scholarly journals Expression of Xeroderma Pigmentosum Group G (XPG) in Sporadic Breast Carcinoma

2010 ◽  
Vol 18 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Yoshihisa Koyama ◽  
Masashi Higashimoto ◽  
Kenji Gonda ◽  
Jun Ito ◽  
Nobuhiro Yoshimoto ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Xeroderma Pigmentosum ◽  
Sporadic Breast Carcinoma ◽  
Xeroderma Pigmentosum Group G

Purkinje cell degeneration in mice lacking the xeroderma pigmentosum group G gene

2001 ◽  
Vol 64 (4) ◽  
pp. 348-354 ◽  
Author(s):  
Xue-Zhi Sun ◽  
Yoshi-Nobu Harada ◽  
Sentaro Takahashi ◽  
Naoko Shiomi ◽  
Tadahiro Shiomi
Keyword(s):  
Purkinje Cell ◽  
Xeroderma Pigmentosum ◽  
Cell Degeneration ◽  
Purkinje Cell Degeneration ◽  
Xeroderma Pigmentosum Group G

scholarly journals Postnatal Growth Failure, Short Life Span, and Early Onset of Cellular Senescence and Subsequent Immortalization in Mice Lacking the Xeroderma Pigmentosum Group G Gene

1999 ◽  
Vol 19 (3) ◽  
pp. 2366-2372 ◽  
Author(s):  
Yoshi-Nobu Harada ◽  
Naoko Shiomi ◽  
Manabu Koike ◽  
Masahito Ikawa ◽  
Masaru Okabe ◽  
...  
Keyword(s):  
Early Onset ◽  
Xeroderma Pigmentosum ◽  
Excision Repair ◽  
Growth Failure ◽  
Postnatal Growth ◽  
Additional Function ◽  
Xeroderma Pigmentosum Group G ◽  
Postnatal Growth Failure ◽  
Deficient Mice

ABSTRACT The xeroderma pigmentosum group G (XP-G) gene (XPG) encodes a structure-specific DNA endonuclease that functions in nucleotide excision repair (NER). XP-G patients show various symptoms, ranging from mild cutaneous abnormalities to severe dermatological impairments. In some cases, patients exhibit growth failure and life-shortening and neurological dysfunctions, which are characteristics of Cockayne syndrome (CS). The known XPG protein function as the 3′ nuclease in NER, however, cannot explain the development of CS in certain XP-G patients. To gain an insight into the functions of the XPG protein, we have generated and examined mice lacking xpg (the mouse counterpart of the humanXPG gene) alleles. The xpg-deficient mice exhibited postnatal growth failure and underwent premature death. SinceXPA-deficient mice, which are totally defective in NER, do not show such symptoms, our data indicate that XPG performs an additional function(s) besides its role in NER. Our in vitro studies showed that primary embryonic fibroblasts isolated from thexpg-deficient mice underwent premature senescence and exhibited the early onset of immortalization and accumulation of p53.

Study of Her-2/neu and TOP2A expression in familial versus sporadic breast carcinoma

2013 ◽  
Vol 12 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Asaad M.S. El-Gerzawy ◽  
Mervat M.S. Al Ansary ◽  
Iman L. Hussein ◽  
Amal M. Mohamed ◽  
Fatma M. Abou El-Kasem ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Sporadic Breast Carcinoma ◽  
Her 2

scholarly journals Polymorphism of Xeroderma Pigmentosum group G and the risk of lung cancer and squamous cell carcinomas of the oropharynx, larynx and esophagus

2005 ◽  
Vol 118 (3) ◽  
pp. 714-720 ◽  
Author(s):  
Yan Cui ◽  
Hal Morgenstern ◽  
Sander Greenland ◽  
Donald P. Tashkin ◽  
Jenny Mao ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell ◽  
Xeroderma Pigmentosum ◽  
Squamous Cell Carcinomas ◽  
Xeroderma Pigmentosum Group G

scholarly journals A genetic mouse model carrying the nonfunctional xeroderma pigmentosum group G gene

2003 ◽  
Vol 43 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Xue-Zhi Sun ◽  
Yoshi-Nobu Harada ◽  
Rui Zhang ◽  
Chun Cui ◽  
Sentaro Takahashi ◽  
...  
Keyword(s):  
Mouse Model ◽  
Xeroderma Pigmentosum ◽  
Genetic Mouse Model ◽  
Xeroderma Pigmentosum Group G
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