Avaliação in vitro e in vivo da atividade de frações e compostos isolados de Phyllanthus amarus contra o Schistosoma mansoni linhagem BH

2012 ◽  
Author(s):  
Claudineide Nascimento Fernandes Oliveira
Keyword(s):  
Schistosoma Mansoni ◽  
Phyllanthus Amarus

Niosomes for enhanced activity of praziquantel against Schistosoma mansoni: in vivo and in vitro evaluation

2018 ◽  
Vol 118 (1) ◽  
pp. 219-234 ◽  
Author(s):  
Hager S. Zoghroban ◽  
Samy I. El-Kowrany ◽  
Ibrahim A. Aboul Asaad ◽  
Gamal M. El Maghraby ◽  
Kholoud A. El-Nouby ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
In Vitro Evaluation ◽  
Enhanced Activity

The N-terminus moiety of the cystatin SmCys from Schistosoma mansoni regulates its inhibitory activity in vitro and in vivo

2004 ◽  
Vol 134 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Fabiana Carvalho Morales ◽  
Daniel Rodrigues Furtado ◽  
Franklin David Rumjanek
Keyword(s):  
Schistosoma Mansoni ◽  
Inhibitory Activity ◽  
N Terminus

scholarly journals Effect of phenyl vinyl sulphone cysteine protease inhibitor on Schistosoma mansoni: in vitro and in vivo experimental studies

2017 ◽  
Vol 41 (4) ◽  
pp. 1049-1058
Author(s):  
Manal Salah El-Din Mahmoud ◽  
Ayman Nabil Ibrahim ◽  
Abeer Fathy Badawy ◽  
Nourhan Mohamed Abdelmoniem
Keyword(s):  
Protease Inhibitor ◽  
Schistosoma Mansoni ◽  
Cysteine Protease ◽  
Experimental Studies ◽  
Cysteine Protease Inhibitor ◽  
Phenyl Vinyl

scholarly journals Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses

2009 ◽  
Vol 206 (8) ◽  
pp. 1673-1680 ◽  
Author(s):  
Bart Everts ◽  
Georgia Perona-Wright ◽  
Hermelijn H. Smits ◽  
Cornelis H. Hokke ◽  
Alwin J. van der Ham ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Human Monocyte ◽  
Potent Inducer ◽  
T Helper 2 ◽  
Mediated Effects ◽  
Reporter Mice ◽  
Th2 Polarization ◽  
Th2 Responses

Soluble egg antigens of the parasitic helminth Schistosoma mansoni (S. mansoni egg antigen [SEA]) induce strong Th2 responses both in vitro and in vivo. However, the specific molecules that prime the development of Th2 responses have not been identified. We report that omega-1, a glycoprotein which is secreted from S. mansoni eggs and present in SEA, is capable of conditioning human monocyte-derived dendritic cells in vitro to drive T helper 2 (Th2) polarization with similar characteristics as whole SEA. Furthermore, using IL-4 dual reporter mice, we show that both natural and recombinant omega-1 alone are sufficient to generate Th2 responses in vivo, even in the absence of IL-4R signaling. Finally, omega-1–depleted SEA displays an impaired capacity for Th2 priming in vitro, but not in vivo, suggesting the existence of additional factors within SEA that can compensate for the omega-1–mediated effects. Collectively, we identify omega-1, a single component of SEA, as a potent inducer of Th2 responses.

scholarly journals In vitro and in vivo anthelmintic activity of (−)-6,6′-dinitrohinokinin against schistosomula and juvenile and adult worms of Schistosoma mansoni

Acta Tropica ◽  
2015 ◽  
Vol 149 ◽  
pp. 195-201 ◽  
Author(s):  
Ana C. Pereira ◽  
Márcio L.A. e Silva ◽  
Julia Medeiros Souza ◽  
Rosangela S. de Laurentiz ◽  
Vanderlei Rodrigues ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Anthelmintic Activity

scholarly journals Differences between in vitro and in vivo obtained schistosomules

1990 ◽  
Vol 32 (2) ◽  
pp. 84-85 ◽  
Author(s):  
Alan L. Melo ◽  
Conceição R. S. Machado ◽  
Leógenes H. Pereira
Keyword(s):  
Cell Adhesion ◽  
Schistosoma Mansoni ◽  
Peritoneal Cavity ◽  
Adherent Cells

The injection of cercariae of Schistosoma mansoni into the peritoneal cavity of naive mice induces cell adhesion to these larvae, and this adherence sharply decreases when the infecting larva changes to schistosomule. This procedure was used to detect differences between schistosomules obtained in vivo and in vitro. Reinoculation of schistosomules obtained in vivo into the peritoneal cavity of mice did not trigger cell adhesion. In contrast, adherent cells were found in 4 and 24-hour-in vitro schistosomules. Our data on schistosomules obtained in vitro indicate that more than 24 hours are needed for complete remotion of molecules involved in the phenomenon of cell adhesion.

scholarly journals In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferases

2019 ◽  
Vol 229 ◽  
pp. 24-34
Author(s):  
Larissa Romanello ◽  
Ana Eliza Zeraik ◽  
Adriano de Freitas Fernandes ◽  
Juliana Roberta Torini ◽  
Louise E. Bird ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
In Vivo Characterization
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