Short-term Intensive Insulin Therapy Induces Long-term Good Control of Blood Glucose in Newly Diagnosed Type 2 Diabetes Mellitus

2021 ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Intensive Insulin Therapy ◽  
Good Control ◽  
Newly Diagnosed ◽  
Short Term

scholarly journals Improvement in insulin sensitivity following intensive insulin therapy and association of glucagon with long-term diabetes remission

2016 ◽  
Vol 44 (6) ◽  
pp. 1543-1550 ◽  
Author(s):  
Bo Zhang ◽  
Yan-yan Chen ◽  
Zhao-jun Yang ◽  
Xin Wang ◽  
Guang-wei Li
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Therapy ◽  
Intensive Insulin Therapy ◽  
Insulin Response ◽  
Newly Diagnosed ◽  
Intravenous Glucose

Objective To investigate the role of the acute glucagon response in the long-term remission of newly diagnosed type 2 diabetes mellitus following short-term intensive insulin therapy (IIT). Methods Ten patients with newly diagnosed type 2 diabetes mellitus received IIT. Intravenous glucose tolerance tests and the clamp technique were performed pre- and post-IIT. Remission was defined as maintenance of target glycaemic control without anti-diabetic agents for 1 year. Results The remission rate was 50% (5/10). There were no differences in the acute insulin response or glucose infusion rate between groups. The acute glucagon response (AGR) in the remission group pre-IIT was significantly higher than that in the non-remission group (mean 163.02 pg/mL/min vs. mean 16.29 pg/mL/min). The mean AGR post-IIT was lower in the remission group than that in the non-remission group (0 pg/mL/min vs. 19.91 pg/mL/min). Spearman analysis indicated that the AGR pre-IIT and the change in the AGR were correlated with remission (r = 0.731). Conclusion The insulin-mediated glucose disposal rate was significantly improved with the normalization of blood glucose levels following transient IIT. Subjects with a higher AGR pre-IIT and a greater AGR decrease post-IIT displayed a greater likelihood of long-term remission.

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