Proniosomes: the effective and efficient drug-carrier system

2020 ◽  
Vol 11 (2) ◽  
pp. 125-137 ◽  
Author(s):  
Swati Mittal ◽  
Amit Chaudhary ◽  
Anjali Chaudhary ◽  
Ankit Kumar
Keyword(s):  
Shelf Life ◽  
Delivery System ◽  
Transdermal Delivery ◽  
Drug Carrier ◽  
Physical Stability ◽  
Dosage Forms ◽  
The Other ◽  
Carrier System ◽  
The Stability ◽  
Drug Carrier System

Niosomes, liposomes and proniosomes are the most abundantly used vesicular systems for the transdermal delivery of drugs. Proniosomes are nonhydrated niosomes, which, upon hydration, form niosomes. Various researches have proved the advantages of proniosomes over the other conventional dosage forms currently available in the market. Proniosomes overcome physical stability problems involved with other vesicular systems such as leaking, fusion and aggregation. The stability and shelf life of proniosomes especially have been found to be much better and prolonged in comparison to other vesicular systems such as liposomes. The present review has been written in an effort to bring yet another viewpoint from a different angle and curated to compile the latest updates in this highly attractive delivery system from today’s research point.

Experimental study on nuclear-targeted plasmid-based short hairpin RNA (ShRNA) to hypoxia inducible factor-1α (PshHIF-1α) PshHIF-1α nano-drug carrier system for breast cancer treatment in rats

2021 ◽  
Vol 11 (7) ◽  
pp. 1045-1050
Author(s):  
Gang Sun ◽  
Jin Zhang ◽  
Shuai Wu ◽  
Yun Liu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Flow Cytometry ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Apoptosis ◽  
Drug Carrier ◽  
Carrier System ◽  
Nano Drug Delivery ◽  
Drug Carrier System

This study was aimed at exploring the regulatory mechanism of auclear-targeted pshHIF-1α nano-drug carrier system (NPNCS) in the treatment of breast cancer in rats. MDA-MB-231 cell was cultured and DJ-1 and PTEN mRNA level was detected by qRT-PCR along with analysis of cell viability by CCK-8 and apoptosis by means of flow cytometry. The rats were assigned into control group, nuclear-targeted pshHIF-1α nanopharmaceutical system treatment group, and nuclear-targeted pshHIF-1α nano-pharmaceutical system+PTEN inhibitor SF1670 group, followed by analysis of cell proliferation by EdU staining, cell apoptosis by flow cytometry, and the levels of DJ-1, PTEN, and p-AKT. Compared with MDA-MB-231 cells treated with NPNCS, cells without intervention showed decreased PTEN and increased DJ-1 level. NPNCS induced cell apoptosis. Administration of nuclear-targeted pshHIF-1α nano-drug delivery system down-regulated DJ-1 and up-regulated PTEN. Combined treatment with SF1670 promoted p-AKT level and decreased the inhibitory effect of NPNCS on p-AKT level. In conclusion, the nuclear-targeted pshHIF-1α nano-drug delivery system down-regulated DJ-1 and exerted a tumor suppressor and pro-apoptotic effect, which wasrelated to p-AKT phosphorylation and up-regulation of PTEN.

Improving the genistein oral bioavailability via its formulation into the metal–organic framework MIL-100(Fe)

2021 ◽  
Vol 9 (9) ◽  
pp. 2233-2239
Author(s):  
Adrià Botet-Carreras ◽  
Cristina Tamames-Tabar ◽  
Fabrice Salles ◽  
Sara Rojas ◽  
Edurne Imbuluzqueta ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Metal Organic Framework ◽  
Drug Carrier ◽  
Aqueous Solubility ◽  
Carrier System ◽  
System P ◽  
Metal Organic ◽  
Drug Carrier System ◽  
Organic Framework

Despite the interesting chemopreventive, antioxidant and antiangiogenic effects of the natural bioflavonoid genistein (GEN), its low aqueous solubility and bioavailability make it necessary to administer it using a suitable drug carrier system.

Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

2008 ◽  
Vol 1140 ◽  
Author(s):  
Wolfgang Tremel ◽  
Mohammed Ibrahim Shukoor ◽  
Filipe Natalio ◽  
Muhammad Nawaz Tahir ◽  
Matthias Wiens ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Drug Carrier ◽  
Optical Detection ◽  
Cpg Odn ◽  
Carrier System ◽  
Functionalized Magnetic Nanoparticles ◽  
Selective Targeting ◽  
Target Molecules ◽  
Drug Carrier System

ABSTRACTMnO nanoparticles were conjugated to single stranded DNA (ssDNA), Cytosin-phosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different means of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles may serve as vehicles for the transport of target molecules into cells, while the fluorescent target ligand allows optical detection simultaneously.x

Studies on a bioerodible drug carrier system based on polyphosphazene Part I. Synthesis

1986 ◽  
Vol 3 (1-4) ◽  
pp. 143-154 ◽  
Author(s):  
C.W.J. Grolleman ◽  
A.C. de Visser ◽  
J.G.C. Wolke ◽  
H. van der Goot ◽  
H. Timmerman
Keyword(s):  
Drug Carrier ◽  
Carrier System ◽  
Drug Carrier System

Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes

Biomaterials ◽  
2005 ◽  
Vol 26 (15) ◽  
pp. 2723-2732 ◽  
Author(s):  
Sabine Balthasar ◽  
Kerstin Michaelis ◽  
Norbert Dinauer ◽  
Hagen von Briesen ◽  
Jörg Kreuter ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Carrier System ◽  
Gelatin Nanoparticles ◽  
Drug Carrier System
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