scholarly journals Application of Artificial Heart for the Patients with End-stage Heart Failure(Totally Implantable Artificial Heart)

1999 ◽  
Vol 69 (7) ◽  
pp. 305-309
Author(s):  
M. HACHIDA ◽  
昌也 北村 ◽  
明彦 川合 ◽  
博 西田 ◽  
真弘 遠藤 ◽  
...  
Keyword(s):  
Heart Failure ◽  
Artificial Heart ◽  
End Stage Heart Failure ◽  
End Stage

The Biocompatibility Challenges in the Total Artificial Heart Evolution

2019 ◽  
Vol 21 (1) ◽  
pp. 85-110 ◽  
Author(s):  
Eleonora Dal Sasso ◽  
Andrea Bagno ◽  
Silvia T.G. Scuri ◽  
Gino Gerosa ◽  
Laura Iop
Keyword(s):  
Heart Failure ◽  
Artificial Heart ◽  
Comprehensive Analysis ◽  
Therapeutic Options ◽  
Total Artificial Heart ◽  
Final Treatment ◽  
End Stage Heart Failure ◽  
End Stage

There are limited therapeutic options for final treatment of end-stage heart failure. Among them, implantation of a total artificial heart (TAH) is an acceptable strategy when suitable donors are not available. TAH development began in the 1930s, followed by a dramatic evolution of the actuation mechanisms operating the mechanical pumps. Nevertheless, the performance of TAHs has not yet been optimized, mainly because of the low biocompatibility of the blood-contacting surfaces. Low hemocompatibility, calcification, and sensitivity to infections seriously affect the success of TAHs. These unsolved issues have led to the withdrawal of many prototypes during preclinical phases of testing. This review offers a comprehensive analysis of the pathophysiological events that may occur in the materials that compose TAHs developed to date. In addition, this review illustrates bioengineering strategies to prevent these events and describes the most significant steps toward the achievement of a fully biocompatible TAH.

Effect of a Total Artificial Heart on Adaptive Hormonal Responses in Humans with End-Stage Heart Failure

1989 ◽  
Vol 35 (3) ◽  
pp. 229-230 ◽  
Author(s):  
KEVIN D. MURRAY ◽  
P. DAVID MYEROWITZ ◽  
KIM M. WATSON ◽  
PATTY A. LOWE ◽  
LAURI K. KALANGES ◽  
...  
Keyword(s):  
Heart Failure ◽  
Artificial Heart ◽  
Total Artificial Heart ◽  
Hormonal Responses ◽  
End Stage Heart Failure ◽  
End Stage

Effect of a Total Artificial Heart on Adaptive Hormonal Responses in Humans with End-Stage Heart Failure

1989 ◽  
Vol 35 (3) ◽  
pp. 229-230
Author(s):  
KEVIN D. MURRAY ◽  
P. DAVID MYEROWITZ ◽  
KIM M. WATSON ◽  
PATTY A. LOWE ◽  
LAURI K. KALANGES ◽  
...  
Keyword(s):  
Heart Failure ◽  
Artificial Heart ◽  
Total Artificial Heart ◽  
Hormonal Responses ◽  
End Stage Heart Failure ◽  
End Stage

scholarly journals The Use of Total Artificial Heart With Example of Cases for End-Stage Heart Failure Therapy

2013 ◽  
Vol 62 (18) ◽  
pp. C45
Author(s):  
Serkan Ertugay ◽  
Özlem Balcıoğlu ◽  
Ayşen Yaprak Engin ◽  
Emrah Oğuz ◽  
Çağatay Engin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Artificial Heart ◽  
Total Artificial Heart ◽  
Heart Failure Therapy ◽  
End Stage Heart Failure ◽  
End Stage

scholarly journals A bioprosthetic total artificial heart for end-stage heart failure: Results from a pilot study

2018 ◽  
Vol 37 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Christian Latrémouille ◽  
Alain Carpentier ◽  
Pascal Leprince ◽  
Jean-Christian Roussel ◽  
Bernard Cholley ◽  
...  
Keyword(s):  
Heart Failure ◽  
Pilot Study ◽  
Artificial Heart ◽  
Total Artificial Heart ◽  
End Stage Heart Failure ◽  
End Stage

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

562 The clinical improvement of end-stage heart failure is not accompanied by correction of anemia

2006 ◽  
Vol 5 (1) ◽  
pp. 126-126
Author(s):  
S DRAKOS ◽  
E KALDARA ◽  
M BONIOS ◽  
D KARAGEORGOPOULOS ◽  
C PIERRAKOS ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Improvement ◽  
End Stage Heart Failure ◽  
End Stage
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