. The Short Form-36 Health Survey (SF-36) was used to evaluate the quality of life (QoL). In addition, the 24-hour physical activities were recorded to calculate physical activity levels (PAL). Data were analyzed by SPSS 25.0 via paired sample t-test and McNemar (and McNemar-Bowkers) test. p < 0.05 was deemed significant. RESULTS: The findings showed that cases were more obese (p = 0.005), less physically active (p < 0.001), had lower QoL (p < 0.01 for all subscales) and had higher Beck depression scores (p = 0.001). Controls had higher means of energy (p < 0.001), CHO% (p = 0.025), fat% (p = 0.004), and fiber (p = 0.007) intake and mean MAR value (p < 0.001). CONCLUSIONS: Compared to healthy controls, patients with BD were more obese, had lower QoL and lower diet quality. Therefore, people with BD should be evaluated for comorbid diseases and be supported by health professionals, such as dietitians and psychologists.

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P0469 EVALUATION OF QUALITY OF LIFE IN BEHCET'S DISEASE

European Journal of Internal Medicine ◽

10.1016/s0953-6205(09)60489-1 ◽

2009 ◽

Vol 20 ◽

pp. S156-S157 ◽

Cited By ~ 1

Author(s):

Zeynep Erdogan ◽

Rukiye Pinar

Keyword(s):

Quality Of Life ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Behcet's Disease

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The impact of coping strategies on depression, anxiety, quality of life and disease activity in Behçet's disease

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2018.11.288 ◽

2019 ◽

Vol 29 ◽

pp. S166-S167

Author(s):

I.M. Atay ◽

I. Erturan

Keyword(s):

Quality Of Life ◽

Disease Activity ◽

Coping Strategies ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Behcet's Disease ◽

The Impact

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A composite index for determining the impact of oral ulcer activity in Behcet’s disease and recurrent aphthous stomatitis

Journal of Oral Pathology and Medicine ◽

10.1111/j.1600-0714.2009.00803.x ◽

2009 ◽

Vol 38 (10) ◽

pp. 785-791 ◽

Cited By ~ 21

Author(s):

G. Mumcu ◽

H. Sur ◽

N. Inanc ◽

U. Karacayli ◽

H. Cimilli ◽

...

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Composite Index ◽

Recurrent Aphthous Stomatitis ◽

Oral Ulcer ◽

Aphthous Stomatitis ◽

Behcet's Disease ◽

The Impact

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Common genetic susceptibility loci link PFAPA syndrome, Behçet’s disease, and recurrent aphthous stomatitis

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.2002051117 ◽

2020 ◽

pp. 202002051 ◽

Cited By ~ 1

Author(s):

Kalpana Manthiram ◽

Silvia Preite ◽

Fatma Dedeoglu ◽

Selcan Demir ◽

Seza Ozen ◽

...

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Risk Allele ◽

Behçet's Disease ◽

Periodic Fever ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Susceptibility Loci ◽

Behcet's Disease ◽

Pfapa Syndrome

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children. The disease appears to cluster in families, but the pathogenesis is unknown. We queried two European–American cohorts and one Turkish cohort (total n = 231) of individuals with PFAPA for common variants previously associated with two other oropharyngeal ulcerative disorders, Behçet’s disease and recurrent aphthous stomatitis. In a metaanalysis, we found that a variant upstream of IL12A (rs17753641) is strongly associated with PFAPA (OR 2.13, P = 6 × 10−9). We demonstrated that monocytes from individuals who are heterozygous or homozygous for this risk allele produce significantly higher levels of IL-12p70 upon IFN-γ and LPS stimulation than those from individuals without the risk allele. We also found that variants near STAT4, IL10, and CCR1-CCR3 were significant susceptibility loci for PFAPA, suggesting that the pathogenesis of PFAPA involves abnormal antigen-presenting cell function and T cell activity and polarization, thereby implicating both innate and adaptive immune responses at the oropharyngeal mucosa. Our results illustrate genetic similarities among recurrent aphthous stomatitis, PFAPA, and Behçet’s disease, placing these disorders on a common spectrum, with recurrent aphthous stomatitis on the mild end, Behçet’s disease on the severe end, and PFAPA intermediate. We propose naming these disorders Behçet’s spectrum disorders to highlight their relationship. HLA alleles may be factors that influence phenotypes along this spectrum as we found new class I and II HLA associations for PFAPA distinct from Behçet’s disease and recurrent aphthous stomatitis.

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