Anti-cancer effects of Vernonia amygdalina: A systematic review

Purpose: To systematically review all the studies that have addressed the anti-cancer activities of the VA leaf extract in vitro to determine the strength of evidence of its anti-cancer effects and whether it can be used as an effective cancer therapy.Methods: The databases of Scopus, Science Direct, PubMed, Springer, and Directory of Open Access Journals were searched for relevant articles. Only articles published in the English language from January 2000 to November 2018 were selected for full-text retrieval and review, before being included in the final review.Results: From a total of 28 articles identified for full-text retrieval, only 17 fulfilled the inclusion criteria. The papers reviewed showed that VA decreases cell viability, inhibits DNA synthesis and causes DNA damage in cancer cells. VA also induces apoptosis and cell cycle arrest in cancer cells via gene regulation. All in all, there is evidence showing that VA possesses time- and concentration-dependent anti-cancer activity.Conclusion: The VA leaf extract has the potential to be developed into cancer therapeutics. However, more research is needed on its effect on normal cells before VA is developed into a cancer therapeutic. Keywords: Vernonia amygdalina, Anti-cancer effect, DNA damage, Apoptosis

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Is a Morphologically Complex Language Really that Complex in Full-Text Retrieval?

Advances in Natural Language Processing - Lecture Notes in Computer Science ◽

10.1007/11816508_42 ◽

2006 ◽

pp. 411-422 ◽

Cited By ~ 10

Author(s):

Kimmo Kettunen ◽

Eija Airio

Keyword(s):

Full Text ◽

Text Retrieval ◽

Full Text Retrieval

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A method of electric power enterprise project plan audit based on full-text retrieval technology

Automotive, Mechanical and Electrical Engineering ◽

10.1201/9781315210445-135 ◽

2017 ◽

pp. 723-726

Author(s):

Zijian Wang ◽

Yunhui Chen ◽

Hua Zhou ◽

Fuxiang Li ◽

Qian Chen ◽

...

Keyword(s):

Electric Power ◽

Full Text ◽

Text Retrieval ◽

Project Plan ◽

Power Enterprise ◽

Full Text Retrieval ◽

Electric Power Enterprise

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Stress responses as master keys to epigenomic changes in transcriptome and metabolome for cancer etiology and therapeutics

Molecular and Cellular Biology ◽

10.1128/mcb.00483-21 ◽

2021 ◽

Author(s):

Atanu Mondal ◽

Apoorva Bhattacharya ◽

Vipin Singh ◽

Shruti Pandita ◽

Albino Bacolla ◽

...

Keyword(s):

Stress Response ◽

Cancer Cells ◽

Stress Responses ◽

Current Knowledge ◽

Cancer Therapeutics ◽

Molecular Architecture ◽

Cancer Etiology ◽

Treatment Scenario ◽

Anti Cancer ◽

Novel Therapeutic Strategies

From initiation through progression, cancer cells are subjected to a magnitude of endogenous and exogenous stresses, which aid in their neoplastic transformation. Exposure to these classes of stress induces imbalance in cellular homeostasis and, in response, cancer cells employ informative adaptive mechanisms to rebalance biochemical processes that facilitate survival and maintain their existence. Different kinds of stress stimuli trigger epigenetic alterations in cancer cells, which leads to changes in their transcriptome and metabolome, ultimately resulting in suppression of growth inhibition or induction of apoptosis. Whether cancer cells show a protective response to stress or succumb to cell death depends on the type of stress and duration of exposure. A thorough understanding of epigenetic and molecular architecture of cancer cell stress response pathways can unveil a plethora of information required to develop novel anti-cancer therapeutics. The present view highlights current knowledge about alterations in epigenome and transcriptome of cancer cells as a consequence of exposure to different physicochemical stressful stimuli such as reactive oxygen species (ROS), hypoxia, radiation, hyperthermia, genotoxic agents, and nutrient deprivation. Currently, an anti-cancer treatment scenario involving the imposition of stress on target cancer cells is gaining traction to augment or even replace conventional therapeutic regimens. Therefore, a comprehensive understanding of stress response pathways is crucial for devising and implementing novel therapeutic strategies.

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