Mentorship and developmental networks

2019 ◽  
pp. 201-218
Author(s):  
Nikos Bozionelos
Keyword(s):  
Developmental Networks

scholarly journals H2O2 Induces Major Phosphorylation Changes in Critical Regulators of Signal Transduction, Gene Expression, Metabolism and Developmental Networks in Aspergillus nidulans

2021 ◽  
Vol 7 (8) ◽  
pp. 624
Author(s):  
Ulises Carrasco-Navarro ◽  
Jesús Aguirre
Keyword(s):  
Gene Expression ◽  
Protein Phosphorylation ◽  
Aspergillus Nidulans ◽  
Regulation Of Gene Expression ◽  
Antioxidant Response ◽  
Eukaryotic Cell ◽  
Cell Physiology ◽  
Tor Signaling ◽  
Developmental Networks ◽  
General Metabolism

Reactive oxygen species (ROS) regulate several aspects of cell physiology in filamentous fungi including the antioxidant response and development. However, little is known about the signaling pathways involved in these processes. Here, we report Aspergillus nidulans global phosphoproteome during mycelial growth and show that under these conditions, H2O2 induces major changes in protein phosphorylation. Among the 1964 phosphoproteins we identified, H2O2 induced the phosphorylation of 131 proteins at one or more sites as well as the dephosphorylation of a larger set of proteins. A detailed analysis of these phosphoproteins shows that H2O2 affected the phosphorylation of critical regulatory nodes of phosphoinositide, MAPK, and TOR signaling as well as the phosphorylation of multiple proteins involved in the regulation of gene expression, primary and secondary metabolism, and development. Our results provide a novel and extensive protein phosphorylation landscape in A. nidulans, indicating that H2O2 induces a shift in general metabolism from anabolic to catabolic, and the activation of multiple stress survival pathways. Our results expand the significance of H2O2 in eukaryotic cell signaling.

scholarly journals Reconstructing an epigenetic landscape using a genetic ‘pulling’ approach

2019 ◽  
Author(s):  
Michael Assaf ◽  
Shay Be’er ◽  
Elijah Roberts
Keyword(s):  
Simulated Data ◽  
Stable Gene ◽  
Epigenetic Landscape ◽  
Developmental Pathway ◽  
Developmental Networks ◽  
Genetic Switches ◽  
Fundamental Quantity ◽  
Developmental Dynamics ◽  
Stable Gene Expression ◽  
General Method

Cells use genetic switches to shift between alternate stable gene expression states, e.g., to adapt to new environments or to follow a developmental pathway. Conceptually, these stable phenotypes can be considered as attractive states on an epigenetic landscape with phenotypic changes being transitions between states. Measuring these transitions is challenging because they are both very rare in the absence of appropriate signals and very fast. As such, it has proven difficult to experimentally map the epigenetic landscapes that are widely believed to underly developmental networks. Here, we introduce a new nonequilibrium perturbation method to help reconstruct a regulatory network’s epigenetic landscape. We derive the mathematical theory needed and then use the method on simulated data to reconstruct the landscapes. Our results show that with a relatively small number of perturbation experiments it is possible to recover an accurate representation of the true epigenetic landscape. We propose that our theory provides a general method by which epigenetic landscapes can be studied. Finally, our theory suggests that the total perturbation impulse required to induce a switch between metastable states is a fundamental quantity in developmental dynamics.

scholarly journals Developmental Networks

2005 ◽  
Vol 138 (2) ◽  
pp. 548-549 ◽  
Author(s):  
Philip N. Benfey
Keyword(s):  
Developmental Networks

scholarly journals The Role of Developmental Networks in Building a Managerial Career

2020 ◽  
pp. 089484531990028
Author(s):  
Marianne Ekonen ◽  
Pia Heilmann
Keyword(s):  
21St Century ◽  
Male And Female ◽  
Developmental Networks ◽  
The People

The purpose of this study is to examine the role of developmental networks in a managerial career. We argue that the 21st-century managerial career is constructed in interaction with developmental networks. The people around one and the prevailing situation can either promote or restrict a person’s career. We search for answers to the questions of (1) what kinds of developmental networks exist and (2) how developmental networks affect managerial careers. We interviewed 16 managers, both male and female, in semistructured thematic interviews. We discovered six core narratives of developmental networks: enticers, recognizers, supporters, challengers, blockers, and demotivators. Our results highlight the importance of support and developmental networks in managerial careers.

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