Effectiveness of Serum Periostin and IL-13 Levels in Determining Blood Eosinophilia in Severe Asthma

Tropical pulmonary eosinophilia (TPE) is characterized by lung tissue and peripheral blood eosinophilia. Serum total IgE is also markedly increased in TPE. However, an association with asthma or other hypersensitivity conditions has not been described. During the diagnostic workup of three patients eventually confirmed to have TPE, hypersensitivity to the fungus, Aspergillus Fumigatus was found. However, there was no evidence of diseases of aspergillus hypersensitivity such as severe asthma with fungal sensitization (SAFS) and allergic bronchopulmonary aspergillosis (ABPA). This association however raises the possibility of a future risk of these potentially serious allergic respiratory manifestations.RiassuntoL’eosinofilia polmonare tropicale (TPE) è caratterizzata da tessuto polmonare e eosinofilia nel sangue periferico. Anche il siero IgE totale è notevolmente aumentato in TPE. Tuttavia, un’associazione con asma o altre condizioni di ipersensibilità non è stata descritta. Durante l'iter diagnostico di tre pazienti, che alla fine si sono rivelati presentare TPE, ipersensibilità al fungo, è stato trovato l’Aspergillus fumigatus. Tuttavia, non vi era alcuna evidenza di malattie di Aspergillus ipersensibilità come l'asma grave con sensibilizzazione fungina (SAF) e aspergillosi broncopolmonare allergica (ABPA). Questa associazione pone tuttavia la possibilità di un rischio futuro di queste potenzialmente gravi manifestazioni allergiche respiratorie.

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Effect of tralokinumab on serum periostin and IgE levels in uncontrolled severe asthma

10.1183/13993003.congress-2015.oa1770 ◽

2015 ◽

Cited By ~ 1

Author(s):

Koustubh Ranade ◽

Scott Manetz ◽

Meina Liang ◽

Rozanne (Yen-Wah) Lee ◽

Michael Kuziora ◽

...

Keyword(s):

Severe Asthma ◽

Serum Periostin

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Serum Interleukin (IL)-6 levels in patients with severe asthma disease is associated with blood eosinophilia

10.1183/13993003.congress-2020.209 ◽

2020 ◽

Author(s):

Abhinav Singla ◽

Franziska Engbert ◽

Hümeyra Kas ◽

Faustine Funke ◽

Ina Haasler ◽

...

Keyword(s):

Severe Asthma ◽

Blood Eosinophilia

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Serum periostin is associated with type 2 immunity in severe asthma

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2015.12.1346 ◽

2016 ◽

Vol 137 (6) ◽

pp. 1904-1907.e2 ◽

Cited By ~ 25

Author(s):

Mats W. Johansson ◽

Michael D. Evans ◽

Gina M. Crisafi ◽

Cécile T.J. Holweg ◽

John G. Matthews ◽

...

Keyword(s):

Severe Asthma ◽

Type 2 Immunity ◽

Serum Periostin

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“T2-high” in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin

European Respiratory Journal ◽

10.1183/13993003.00938-2018 ◽

2018 ◽

Vol 53 (1) ◽

pp. 1800938 ◽

Cited By ~ 34

Author(s):

Stelios Pavlidis ◽

Kentaro Takahashi ◽

Francois Ng Kee Kwong ◽

Jiaxing Xie ◽

Uruj Hoda ◽

...

Keyword(s):

Gene Expression ◽

Nitric Oxide ◽

Severe Asthma ◽

Exhaled Nitric Oxide ◽

Blood Eosinophil ◽

Moderate Asthma ◽

Serum Ige ◽

Clinical Biomarkers ◽

High Signature ◽

Serum Periostin

Type-2 (T2) immune responses in airway epithelial cells (AECs) classifies mild–moderate asthma into a T2-high phenotype. We examined whether currently available clinical biomarkers can predict AEC-defined T2-high phenotype within the U-BIOPRED cohort.The transcriptomic profile of AECs obtained from brushings of 103 patients with asthma and 44 healthy controls was obtained and gene set variation analysis used to determine the relative expression score of T2 asthma using a signature from interleukin (IL)-13-exposed AECs.37% of asthmatics (45% nonsmoking severe asthma, n=49; 33% of smoking or ex-smoking severe asthma, n=18; and 28% mild–moderate asthma, n=36) were T2-high using AEC gene expression. They were more symptomatic with higher exhaled nitric oxide fraction (FeNO) and blood and sputum eosinophils, but not serum IgE or periostin. Sputum eosinophilia correlated best with the T2-high signature. FeNO (≥30 ppb) and blood eosinophils (≥300 cells·µL−1) gave a moderate prediction of T2-high asthma. Sputum IL-4, IL-5 and IL-13 protein levels did not correlate with gene expression.T2-high severe asthma can be predicted to some extent from raised levels of FeNO, blood and sputum eosinophil counts, but serum IgE or serum periostin were poor predictors. Better bedside biomarkers are needed to detect T2-high.

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Serum periostin levels are associated with asthma severity in children

10.22541/au.160743206.64480753/v1 ◽

2020 ◽

Author(s):

S. Tolga Yavuz ◽

Soyhan Bagci ◽

Ahmet Bolat ◽

onur akın ◽

Rainer Ganschow

Keyword(s):

Severe Asthma ◽

Allergic Diseases ◽

Asthma Severity ◽

Multivariable Logistic Regression Analysis ◽

Pediatric Allergy ◽

Control Subjects ◽

Children With Asthma ◽

Gina Guidelines ◽

And Control ◽

Serum Periostin

Background: Periostin has emerged as a novel biomarker in the pathogenesis of T helper 2-type allergic diseases in the last years. The aim of this study was to investigate the association of serum periostin levels with clinical features in children with asthma. Methods: Children with physician-diagnosed asthma who attended regularly to an outpatient pediatric allergy and asthma center were enrolled in the study along with control subjects. Asthma severity and control status of the patients were evaluated according to recent GINA guidelines. Results: A total of 158 children (125 with asthma and 33 age and sex-matched control subjects) with a median age of 10.2 years (range 5.9-17.0) were enrolled. Asthma severity was mild in 41 (32.8%), moderate in 63 (50.4%) and severe in 21 (16.8%) children. Children with asthma had significantly higher periostin levels than controls (53.1 ± 13.1 vs 43.0 ± 11.2 ng/mL; p < 0.001). The mean serum periostin levels of children with severe asthma (63.8 ± 10.8) were significantly higher than in children with moderate asthma (53.3 ± 12.7) and mild asthma (47.4 ± 11.1) (p < 0.001). Serum periostin levels were found to be significantly correlated with asthma severity (Spearman’s rho [r]=0.41, p < 0.001). Results of multivariable logistic regression analysis demonstrated an association between serum periostin levels and asthma severity in children (OR, 1.10; 95% CI, 1.04-1.15; p <0.001) Conclusion: Serum periostin levels may serve clinicians in identifying children with severe asthma.

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