Onset and disappearance rates of gastroesophageal reflux symptoms in the Spanish population, and their impact on quality of life

Background & Aims: Gastroesophageal reflux disease (GERD) therapy is challenging and suppression of acid secretion or prokinetics do not cure all cases. Some drugs with protective action on the esophageal mucosa have been used alternatively or in association with proton pump inhibitors (PPIs) and/or prokinetics. The Romanian Society of Neurogastroenterology undertook an Evidence-Based analysis, from which this position paper evolved. Methods: We performed a systematic literature search in PubMed until October 2015, using the terms: sucralfate, guaiazulene, gaiazulene, dimethicone, alginate, antacids and gastroesophageal reflux. Forty-seven papers were included and analyzed. Several statements were elaborated regarding the use of these drugs in GERD. The evidence and recommendations were discussed between the authors. Results: There is evidence in the medical literature suggesting the benefit of these drugs in GERD. In patients with persistent or mild reflux symptoms antacids rapidly relieve heartburn. Alginate-antacid combination is superior both over placebo and antacids to treat mild reflux symptoms, and can be used to treat persistent reflux symptoms despite acid suppressant therapy. Sucralfate is superior over placebo in alleviating GERD symptoms and can be used as maintenance therapy. Guaiazulene-dimethicone improves the quality of life in patients with GERD. Conclusions: Drugs used to protect the esophageal mucosa against acid are useful in alleviating chronic heartburn, especially in patients with mild reflux symptoms. Abbreviations: CS: Chondroitin sulfate; DA: Double Action; EE : Erosive esophagitis ; GERD: Gastroesophageal reflux disease; HA: Hyaluronic acid; H2RA: Histamine 2 receptor antagonist; ITT: Intention to treat; IM: Irsogladine maleate; NERD: Non-erosive reflux disease; PPIs: Proton pump inhibitors; RCT: Randomized controlled trial; RDQ: Reflux disease questionnaire; QoL: Quality of life.

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P0492 GASTROESOPHAGEAL REFLUX SYMPTOMS AND QUALITY OF LIFE DO NOT CORRELATE WITH ESOPHAGEAL HISTOPATHOLOGY IN CHILDREN WITH EOSINOPHILIC ESOPHAGITIS

Journal of Pediatric Gastroenterology and Nutrition ◽

10.1097/00005176-200406001-00616 ◽

2004 ◽

Vol 39 (Supplement 1) ◽

pp. S243-S244 ◽

Cited By ~ 1

Author(s):

A. M. Stoltenberg ◽

H. Melin-Aldana ◽

B. Li ◽

A. F. Kagalwalla ◽

T. A. Sentongo ◽

...

Keyword(s):

Quality Of Life ◽

Gastroesophageal Reflux ◽

Eosinophilic Esophagitis ◽

Reflux Symptoms

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RA06.08: PATIENTS WITH FUNCTIONAL REFLUX SYMPTOMS DO NOT DIFFER SUBJECTIVELY FROM PATIENTS WITH GERD

Diseases of the Esophagus ◽

10.1093/dote/doy089.ra06.08 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 32-33

Author(s):

Sedat Ciftci ◽

Michael Weitzendorfer ◽

Dariya Kalcheva ◽

Lisa Manzenreiter ◽

Klaus Emmanuel ◽

...

Keyword(s):

Quality Of Life ◽

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Impedance Measurement ◽

Demeester Score ◽

Reflux Symptoms ◽

Significant Difference ◽

Functional Complaints ◽

Ph Metry

Abstract Background Patients with gastroesophageal reflux disease (GERD) often suffer greatly from their symptoms. The aim of this study was to determine if there is a difference in quality of life and gastrointestinal symptom complexes between patients with purely functional complaints and patients with objective GERD Methods Included were all patients with typical reflux symptoms who had GERD examination in 2017 at our department. All patients underwent high resolution manometry, 24-h ph-metry impedance measurement and gastroscopy. Quality of life was assessed using the Gastrointestinal Quality of Life Index (GIQLI) and gastrointestinal symptoms using a Symptom Checklist (SCL) assessing the severity and intensity of 14 different symptoms. Based on the results of the 24-h ph-metry impedance measurement, patients were divided into 2 groups. Patients with functional reflux symptoms and patients with GERD. These two groups were compared. Results Complete data was available in 162 patients, of whom 86 patients (52.2%) were objectively reflux sick (DeMeester score mean: 37.85, SD ± 29.11) and 76 patients (46.1%) had a normal DeMeester score (Mean: 7.01, SD ± 4.09). Between the two groups no significant difference in quality of life was found (mean GIQLI of GERD patients: 94.81, SD ± 22.40, and mean GIQLI of patients with functional reflux symptoms: 95.26, SD ± 20.33, P = 0.988).Furthermore no significant difference could be found in symptoms (mean general SCL score of reflux patients:46.97, SD ± 29.23, of patients with functional reflux symptoms: 48.03, SD ± 29.17, P = 0.827). Conclusion Patients with functional complaints suffer just as much from their symptoms as patients who are objectively reflux sick. A differentiation between gastroesophageal reflux disease and functional reflux symptoms is only possible by means of functional diagnostics. Disclosure All authors have declared no conflicts of interest.

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