scholarly journals Non-Convulsive Status Epilepticus at Pediatric Intensive Care Unit: A Single Center Experience

2021 ◽  
pp. 1-6
Author(s):  
Omnia F El-Rashiedy ◽  
◽  
Hanan M Ibrahim ◽  
Rania H Shatla ◽  
◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Status Epilepticus ◽  
Pediatric Intensive Care Unit ◽  
Pediatric Intensive Care ◽  
Convulsive Status Epilepticus ◽  
Eeg Monitoring ◽  
Single Center Experience ◽  
Abnormal Movements ◽  
Observational Cohort

Objective: Our study aims to estimate the incidence of non-convulsive status epilepticus (NCSE) in comatose children and to evaluate response to acute treatment with anticonvulsants. Material and methods: This is a prospective observational cohort study conducted in Pediatric Intensive Care Unit (PICU) of Ain-Shams University. Eighty patients presented with Glasgow coma scale (GCS) <8 and/or the presence of abnormal movements or vital sign fluctuations were enrolled in the study. All were subjected to EEG monitoring for at least 1 hour within 24 hours of presentation. Patients diagnosed as NCSE received anticonvulsant treatment and were reevaluated clinically and by EEG after 1 week. Results: Twenty four patients were diagnosed as NCSE (30%). EEG was normalized in 50% of patients after treatment. Conclusion: NCSE is possible to be under-recognized in the PICU settings because of the pleomorphic clinical features. Clinical suspension of NCSE and EEG monitoring for critically ill comatose children will improve their outcome

scholarly journals Convulsive status epilepticus in children

2017 ◽  
Vol 4 (5) ◽  
pp. 1861
Author(s):  
Hemachitra Jagannathan ◽  
Senthilkumar Palanivelu
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Status Epilepticus ◽  
Pediatric Intensive Care Unit ◽  
Tertiary Care ◽  
Pediatric Intensive Care ◽  
Outcome Data ◽  
Clinical Profile ◽  
Convulsive Status Epilepticus ◽  
Febrile Status Epilepticus

Background: Present study was undertaken to study the clinical profile, immediate outcome and possible risk factors for mortality in children with convulsive status epilepticus, admitted in pediatric intensive care unit in a tertiary care centre.Methods: This retrospective descriptive study included children between 1 month and 12 years of age admitted in pediatric intensive care unit with convulsive status epilepticus from April 2016 to March 2017. They were evaluated for their clinical presentation, laboratory parameters and immediate outcome.  Data were gathered on 52 patients with convulsive status epilepticus. Factors were analysed using univariate and multivariate analyses.Results: Among the 52 patients, the observations made were, common age group1-5years (51%), males (63%), wih fever (62%), idiopathic seizures (41.5%), febrile status epilepticus (22.7%) abnormal eeg (9.4%), leuocytosis (54.7%), csf abnormalities (33%), prolonged seizures (33%), need for intubation (31%), shock (29%), mortality (9.4%).Conclusions: Clinical profile of children with convulsive status epilepticus is described. Presence of shock, need for intubation and prolonged seizures are significantly associated with mortality. 

scholarly journals Use of recombinant human deoxyribonuclease in pediatric intensive care unit – a single-center experience

2022 ◽  
Vol 40 ◽  
Author(s):  
Daniel Meireles ◽  
Sofia Ribeiro Fernandes ◽  
Alzira Sarmento ◽  
Telma Barbosa ◽  
Manuel Ferreira Magalhães ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Pediatric Intensive Care Unit ◽  
Invasive Mechanical Ventilation ◽  
Pediatric Intensive Care ◽  
Convulsive Status Epilepticus ◽  
Single Center Experience ◽  
Radiologic Findings ◽  
Clinical Complications

ABSTRACT Objective: Dornase alfa (rhDNase) reduces the viscosity of purulent sputum in the lungs. The use in patients with cystic fibrosis (CF) is proven. However, the evidence of its applicability to other conditions is limited. This study aims to present the authors’ experience with the use of rhDNase in non-CF patients admitted to the Pediatric Intensive Care Unit (PICU). At the study center, rhDNase was used during flexible bronchoscopies in 24 cases, of which 20 (83%) had atelectasis and seven (29%) were admitted to PICU. Four patients (57%) were on invasive mechanical ventilation (MV). Case description: Two cases of daily rhDNase administration at PICU are presented: patient A was an 8-year-old boy admitted with septic shock and acute respiratory distress syndrome (ARDS). The patient required mechanical ventilation with aggressive settings and experienced several clinical complications. On D50, he started rhDNase treatment with an improvement in FiO2, PaCO2 and PaO2/FiO2 ratio according to radiologic findings. He was extubated on D23 of treatment. Patient B was a 17-month-old girl admitted with a convulsive status epilepticus who experienced respiratory complications (infectious and barotrauma) with ARDS, requiring aggressive ventilation. She initiated rhDNase treatment on D60. During the treatment an improvement in FiO2, PaO2/FiO2 ratio and a tendency of PaCO2 decrease were found. She had radiological improvement. No complications were described. Comments: RhDNase may be a helpful and safe tool to use in PICU prolonged intubated patients with ventilator-induced lung injury. Further studies are needed to assess and propose valid indications.

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