Immanence is a key concept in Gilles Deleuze's thought. It emerges in 1968, in the book Expressionism in Philosophy: Spinoza and it is a focus until his last text. Immanence is a concept steeped in theological resonances, which disturbs Western metaphysics and politics. But, according to Deleuze, immanence is not really a concept, rather it is a ‘plan’. ‘The plan of immanence’ is the ‘prephilosophical’ working plan of philosophy. The point is that, according to Deleuze, philosophy cannot be understood only conceptually, although it begins with the creation of concepts. Here, rather, what is at stake is a prephilosophical origin of philosophy itself. This relationship between the plane of immanence and philosophy is the most important aspect that some of best-known exponents of contemporary Italian philosophy have inherited from Deleuze. The focus of this essay is on three expressions of the plane of immanence in the sense of Deleuze that have been developed in contemporary Italian Thought: the ‘constituent power’ of politics in Antonio Negri; the ‘impersonal’ in Roberto Esposito; and the ‘potentiality’ in Giorgio Agamben.