Microarray Data Pre-processing for Feature Selection and Classification

2021 ◽  
Vol 6 (1) ◽  
pp. 36
Author(s):  
Ipsita Paul
Author(s):  
B. Venkatesh ◽  
J. Anuradha

In Microarray Data, it is complicated to achieve more classification accuracy due to the presence of high dimensions, irrelevant and noisy data. And also It had more gene expression data and fewer samples. To increase the classification accuracy and the processing speed of the model, an optimal number of features need to extract, this can be achieved by applying the feature selection method. In this paper, we propose a hybrid ensemble feature selection method. The proposed method has two phases, filter and wrapper phase in filter phase ensemble technique is used for aggregating the feature ranks of the Relief, minimum redundancy Maximum Relevance (mRMR), and Feature Correlation (FC) filter feature selection methods. This paper uses the Fuzzy Gaussian membership function ordering for aggregating the ranks. In wrapper phase, Improved Binary Particle Swarm Optimization (IBPSO) is used for selecting the optimal features, and the RBF Kernel-based Support Vector Machine (SVM) classifier is used as an evaluator. The performance of the proposed model are compared with state of art feature selection methods using five benchmark datasets. For evaluation various performance metrics such as Accuracy, Recall, Precision, and F1-Score are used. Furthermore, the experimental results show that the performance of the proposed method outperforms the other feature selection methods.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Li-Hsin Cheng ◽  
Te-Cheng Hsu ◽  
Che Lin

AbstractBreast cancer is a heterogeneous disease. To guide proper treatment decisions for each patient, robust prognostic biomarkers, which allow reliable prognosis prediction, are necessary. Gene feature selection based on microarray data is an approach to discover potential biomarkers systematically. However, standard pure-statistical feature selection approaches often fail to incorporate prior biological knowledge and select genes that lack biological insights. Besides, due to the high dimensionality and low sample size properties of microarray data, selecting robust gene features is an intrinsically challenging problem. We hence combined systems biology feature selection with ensemble learning in this study, aiming to select genes with biological insights and robust prognostic predictive power. Moreover, to capture breast cancer's complex molecular processes, we adopted a multi-gene approach to predict the prognosis status using deep learning classifiers. We found that all ensemble approaches could improve feature selection robustness, wherein the hybrid ensemble approach led to the most robust result. Among all prognosis prediction models, the bimodal deep neural network (DNN) achieved the highest test performance, further verified by survival analysis. In summary, this study demonstrated the potential of combining ensemble learning and bimodal DNN in guiding precision medicine.


Author(s):  
Arunkumar Chinnaswamy ◽  
Ramakrishnan Srinivasan

The process of Feature selection in machine learning involves the reduction in the number of features (genes) and similar activities that results in an acceptable level of classification accuracy. This paper discusses the filter based feature selection methods such as Information Gain and Correlation coefficient. After the process of feature selection is performed, the selected genes are subjected to five classification problems such as Naïve Bayes, Bagging, Random Forest, J48 and Decision Stump. The same experiment is performed on the raw data as well. Experimental results show that the filter based approaches reduce the number of gene expression levels effectively and thereby has a reduced feature subset that produces higher classification accuracy compared to the same experiment performed on the raw data. Also Correlation Based Feature Selection uses very fewer genes and produces higher accuracy compared to Information Gain based Feature Selection approach.


2020 ◽  
pp. 707-725
Author(s):  
Sujata Dash

Efficient classification and feature extraction techniques pave an effective way for diagnosing cancers from microarray datasets. It has been observed that the conventional classification techniques have major limitations in discriminating the genes accurately. However, such kind of problems can be addressed by an ensemble technique to a great extent. In this paper, a hybrid RotBagg ensemble framework has been proposed to address the problem specified above. This technique is an integration of Rotation Forest and Bagging ensemble which in turn preserves the basic characteristics of ensemble architecture i.e., diversity and accuracy. Three different feature selection techniques are employed to select subsets of genes to improve the effectiveness and generalization of the RotBagg ensemble. The efficiency is validated through five microarray datasets and also compared with the results of base learners. The experimental results show that the correlation based FRFR with PCA-based RotBagg ensemble form a highly efficient classification model.


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