scholarly journals Changes in recipient body mass index for the first year after kidney transplantation are associated with intrapatient variability of tacrolimus concentration and long-term graft function

2020 ◽  
Vol 34 (1) ◽  
pp. S52-S52
Author(s):  
Hyunmin Ko ◽  
Chris Tae Young Chung ◽  
Hyo Kee Kim ◽  
Kwang Woo Choi ◽  
Ahram Han ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Kidney Transplantation ◽  
Body Mass ◽  
Graft Function ◽  
Tacrolimus Concentration ◽  
First Year ◽  
Intrapatient Variability

scholarly journals Changes in body mass index and outcomes after kidney transplantation: a single centre, retrospective, observational study

2019 ◽  
Author(s):  
Adam Arshad ◽  
James Hodson ◽  
Khalid Khalil ◽  
Adnan Sharif
Keyword(s):  
Body Mass Index ◽  
Kidney Transplantation ◽  
Body Mass ◽  
Geometric Mean ◽  
Graft Function ◽  
Estimating Equation ◽  
Kidney Transplant Recipients ◽  
Long Term Outcomes ◽  
Post Transplant

Abstract Background The aim of this study was to describe the changes in body mass index (BMI) after kidney transplantation and assess how this influences long-term outcomes. Methods Data were collected for all kidney transplant recipients between January 2007 and July 2016. Changes in BMI over the post-transplant period were modelled using a generalised estimating equation. The change in BMI from pre-transplantation to six months was then calculated for each patient. These were categorised into three groups: stable BMI (a change of ±1.5 kg/m2), BMI reduction and BMI increase (changes of >1.5 kg/m2), between which a range of outcomes were compared. Results Data was available for 1,344 patients, who had a geometric mean pre-transplant BMI of 27.3 kg/m2. This declined significantly (P<0.001), to a geometric mean of 25.6 kg/m2 one month after transplantation, before increasing and stabilising to pre-transplant levels by 36 months (geometric mean 27.2 kg/m2, P=0.522). The n=882 patients with BMI measurements at six months, were divided into groups of reduced (n=303), stable (n=388) and increased (n=131) BMI, relative to pre-transplantation levels. On multivariate analysis, 12-month creatinine levels were significantly higher in the BMI reduction cohort, with adjusted levels of 160.6 μmol/l, compared to 135.0 μmol/l in stable BMI. However, no significant associations were detected between six-month BMI change and patient survival, graft survival, incidence of post-transplant diabetes, cancer, or a range of clinical and histological outcomes (all P>0.05). Conclusions Our data demonstrates that BMI significantly reduces in the first month after kidney transplantation, before increasing to pre-transplant levels at 3-5 years. Furthermore, patients with decreasing BMI at six-months have impaired graft function in the long-term. These observations conflict with the existing literature and warrant further investigation.

Long-term experience of steroid-free pediatric renal transplantation: Effects on graft function, body mass index, and longitudinal growth

2013 ◽  
Vol 18 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Per Wittenhagen ◽  
Helle C. Thiesson ◽  
François Baudier ◽  
Erik B. Pedersen ◽  
Mette Neland
Keyword(s):  
Body Mass Index ◽  
Renal Transplantation ◽  
Body Mass ◽  
Graft Function ◽  
Longitudinal Growth ◽  
Pediatric Renal Transplantation ◽  
Long Term Experience

Long-Term Effect of Body Mass Index Changes on Graft Damage Markers in Patients After Kidney Transplantation

2016 ◽  
Vol 21 ◽  
pp. 626-631 ◽  
Author(s):  
Ilona Kurnatowska ◽  
Aneta Małyska ◽  
Kamila Wysocka ◽  
Katarzyna Mazur ◽  
Joanna Krawczyk ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Kidney Transplantation ◽  
Body Mass ◽  
Term Effect ◽  
Long Term Effect ◽  
Index Changes

Body mass index: short- and long-term impact on kidney transplantation

2015 ◽  
Vol 69 (11) ◽  
pp. 1357-1365 ◽  
Author(s):  
L. Orlic ◽  
I. Mikolasevic ◽  
I. Jakopcic ◽  
A. Grskovic ◽  
I. Jelic Pranjic ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Kidney Transplantation ◽  
Body Mass ◽  
Short And Long Term ◽  
Long Term Impact

Low Body Mass Index in Kidney Transplant Recipients: Risk or Advantage for Long-Term Graft Function?

2007 ◽  
Vol 39 (5) ◽  
pp. 1416-1420 ◽  
Author(s):  
O. Rettkowski ◽  
A. Wienke ◽  
A. Hamza ◽  
B. Osten ◽  
P. Fornara
Keyword(s):  
Body Mass Index ◽  
Kidney Transplant ◽  
Body Mass ◽  
Graft Function ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Low Body Mass Index

scholarly journals The temporal and long‐term impact of donor body mass index on recipient outcomes after kidney transplantation – a retrospective study

2019 ◽  
Vol 33 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Abhijit S. Naik ◽  
Yingchao Zhong ◽  
Ravi Parasuraman ◽  
Mona Doshi ◽  
Silas Norman ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Kidney Transplantation ◽  
Retrospective Study ◽  
Body Mass ◽  
Long Term Impact

High Donor Body Mass Index - a Predicting Factor for Inferior Long Term Results after Kidney Transplantation

2012 ◽  
Vol 94 (10S) ◽  
pp. 270
Author(s):  
A. Weissenbacher ◽  
M. Jara ◽  
H. Ulmer ◽  
C. Bösmüller ◽  
S. Schneeberger ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Kidney Transplantation ◽  
Body Mass ◽  
Long Term Results ◽  
Predicting Factor ◽  
High Donor

scholarly journals Intrapatient Variability in Tacrolimus Trough Levels Over 2 Years Affects Long-Term Allograft Outcomes of Kidney Transplantation

2021 ◽  
Vol 12 ◽  
Author(s):  
Yohan Park ◽  
Hanbi Lee ◽  
Sang Hun Eum ◽  
Hyung Duk Kim ◽  
Eun Jeong Ko ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Trough Level ◽  
First Year ◽  
High Group ◽  
Post Transplant ◽  
Intrapatient Variability ◽  
Allograft Loss ◽  
The Impact ◽  
Trough Levels

This study aimed to determine the impact of tacrolimus (TAC) trough level (C0) intrapatient variability (IPV) over a period of 2 years after kidney transplantation (KT) on allograft outcomes. In total, 1,143 patients with low immunologic risk were enrolled. The time-weighted coefficient variability (TWCV) of TAC-C0 was calculated, and patients were divided into tertile groups (T1: &lt; 24.6%, T2: 24.6%–33.7%, T3: ≥ 33.7%) according to TAC-C0-TWCV up to post-transplant 1st year. They were classified into the low/low, low/high, high/low, and high/high groups based on a TAC-C0-TWCV value of 33.7% during post-transplant 0–1st and 1st–2nd years. The allograft outcomes among the three tertile and four TAC-C0-TWCV groups were compared. The T3 group had the highest rate of death-censored allograft loss (DCGL), and T3 was considered an independent risk factor for DCGL. The low/low group had the lowest and the high/high group had the highest risk for DCGL. Moreover, patients with a mean TAC-C0 of ≥5 ng/ml in the high/high group were at the highest risk for DCGL. Thus, TAC-IPV can significantly affect allograft outcomes even with a high mean TAC-C0. Furthermore, to improve allograft outcomes, a low TAC-IPV should be maintained even after the first year of KT.

Recipient Body Mass Index Impact On Kidney Transplantation Outcomes: Results From a Long-Term Follow-Up Mediterranean Cohort.

2014 ◽  
Vol 98 ◽  
pp. 522
Author(s):  
J. Malheiro ◽  
I. Fonseca ◽  
L. Martins ◽  
M. Almeida ◽  
S. Pedroso ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Kidney Transplantation ◽  
Body Mass ◽  
Long Term Follow Up ◽  
Transplantation Outcomes

Body Mass Index in the First Year After Kidney Transplantation

2014 ◽  
Vol 46 (6) ◽  
pp. 1750-1752 ◽  
Author(s):  
B. Costa ◽  
L. Moratelli ◽  
L.B. Silva ◽  
A.C.M. Paiva ◽  
A.N. Silva ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Kidney Transplantation ◽  
Body Mass ◽  
First Year
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