Efficacy of clear aligners in producing molar distalization: Systematic review

Objectives: The aim of this review is to systematically analyze the efficacy of molar distalization using clear aligners in non-growing Class II patients. Materials and Methods: A complete search across the electronic database through PubMed, Cochrane, Google scholar, LILACS, and manual search of orthodontic journals were done till 2019. Studies were selected on the basis of PRISMA guidelines. Results: A total of four articles were included in this review. The amount of molar distalization reported was 2–3 mm. Conclusion: Out of the four studies included. In all the studies a significant amount of distalization was reported. Three retrospective studies concluded that distalization with aligners is the most effective of all tooth movements. One study concluded that aligners effectively achieved distalization with an efficacy of 87%, other two studies concluded that aligners effectively distalized the molars with good control over vertical dimension and mesiodistal tipping.

Cellulose-Based Nanofibers Processing Techniques and Methods Based on Bottom-Up Approach—A Review

In the past decades, cellulose (one of the most important natural polymers), in the form of nanofibers, has received special attention. The nanofibrous morphology may provide exceptional properties to materials due to the high aspect ratio and dimensions in the nanometer range of the nanofibers. The first feature may lead to important consequences in mechanical behavior if there exists a particular orientation of fibers. On the other hand, nano-sizes provide a high surface-to-volume ratio, which can have important consequences on many properties, such as the wettability. There are two basic approaches for cellulose nanofibers preparation. The top-down approach implies the isolation/extraction of cellulose nanofibrils (CNFs) and nanocrystals (CNCs) from a variety of natural resources, whereby dimensions of isolates are limited by the source of cellulose and extraction procedures. The bottom-up approach can be considered in this context as the production of nanofibers using various spinning techniques, resulting in nonwoven mats or filaments. During the spinning, depending on the method and processing conditions, good control of the resulting nanofibers dimensions and, consequently, the properties of the produced materials, is possible. Pulp, cotton, and already isolated CNFs/CNCs may be used as precursors for spinning, alongside cellulose derivatives, namely esters and ethers. This review focuses on various spinning techniques to produce submicrometric fibers comprised of cellulose and cellulose derivatives. The spinning of cellulose requires the preparation of spinning solutions; therefore, an overview of various solvents is presented showing their influence on spinnability and resulting properties of nanofibers. In addition, it is shown how bottom-up spinning techniques can be used for recycling cellulose waste into new materials with added value. The application of produced cellulose fibers in various fields is also highlighted, ranging from drug delivery systems, high-strength nonwovens and filaments, filtration membranes, to biomedical scaffolds.

Remote-controlled cholangiography injection device: first clinical study in China

Background X-ray cholangiography is of great value in the imaging of biliary tract diseases; however, occupational radiation exposure is unavoidable. Moreover, clinicians must manually inject the contrast dye, which may result in a relatively high incidence of adverse reactions due to unstable injection pressure. Thus, there is a need to develop a novel remote-controlled cholangiography injection device. Methods Patients with external biliary drainage requiring cholangiography were included. A remote-controlled injection device was developed with three major components: an injection pump, a pressure sensor, and a wireless remote-control panel. Image quality, adverse reactions, and radiation dose were evaluated. Results Different kinds of X-ray cholangiography were successfully and smoothly performed using this remote-controlled injection device in all patients. The incidence of adverse reactions in the device group was significantly lower than that in the manual group (4.17% vs. 13.9%, P = 0.001), and increasing the injection pressure increased the incidence of adverse reactions. In addition, the device helped operators avoid ionizing radiation completely. Conclusions With good control of injection pressure (within 10 kPa), the remote-controlled cholangiography injection device could replace the need for the doctor to inject contrast agent with good security and effectivity. It is expected to be submitted for clinical application.

Induction Therapy Followed by Surgery for Unresectable Thymic Epithelial Tumours

Background and ObjectivesThe treatment of unresectable thymic epithelial tumours (TETs) remains controversial. Here, we present the efficacy and safety of induction therapy followed by surgery for unresectable TET.MethodsEighty-one patients with unresectable TETs treated with induction therapy followed by surgery were selected from a retrospective review of consecutive TETs from January 2005 to January 2021. Clinicopathological data were analyzed to assess tumour responses, resectability, adverse events, progression-free survival (PFS) and overall survival (OS).ResultsInduction therapy produced a major tumour response rate of 69.1%, a tumour response grade (TRG) 1-3 rate of 84.0% and an R0 resection rate of 74.1%. The most common toxic effects were all-grade neutropenia (35.8%) and anaemia (34.6%). The 10-year OS and PFS rates were 45.7% and 35.2%. Multivariate analysis showed that ypTNM stage, ypMasaoka stage, complete resection, and TRG were significant independent prognostic factors. Exploratory research revealed that different induction modalities and downstaging of T, N, M, TNM, or Masaoka classifications did not significantly alter the pooled hazard ratio for survival.ConclusionsInduction therapy followed by surgery is well tolerated in patients with unresectable TETs, with encouraging R0 resection rates. Multimodality management provides good control of tumors for unresectable TET patients.

Analysis and Evaluation of a Quasi-Passive Lower Limb Exoskeleton for Gait Rehabilitation

Using lower limb exoskeletons in healthcare sector like for rehabilitation is an important application. Lower limb exoskeletons can help in performing specific functions like gait assistance, and physical therapy support for patients who are lost their ability to walk again. Since active lower limb exoskeletons require more complicated control instrumentation and according to the limitations of the power/weight ratio that arises in such exoskeletons, many quasi-passive systems have developed and employed. This paper presents the design and testing of lightweight and adjustable two degree of freedom quasi-passive lower limb exoskeleton for improving gait rehabilitation. The exoskeleton consists of a high torque DC motor mounted on a metal plate above the hip joint, and a link that transmit assistance torque from the motor to the thigh. The knee joint is passively actuated with spring. The action of the passive component (spring) is combined with mechanical output of the motor to provide a good control on the designed exoskeleton during walking. The results show that muscles' efforts on both the front and the back sides of the user's leg were decreased when walking using the exoskeleton with the motor and spring.

Effects of Varying the Fin Width, Fin Height, Gate Dielectric Material, and Gate Length on the DC and RF Performance of a 14-nm SOI FinFET Structure

The FinFET architecture has attracted growing attention over the last two decades since its invention, owing to the good control of the gate electrode over the conductive channel leading to a high immunity from short-channel effects (SCEs). In order to contribute to the advancement of this rapidly expanding technology, a 3D 14-nm SOI n-FinFET is performed and calibrated to the experimental data from IBM by using Silvaco TCAD tools. The calibrated TCAD model is then investigated to analyze the impact of changing the fin width, fin height, gate dielectric material, and gate length on the DC and RF parameters. The achieved results allow gaining a better understanding and a deeper insight into the effects of varying the physical dimensions and materials on the device performance, thereby enabling the fabrication of a device tailored to the given constraints and requirements. After analyzing the optimal values from different changes, a new device configuration is proposed, which shows a good improvement in electrical characteristics.

IDENTIFICATION OF FORMALDEHYDE IN UNBRANDED WET NOODLES AT TRADITIONAL MARKETS OF TAMBUN SELATAN USING TEST KIT METHODS AND UV-VIS SPECTROPHOTOMETRY

Introduction: Wet noodles are flour-based foods that are widely consumed by the community because of their easy processing. The high water content in wet noodles makes the noodles not last long. In fact, there is still a preservative in wet noodles that is not used, namely formaldehyde. The purpose of this study was to determine whether there was formaldehyde in unbranded wet noodles in the Traditional Market of South Tambun District and to determine the level of formaldehyde in unbranded noodles in the Traditional Market of South Tambun District. Method: This research was conducted at the STIKes Mitra Keluarga laboratory. The type of research used is descriptive. There are 7 samples taken from 4 different markets. The sample was tested using a formaldehyde test kit and resulted in 6 positive formaldehyde samples. According to SNI, formaldehyde should not be in wet noodles. So that the results of the 6 samples did not meet the quality requirements of wet noodles. Results: Furthermore, the positive sample was determined using a UV-VIS spectrophotometer and Nash reagent. The lowest level of formaldehyde is 18.61 mg/L while the highest level is 738.45 mg/L. Conclusion: First, the regulation is not yet known by the producers because it is classified as traditional. Second, there is no good control from authorized institutions or officers. Third, the lack of guidance for producers

BHEP Class of Tests for Multivariate Normality: An Empirical Comparison

This paper compares the empirical power performances of eight tests for multivariate normality classified under Baringhaus-Henze-Epps-Pulley (BHEP) class of tests. The tests are compared under eight different alternative distributions. The result shows that the eight statistics have good control over type-I-error. Also, some tests are more sensitive to distributional differences with respect to their power performances than others. Also, some tests are generally more powerful than others. The generally most powerful ones are therefore recommended.

Numerical Simulation and Field Measurement Analysis of Fracture Evolution and Seepage Response of Key Aquiclude Strata in Backfill Mining

Solid waste backfill mining can effectively deal with gangue and other mining wastes, as well as control the movement and damage of rock strata. In this paper, the RFPA2D rock failure process analysis software is used to study the fracture evolution and seepage response mechanism of the key aquiclude strata (KAS) under the conditions of different structural characteristics, interlayer rock thickness, and backfilling ratios in backfill mining. The simulation results show that, in backfill mining, soft rock plays a crucial role in the fracture repair of KAS with different structural characteristics. An increase in the KAS thickness from 15 to 35 m is shown to results in a continuously improved repair of KAS fractures. At the advancing distance of the working face of 50~100 m and the KAS thickness of 35 m, the minimum vertical seepage velocity of 0.06 ‐ 0.78 × 10 − 2 m / s is reached. An increase in the backfilling ratio from 45 to 80% improves the control effect on the overlying strata. A case study of backfill mining in the Wugou Coal Mine located in the Anhui Province of China was conducted. At the goaf backfilling ratio of 80%, the composite KAS’s good control effect was achieved, which minimized seepage and avoided the water in rush phenomena. The above engineering application ensured the safe backfill mining of coal resources.

Opportunities and Obstacles Associated With Sequential Immune Reconstitution Therapy for Multiple Sclerosis: A Case Report

Cladribine is an effective disease-modifying treatment for relapsing-remitting multiple sclerosis that acts as an immune reconstitution therapy and is administered in a pulsed manner. Despite its efficacy, severe disease reactivation early after treatment represents a serious clinical problem, and clear evidence to guide the management of such a situation is lacking. Here, we describe the case of a patient experiencing considerable disease activity during the 1st year after the initiation of cladribine treatment. The patient was switched to alemtuzumab and, therefore, received double immune reconstitution therapy. Data regarding this approach are lacking, and real-world observations may be of interest. Despite achieving good control of disease activity, we observed several serious infectious complications. Our results suggest that sequential immune reconstitution therapies may be effective; however, at the price of higher susceptibility to infections.