scholarly journals Proniosomes as a Drug Carrier for Transdermal Delivery of Ketoprofen

2020 ◽  
Vol 1 (6) ◽  
pp. 7-14
Author(s):  
Rajkumar Jampala ◽  
Vasantha Kasthuri ◽  
Sravan Kumar A
Keyword(s):  
Transdermal Delivery ◽  
Drug Carrier

scholarly journals Transfersome vs liposomes as drug delivery vehicle for the treatment of skin cancers

2019 ◽  
Vol 10 (3) ◽  
pp. 1795-1807
Author(s):  
Sivarajakumar Raahulan ◽  
Bharat Kumar Reddy Sanapalli ◽  
Sai Kiran SS. Pindiprolu ◽  
Veera Venkata Satyanarayana Reddy Karri
Keyword(s):  
Skin Cancer ◽  
Transdermal Delivery ◽  
Drug Carrier ◽  
Current Treatment ◽  
Delivery Vehicle ◽  
Preparation Methods ◽  
Regulatory Aspects ◽  
Skin Delivery ◽  
Skin Cancers ◽  
Target Effects

Skin cancer is one of the leading causes of cancer-related deaths worldwide. It is estimated that by 2030, there will be around 13.1million deaths can occur due to skin cancer. Current treatment of skin cancer includes surgery, radiation and chemotherapy. Chemo-resistance, off-target effects and poor bioavailability are the major challenges for currently available drugs for the treatment of skin cancer. Transfersomes is a novel, elastic vesicular drug carrier composed of phospholipids, surfactants and ethanol for enhanced transdermal delivery. This article we have reviewed about merits/demerits, liposomes vs transfersomes, preparation methods, characterization, mechanism of skin delivery, and application and regulatory aspects of transfersomes in treating various skin cancers.

Proniosomes as a drug carrier for transdermal delivery of ketorolac

2005 ◽  
Vol 59 (3) ◽  
pp. 485-490 ◽  
Author(s):  
Ibrahim A. Alsarra ◽  
A.A. Bosela ◽  
S.M. Ahmed ◽  
G.M. Mahrous
Keyword(s):  
Transdermal Delivery ◽  
Drug Carrier

Perspectives of Lipid-Based Drug Carrier Systems for Transdermal Delivery

2018 ◽  
Vol 35 (4) ◽  
pp. 331-367 ◽  
Author(s):  
Madhulika Pradhan ◽  
Shikha Srivastava ◽  
Deependra Singh ◽  
Shailendra Saraf ◽  
Swarnlata Saraf ◽  
...  
Keyword(s):  
Transdermal Delivery ◽  
Drug Carrier ◽  
Carrier Systems ◽  
Drug Carrier Systems

Proniosomes: the effective and efficient drug-carrier system

2020 ◽  
Vol 11 (2) ◽  
pp. 125-137 ◽  
Author(s):  
Swati Mittal ◽  
Amit Chaudhary ◽  
Anjali Chaudhary ◽  
Ankit Kumar
Keyword(s):  
Shelf Life ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Drug Carrier ◽  
Physical Stability ◽  
Dosage Forms ◽  
The Other ◽  
Carrier System ◽  
The Stability ◽  
Drug Carrier System

Niosomes, liposomes and proniosomes are the most abundantly used vesicular systems for the transdermal delivery of drugs. Proniosomes are nonhydrated niosomes, which, upon hydration, form niosomes. Various researches have proved the advantages of proniosomes over the other conventional dosage forms currently available in the market. Proniosomes overcome physical stability problems involved with other vesicular systems such as leaking, fusion and aggregation. The stability and shelf life of proniosomes especially have been found to be much better and prolonged in comparison to other vesicular systems such as liposomes. The present review has been written in an effort to bring yet another viewpoint from a different angle and curated to compile the latest updates in this highly attractive delivery system from today’s research point.

scholarly journals Ionic Liquid-In-Oil Microemulsions Prepared with Biocompatible Choline Carboxylic Acids for Improving the Transdermal Delivery of a Sparingly Soluble Drug

Pharmaceutics ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 392 ◽  
Author(s):  
Md. Rafiqul Islam ◽  
Md. Raihan Chowdhury ◽  
Rie Wakabayashi ◽  
Noriho Kamiya ◽  
Muhammad Moniruzzaman ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Transdermal Delivery ◽  
Drug Carrier ◽  
Skin Irritation ◽  
Skin Barrier ◽  
Biologically Active ◽  
Skin Barrier Function ◽  
Polar Phase ◽  
Sparingly Soluble Drug

The transdermal delivery of sparingly soluble drugs is challenging due to of the need for a drug carrier. In the past few decades, ionic liquid (IL)-in-oil microemulsions (IL/O MEs) have been developed as potential carriers. By focusing on biocompatibility, we report on an IL/O ME that is designed to enhance the solubility and transdermal delivery of the sparingly soluble drug, acyclovir. The prepared MEs were composed of a hydrophilic IL (choline formate, choline lactate, or choline propionate) as the non-aqueous polar phase and a surface-active IL (choline oleate) as the surfactant in combination with sorbitan laurate in a continuous oil phase. The selected ILs were all biologically active ions. Optimized pseudo ternary phase diagrams indicated the MEs formed thermodynamically stable, spherically shaped, and nano-sized (<100 nm) droplets. An in vitro drug permeation study, using pig skin, showed the significantly enhanced permeation of acyclovir using the ME. A Fourier transform infrared spectroscopy study showed a reduction of the skin barrier function with the ME. Finally, a skin irritation study showed a high cell survival rate (>90%) with the ME compared with Dulbecco’s phosphate-buffered saline, indicates the biocompatibility of the ME. Therefore, we conclude that IL/O ME may be a promising nano-carrier for the transdermal delivery of sparingly soluble drugs.

Solubility Enhancement of Poorly Soluble Drug Simvastatin by Solid Dispersion Technique

2016 ◽  
Vol 2 (2) ◽  
pp. 91-95
Author(s):  
Neelima Rani T ◽  
Pavani A ◽  
Sobhita Rani P ◽  
Srilakshmi N
Keyword(s):  
Dissolution Rate ◽  
Drug Carrier ◽  
Solid Dispersions ◽  
Aqueous Solubility ◽  
Onset Of Action ◽  
Kneading Method ◽  
Wetting Property ◽  
Poorly Soluble ◽  
Dispersion Technique ◽  
Low Solubility

This study aims to formulate solid dispersions (SDs) of Simvastatin (SIM) to improve the aqueous solubility, dissolution rate and to facilitate faster onset of action. Simvastatin is a BCS class II drug having low solubility & therefore low oral bioavailability. In the present study, SDs of simvastatin different drug-carrier ratios were prepared by kneading method. The results showed that simvastatin solubility & dissolution rate enhanced with polymer SSG in the ratio 1:7 due to increase in wetting property or possibly may be due to change in crystallinity of the drug.

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