Septohippocampal system

Stimulation of the septum and the hippocampus were found to elicit a great number of "wet-dog" shakes (WDS). Their occurrence is strongly related to the evocation and to the time course of the afterdischarges elicited by the stimulation. Morphine, apomorphine, diazepam, and antiserotoninergic drugs greatly reduce the incidence of these WDS but do not alter the afterdischarge duration. Based on electroencephalographic and pharmacological data we propose that WDS induced by stimulation of the septohippocampal system may share some common mechanisms with many other models inducing WDS and offer a useful method to study further the neuroanatomical substrate of this behavior.

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Atropine-Induced Convulsions in the Septohippocampal System. I. Effects of Cannula Position and Sex

Acta Medica (Hradec Kralove Czech Republic) ◽

10.14712/18059694.2019.177 ◽

1998 ◽

Vol 41 (3) ◽

pp. 131-134 ◽

Cited By ~ 2

Author(s):

Josef Herink

Keyword(s):

Wave Activity ◽

Local Administration ◽

Septal Nucleus ◽

Laboratory Rats ◽

Septohippocampal System ◽

Medial Septal Nucleus ◽

The Absolute ◽

Spike Wave

Effects of local administration of atropine into the medial septal nucleus (MSN) and dorsal septal nucleus (DSN) were tested in laboratory rats. Atropine administration led to the development of a spike/wave activity in the hippocampus as well as amygdala within 10 minutes. The frequency of spikes ranged in the absolute values from 20 to 25 spikes per minute in the case of atropine administration to MSN, while in the case of DSN it reached only about 16 spikes per minute. Spike/wave activity outlasted in the EEG record within 2 hours. The average incidence of spikes was somewhat lower in females than in males. A possible relation of the atropine-induced spike/wave activity to another kinds of limbic convulsions is discussed.

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Effect of Chronic Ethanol on the Septohippocampal System: A Role for Neurotrophic Factors?

Alcoholism Clinical and Experimental Research ◽

10.1111/j.1530-0277.1993.tb00719.x ◽

1993 ◽

Vol 17 (1) ◽

pp. 12-18 ◽

Cited By ~ 37

Author(s):

Don W. Walker ◽

Marieta B. Heaton ◽

Nancy Lee ◽

Michael A. King ◽

Bruce E. Hunter

Keyword(s):

Neurotrophic Factors ◽

Chronic Ethanol ◽

System A ◽

Septohippocampal System

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Coherence and Phase Analysis of Theta Oscillations in the Septohippocampal System during Generation of Convulsive Activity

Neuroscience and Behavioral Physiology ◽

10.1007/s11055-013-9716-1 ◽

2013 ◽

Vol 43 (2) ◽

pp. 214-218

Author(s):

I. V. Kabanova ◽

V. V. Sinelnikova ◽

I. Yu. Popova ◽

V. F. Kichigina ◽

R. R. Aliev

Keyword(s):

Phase Analysis ◽

Theta Oscillations ◽

Convulsive Activity ◽

Septohippocampal System

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Acute Ethanol Exposure Elevates Muscarinic Tone in the Septohippocampal System

Journal of Neurophysiology ◽

10.1152/jn.91072.2008 ◽

2010 ◽

Vol 103 (1) ◽

pp. 290-296 ◽

Cited By ~ 1

Author(s):

Mia Ericson ◽

Michelle A Sama ◽

Hermes H. Yeh

Keyword(s):

Direct Action ◽

Cholinergic Neurons ◽

Medial Septum ◽

Ethanol Exposure ◽

Neuronal Firing ◽

Firing Activity ◽

Diagonal Band ◽

Acute Ethanol ◽

Septohippocampal System ◽

Methyl Scopolamine

The septohippocampal system has been implicated in the cognitive deficits associated with ethanol consumption, but the cellular basis of ethanol action awaits full elucidation. In the medial septum/diagonal band of Broca (MS/DB), a muscarinic tone, reflective of firing activity of resident cholinergic neurons, regulates that of their noncholinergic, putatively GABAergic, counterparts. Here we tested the hypothesis that ethanol alters this muscarinic tone. The spontaneous firing activity of cholinergic and noncholinergic MS/DB neurons were monitored in acute MS/DB slices from C57Bl/6 mice. Exposing the entire slice to ethanol increased firing in both cholinergic and noncholinergic neurons. However, applying ethanol focally to individual MS/DB neurons increased firing only in cholinergic neurons. The differential outcome suggested different mechanisms of ethanol action on cholinergic and noncholinergic neurons. Indeed, with bath-perfused ethanol, the muscarinic antagonist methyl scopolamine prevented the increase in firing in noncholinergic, but not cholinergic, MS/DB neurons. Thus, the effect on noncholinergic neuronal firing was secondary to ethanol's direct action of acutely increasing muscarinic tone. We propose that the acute ethanol-induced elevation of muscarinic tone in the MS/DB contributes to the altered net flow of neuronal activity in the septohippocampal system that underlies compromised cognitive function.

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