scholarly journals Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial

2016 ◽  
Vol 17 (1) ◽  
pp. 3-6 ◽  
Author(s):  
Mahmoud Abu-Ta'a
Keyword(s):  
Clinical Trial ◽  
Tissue Regeneration ◽  
Bone Allograft ◽  
Guided Tissue Regeneration ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Freeze Dried ◽  
Attachment Level ◽  
Preservation Technique ◽  
Postoperative Discomfort

ABSTRACT Aim This randomized clinical trial compares the usefulness of adjunctive antibiotics, while strict asepsis was followed during periodontal surgery involving guided tissue regeneration. Materials and methods Two groups of 20 consecutive patients each with advanced periodontal disease were randomly assigned to treatment. They displayed one angular defect each with an intrabony component ≥3 mm, probing pocket depth and probing attachment level (PAL) ≥7 mm. Test group included 13 males, mean age 60 years, treated with enamel matrix derivative (EMD) and demineralized freeze-dried bone allograft with modified papilla preservation technique, received oral amoxicillin 1 gm, 1 hour preoperatively and 2 gm for 2 days postoperatively. Control group included 10 males, mean age 57 years, treated with EMD and demineralized freeze-dried bone allograft with modified papilla preservation technique, received no antibiotics. Outcome measures were clinical attachment level (CAL) gain, residual periodontal pocket depth (res. PD), gingival recession (GR), bleeding on probing (BOP), adverse events and postoperative complications. Patients were followed up to 12 months after periodontal surgery involving guided tissue regeneration. Results There were no significant differences between both groups for CAL gain, res. PD, GR, BOP nor other clinical parameters, though patients’ subjective perception of postoperative discomfort was significantly smaller in the group receiving antibiotics. Conclusion Antibiotics do not provide significant advantages concerning clinical periodontal parameters nor concerning postoperative infections in case of proper asepsis. It does, on the contrary, reduce postoperative discomfort. Clinical significance Regarding the results of this study, adjunctive systemic antibiotics in combination with guided tissue regeneration may be useful in reducing postoperative discomfort but may not be helpful for improving periodontal regeneration outcomes. How to cite this article Abu-Ta'a M. Adjunctive Systemic Antimicrobial Therapy vs Asepsis in Conjunction with Guided Tissue Regeneration: A Randomized, Controlled Clinical Trial. J Contemp Dent Pract 2016;17(1):3-6.

scholarly journals Clinical Management of Endo-Perio Lesion Through Guided Tissue Regeneration: a 5 Year Follow-Up

2021 ◽  
pp. 151-156
Author(s):  
Munis Mukhtar ◽  
Maaz Asad ◽  
Asaad Javaid Mirza
Keyword(s):  
Tissue Regeneration ◽  
Bone Allograft ◽  
Clinical Findings ◽  
Guided Tissue Regeneration ◽  
Collagen Membrane ◽  
Pocket Depth ◽  
Radiographic Findings ◽  
Freeze Dried ◽  
Distal Surface

Progressive periodontal disease causes loss of supporting structures of teeth resulting in deep bony defects. In this case a report of 22-year old female patient is being presented with clinical findings of vertical bone loss in two adjacent teeth, on distal surface of  2nd  upper right premolar and mesial surface of upper right 1st molar. Root canal treatment, non-surgical periodontal therapy followed by guided tissue regeneration was carried out using decalcified freeze-dried bone allograft (DFDBA) and collagen membrane. Analysis of clinical and radiographic findings showed marked reduction in pocket depth up to 12mm with hard tissue repair on 3-month, 2-year and 5- year follow ups.

scholarly journals Treatment of a Developmental Groove and Supernumerary Root Using Guided Tissue Regeneration Technique

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Zahra Alizadeh Tabari ◽  
Hamed Homayouni ◽  
Tahere Pourseyediyan ◽  
Armita Arvin ◽  
Derrick Eiland ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Root Canal ◽  
Combined Treatment ◽  
Bone Allograft ◽  
Guided Tissue Regeneration ◽  
Maxillary Incisor ◽  
Treatment Procedure ◽  
Root Canal Therapy ◽  
Probing Depth ◽  
Freeze Dried

Introduction. The radicular groove is a developmental groove which is usually found on the palatal or lateral aspects of the maxillary incisor teeth. The present case is a maxillary lateral incisor with a small second root and a deep radicular groove. The developmental groove caused a combined periodontal-endodontic lesion. Methods. Case was managed using a combined treatment procedure involving nonsurgical root canal therapy and surgical periodontal treatment. After completion of root canal treatment, guided tissue regeneration (GTR) was carried out using decalcified freeze dried bone allograft (DFDBA) and a bioabsorbable collagenous membrane. Tooth also was splinted for two months. Results. After 12 months the tooth was asymptomatic. The periapical radiolucency disappeared and probing depth did not exceed 3 mm. Conclusion. Combined treatment procedure involving nonsurgical root canal therapy and surgical periodontal regenerative treatment can be a predictable technique in treating combined endodontic-periodontal lesions caused by radicular groove.

scholarly journals Evaluation of the clinical efficacy of 1.2% atorvastatin by CBCT in the treatment of periodontal intrabony defects: A randomized controlled clinical trial

2019 ◽  
Vol 13 (3) ◽  
pp. 183-191
Author(s):  
Prerna Y. Shirke ◽  
Abhay P. Kolte ◽  
Rajashri A. Kolte ◽  
Pranjali V. Bawanakar
Keyword(s):  
Clinical Trial ◽  
Statistical Significance ◽  
Periodontal Regeneration ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Treat Ment ◽  
Group 2 ◽  
Attachment Level ◽  
Group 1

Background. Atorvastatin (ATV), which belongs to the statin class of drugs, is the formidable inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. This clinical trial evaluated and compared the clinical and radiographic changes in chronic periodontitis (CP) patients, obtained through 1.2% ATV as an adjunct to scaling and root planing (SRP) in the treat-ment of intraosseous defects. Methods. Twenty CP patients, with a minimum of one pair of bilateral intraosseous, were randomly selected for this split-mouth study. Group 1 included 20 sites treated with SRP and subgingival delivery of a placebo gel, whereas an equal number of sites in group 2 were treated by SRP along with subgingival delivery of 1.2% ATV gel. The plaque index (PI), modified sulcus bleeding index (mSBI), probing pocket depth (PPD) and clinical attachment level (CAL) were evaluated at baseline and 3- and 6-month intervals, while the intraosseous defect was assessed at baseline and 6-month interval using cone-beam computed tomography (CBCT). Paired t-test was used to determine statistical significance. Results. A greater reduction in the mean PPD and gain in CAL was found in group 2 compared to group 1 at 3- and 6-month intervals. Furthermore, a significantly greater bone fill was obtained in group 2 (1.70±0.54 mm) compared to group 1 (0.22±0.43 mm) after six months.Conclusion. ATV, as an adjunct to SRP, enhanced periodontal regeneration, as a noninvasive way to treat periodontal in-traosseous defects.

scholarly journals Probing Pocket Depth and Clinical Attachment Level between Non-Surgical and Surgical Periodontal Therapy in Chronic Periodontitis Patients: A Randomised Controlled Clinical Trial

2018 ◽  
Vol 2 (2) ◽  
pp. 40-44
Author(s):  
Harish Kumar Shah ◽  
Shivalal Sharma ◽  
Khushboo Goel ◽  
Sajeev Shrestha ◽  
Surya Raj Niraula
Keyword(s):  
Clinical Trial ◽  
Surgical Therapy ◽  
Chronic Periodontitis ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Probing Pocket Depth ◽  
The Mean ◽  
The Difference ◽  
Attachment Level

Background: : Chronic periodontitis is one of the most common form of periodontal diseases which either require non-surgical periodontal therapy or open flap debridement-surgical therapy or both. To date, it is unclear as of how much changes occur after NSPT or OFD and which therapy provides the best outcome in chronic periodontitis having probing pocket depth ≥ 5-7 mm. Aim: The aim of this randomized controlled clinical trial was to evaluate the Probing Pocket Depth and Clinical Attachment Level between NSPT and OFD in chronic periodontitis patients. Materials and Methods: A total of 52 healthy patients with PPD ≥ 5-7 mm were included in the present study. Half of the patients assigned for the NSPT and half in the OFD group. The PPD and CAL were measured at baseline, three and six months. Independent sample t-test was used to compare the change in mean PPD and CAL between NSPT and OFD group at three and six months, respectively. Results: The difference in the mean decrease of PPD between NSPT and OFD group at three and six months were 0.15 mm (P<0.05) and 0.19 mm (P<0.05), respectively. The difference in the mean gain of CAL between NSPT and OFD group at three and six months were 0.03 mm (p>0.05) and 0.12 mm (P<0.05), respectively. Conclusion: Substantial improvement in periodontal status occurred with both the therapies, however, significantly higher decrease in PPD and gain in CAL were seen with surgical therapy.

Treatment of Endodontic Perforations Using Guided Tissue Regeneration and Freeze-Dried Bone Allograft: Two Case Reports with 2-4 Year Post-Surgical Evaluations

2004 ◽  
Vol 5 (3) ◽  
pp. 131-141 ◽  
Author(s):  
Elton Golçalves Zenobio ◽  
Jamil Awad Shibli
Keyword(s):  
Tissue Regeneration ◽  
Case Reports ◽  
Correct Diagnosis ◽  
Combined Treatment ◽  
Bone Allograft ◽  
Guided Tissue Regeneration ◽  
Radiographic Evidence ◽  
Freeze Dried ◽  
Bone Gain

Abstract Clinicians often have difficulty with the diagnosis and treatment of root perforation. This paper reports two patients with root perforation treated with periodontal surgery associated with guided tissue regeneration (GTR) and demineralized freeze-dried bone allograft (DFDBA). This combined treatment resulted in minimal probing depths, minimal attachment loss, and radiographic evidence of bone gain after follow-up evaluations that ranged from 2 to 4 years. These case reports show a correct diagnosis and removal of etiologic factors can restore both periodontal and endodontic health. Citation Zenobio EG, Shibli JA. Treatment of Endodontic Perforations Using Guided Tissue Regeneration and Freeze-Dried Bone Allograft: Two Case Reports with 2-4 Year Post-Surgical Evaluations. J Contemp Dent Pract 2004 August;(5)3:131-141.

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