scholarly journals Addition of castor oil as a booster in colon capsule regimens significantly improves completion rates and polyp detection

2021 ◽  
Vol 12 (6) ◽  
pp. 103-112
Author(s):  
Serhiy Semenov ◽  
Mohd Syafiq Ismail ◽  
Fintan O'Hara ◽  
Sandeep Sihag ◽  
Barbara Ryan ◽  
...  
2020 ◽  
Author(s):  
S Semenov ◽  
R Atiyekeogbebe ◽  
MS Ismail ◽  
S Sihag ◽  
E McCarthy ◽  
...  

2013 ◽  
Vol 51 (08) ◽  
Author(s):  
MJ Farnbacher ◽  
H Krause ◽  
AF Hagel ◽  
M Raithel ◽  
MF Neurath ◽  
...  

Endoscopy ◽  
2021 ◽  
Author(s):  
Fanny E. R. Vuik ◽  
Stella A. V. Nieuwenburg ◽  
Sarah Moen ◽  
Cristiano Spada ◽  
Carlo Senore ◽  
...  

Abstract Introduction Primary colonoscopy and fecal immunochemical test (FIT) are the most commonly used colorectal cancer (CRC) screening modalities. Colon capsule endoscopy (CCE) might be an alternative. Data on the performance of CCE as a CRC screening tool in a screening population remain scarce. This is the first systematic review to provide an overview of the applicability of CCE as a CRC screening tool. Methods A systematic search was conducted of literature published up to September 2020. Studies reporting on CRC screening by second-generation CCE in an average-risk screening population were included. Results 582 studies were identified and 13 were included, comprising 2485 patients. Eight studies used CCE as a filter test after a positive FIT result and five studies used CCE for primary screening. The polyp detection rate of CCE was 24 % – 74 %. For polyps > 6 mm, sensitivity of CCE was 79 % – 96 % and specificity was 66 % – 97 %. For polyps ≥ 10 mm, sensitivity of CCE was 84 % – 97 %, which was superior to computed tomographic colonography (CTC). The CRC detection rate for completed CCEs was 93 % (25/27). Bowel preparation was adequate in 70 % – 92 % of examinations, and completion rates varied from 57 % to 92 %, depending on the booster used. No CCE-related complications were described. Conclusion CCE appeared to be a safe and effective tool for the detection of CRC and polyps in a screening setting. Accuracy was comparable to colonoscopy and superior to CTC, making CCE a good alternative to colonoscopy in CRC screening programs, although completion rates require improvement.


Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3367
Author(s):  
Ulrik Deding ◽  
Lasse Kaalby ◽  
Henrik Bøggild ◽  
Eva Plantener ◽  
Mie Kruse Wollesen ◽  
...  

Following incomplete colonoscopy (IC) patients often undergo computed tomography colonography (CTC), but colon capsule endoscopy (CCE) may be an alternative. We compared the completion rate, sensitivity and diagnostic yield for polyp detection from CCE and CTC following IC. A systematic literature search resulted in twenty-six studies. Extracted data included inter alia, complete/incomplete investigations and polyp findings. Pooled estimates of completion rates of CCE and CTC and complete colonic view rates (CCE reaching the most proximal point of IC) of CCE were calculated. Per patient diagnostic yields of CCE and CTC were calculated stratified by polyp sizes. CCE completion rate and complete colonic view rate were 76% (CI 95% 68–84%) and 90% (CI 95% 83–95%). CTC completion rate was 98% (CI 95% 96–100%). Diagnostic yields of CTC and CCE were 10% (CI 95% 7–15%) and 37% (CI 95% 30–43%) for any size, 13% (CI 95% 9–18%) and 21% (CI 95% 12–32%) for >5-mm and 4% (CI 95% 2–7%) and 9% (CI 95% 3–17%) for >9-mm polyps. No study performed a reference standard follow-up after CCE/CTC in individuals without findings, rendering sensitivity calculations unfeasible. The increased diagnostic yield of CCE could outweigh its slightly lower complete colonic view rate compared to the superior CTC completion rate. Hence, CCE following IC appears feasible for an introduction to clinical practice. Therefore, randomized studies investigating CCE and/or CTC following incomplete colonoscopy with a golden standard reference for the entire population enabling estimates for sensitivity and specificity are needed.


2018 ◽  
Vol 31 (2) ◽  
pp. 164-172 ◽  
Author(s):  
Naoki Ohmiya ◽  
Naoki Hotta ◽  
Shoji Mitsufuji ◽  
Masanao Nakamura ◽  
Takafumi Omori ◽  
...  

2020 ◽  
pp. 000313482095238
Author(s):  
Po-Hsien Wu ◽  
Nien-Ying Tsai, MD ◽  
Cheng-Wen Hsiao, MD ◽  
Shu-Wen Jao, MD ◽  
Yi-Chiao Cheng, MD

Background Reported learning curves of colonoscopy vary from 94 to 275 cases and focus on one-person colonoscopy. Our aim was to evaluate the learning curve of two-person non-sedation colonoscopy for trainees in a single tertiary care hospital. Patients and Methods We conducted a retrospective study in 1264 patients who underwent diagnostic or screening colonoscopies in a single institution from August 2012 to January 2013. Most of the patients (1174/1264) did not receive sedation during the procedure. All procedures were performed under two-person control. Two third-year residents who received previous colonoscopic training via a plastic model were the trainees. Results In comparison to the performance of 5 staff members, the colonoscopic outcomes showed no significant differences in the completion rates (77.2% vs. 79.8%, P = .382), average polyp numbers (.9 ± 1.7 vs. 1.0 ± 1.8, P = .453), polyp detection rates (43.5% vs. 46.3%, P = .434), or intubation lengths (96.4 ± 29.3 vs. 96.3 ± 26.7 cm, P = .939). The total procedure times for the 2 groups were 17.2 ± 10.6 minutes (trainees) and 12.9 ± 7.8 minutes (staff) ( P < .001). Conclusion Trainees achieved acceptable outcomes over an 81-97 case learning curve under a two-person non-sedation colonoscopy technique, an approach with potential as a transition to single-operator colonoscopy.


2021 ◽  
Vol 12 (4) ◽  
pp. 79-89
Author(s):  
Kota Takashima ◽  
Yoriaki Komeda ◽  
Toshiharu Sakurai ◽  
Sho Masaki ◽  
Tomoyuki Nagai ◽  
...  

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