Background: Post surgery syndrome resulting in persistent pain following lumbar spine surgery
is common. Speculated causes of post lumbar surgery syndrome include stenosis, degeneration of
adjacent segments, internal disc disruption, recurrent disc herniation, retained disc fragment, epidural or intraneural fibrosis, radiculopathy, and various other causes. Epidural injections are most
commonly used in post surgery syndrome. There is lack of evidence for the effectiveness of epidural injections in managing chronic low back pain with or without lower extremity pain secondary to
post surgery syndrome.
Study Design: A randomized, double-blind, equivalence trial.
Setting: An interventional pain management practice, a specialty referral center, a private practice
setting in the United States.
Objectives: To evaluate the effectiveness of caudal epidural injections in patients with chronic low
back and lower extremity pain after surgical intervention with post lumbar surgery syndrome.
Methods: Patients were randomly assigned to one of 2 groups; Group I patients received caudal epidural injections with local anesthetic (lidocaine 0.5%), whereas Group II patients received caudal epidural injections with 0.5% lidocaine 9 mL mixed with 1 mL of 6 mg non-particulate Celestone. Randomization was performed by computer-generated random allocation sequence by simple randomization.
Outcomes Assessment: Multiple outcome measures were utilized which included the Numeric Rating Scale (NRS), the Oswestry Disability Index 2.0 (ODI), employment status, and opioid intake
with assessment at 3 months, 6 months, and 12 months post-treatment.
Significant pain relief was described as 50% or more, whereas significant improvement in the disability score was defined as a reduction of 40% or more.
Results: Significant pain relief (≥ 50%) was recorded in 60% to 70% of the patients with no significant differences noted with or without steroid over a period of one-year. In addition, functional
assessment measured by the ODI also showed significant improvement with at least 40% reduction
in Oswestry scores in 40% to 55% of the patients. The average procedures per year were 3.4 with
an average total relief per year of 31.7 ± 19.10 weeks in Group I and 26.2 ± 18.34 weeks in Group
II over a period of 52 weeks.
Limitations: The results of this study are limited by the lack of a placebo group and the preliminary
report size of only 20 patients in each group.
Conclusion: Caudal epidural injections in chronic function-limiting low back pain in post surgery
syndrome without facet joint pain demonstrated effectiveness with over 55% of the patients showing improvement in functional status with significant pain relief in 60% to 70%.
Key words: Post lumbar surgery syndrome, post lumbar laminectomy syndrome, chronic low back
pain, epidural adhesions, epidural steroid injections, epidural fibrosis, recurrent disc herniation, spinal stenosis