Metastatic Adenoid Cystic Carcinoma of Prostate: Is Androgen Deprivation Therapy Beneficial?

ABSTRACT Adenoid cystic carcinoma of prostate is a rare malignancy arising from basal cells of prostatic acini. The management of metastatic adenoid cystic carcinoma of prostate is not well defined because of its rarity. We report a 68-year-old male presented with acute urinary retention and pain in left hip region. Digital rectal examination revealed a hard nodular prostate with extension to the lateral pelvic walls. His serum PSA was 0.15 ng/ml. Transrectal ultrasound (TRUS) guided prostate biopsy revealed adenoid cystic carcinoma. Bone scan showed metastasis in left acetabulum. He underwent channel transurethral resection of prostate and bilateral orchiectomy. He received palliative radiotherapy for left acetabular metastasis to control his pain. At 3 years of follow-up, the patient is doing well with no new metastasis. Hormone therapy is a viable option in patients with metastatic adenoid cystic carcinoma of prostate. How to cite this article Singh SK, Gnanasekharan M, Kumar S, Ganesamoni R, Bal A. Metastatic Adenoid Cystic Carcinoma of Prostate: Is Androgen Deprivation Therapy Beneficial. J Postgrad Med Edu Res 2014;48(1):43-45.

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Two Different Cell Populations Is an Important Clue for Diagnosis of Primary Cutaneous Adenoid Cystic Carcinoma: Immunohistochemical Study

Case Reports in Pathology ◽

10.1155/2017/7949361 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Banu Ince Alkan ◽

Onder Bozdogan ◽

Müjde Karadeniz ◽

Nazan Bozdoğan

Keyword(s):

Differential Diagnosis ◽

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Adenoid Cystic Carcinoma ◽

Immunohistochemical Study ◽

Cell Populations ◽

Metastatic Lesions ◽

Adenoid Cystic ◽

Rare Malignancy ◽

Immunohistochemical Studies

Primary cutaneous adenoid cystic carcinoma (PCACC) is a very rare malignancy. The differential diagnosis of PCACCs in pathology practice can be difficult and a group of primary and metastatic lesions, including adenoid basal cell carcinoma of the skin, should be considered in the differential diagnosis. Besides histomorphological clues, immunohistochemistry studies are very helpful in the differential diagnosis of PCACC. We report herein a case of PCACC with extensive immunohistochemical studies and review the literature from an immunohistochemistry perspective.

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In vitro and in vivo evaluation of cytotoxic effect of targeted agents alone or in combination with chemotherapy for the treatment of adenoid cystic carcinoma

10.21203/rs.3.rs-446009/v1 ◽

2021 ◽

Author(s):

Teresa Savarese ◽

Andrea Abate ◽

Ram Manohar Basnet ◽

Luigi Lorini ◽

Cristina Gurizzan ◽

...

Keyword(s):

Targeted Therapy ◽

Adenoid Cystic Carcinoma ◽

Standard Chemotherapy ◽

In Vivo Evaluation ◽

Cytotoxic Effects ◽

Chemotherapy Drugs ◽

Adenoid Cystic ◽

Rare Malignancy

Abstract Purpose Adenoid cystic carcinoma (ACC) is a rare malignancy characterized by high incidence of relapse. When relapsing, ACC has an indolent but relentless behaviour, thus leading to a poor long-term prognosis. The treatment of choice of relapsing ACC remains surgery followed by radiotherapy, whenever feasible. Therapeutic weapons are limited to systemic drugs. The most widely used chemotherapy regimen is the combination of cisplatin and doxorubicin, however with low response rate and not long lasting; there is also a lack of alternatives for second line therapies in case of disease progression. Therefore, a more comprehensive strategy aimed at identifying at preclinical level the most promising drugs or combination is clearly needed. Methods In this study, the cytotoxic effects of two standard chemotherapy drugs, cisplatin and doxorubicin, and of five targeted therapy-drugs was tested in vitro, on an h-TERT immortalized ACC cell line. The same drugs were also tested in vivo, on zebrafish embryos with ACC tumoral cell xenograft. Then, combinations of one standard chemotherapy drug plus one targeted therapy drug were also evaluated, in order to find the best treatment strategy for ACC. Results Data obtained demonstrated that both vorinostat and olaparib significantly increased the standard chemotherapy cytotoxic effects, suggesting new interesting therapeutic options for ACC. Conclusion Data obtained in the present study provide valid new therapeutic strategies for ACC to be translated in a prospective clinical trial.

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Gynecomastia or rare malignancy? A young man with an unremarkable history proves to have adenoid cystic carcinoma of the breast

The Breast Journal ◽

10.1111/tbj.13534 ◽

2020 ◽

Vol 26 (3) ◽

pp. 502-504

Author(s):

Jack Mackenzie ◽

Charles Douglas

Keyword(s):

Adenoid Cystic Carcinoma ◽

Carcinoma Of The Breast ◽

Adenoid Cystic ◽

Rare Malignancy

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Endoscopic resection of sinonasal adenoid cystic carcinoma with radiofrequency coblation. A clinical report with literature review

Polski Przegląd Otorynolaryngologiczny ◽

10.5604/01.3001.0013.8789 ◽

2020 ◽

Vol 9 (1) ◽

pp. 44-49

Author(s):

Pedro Clarós ◽

Agnieszka Waląg ◽

Pedro Claros

Keyword(s):

Adenoid Cystic Carcinoma ◽

Slow Growth ◽

Inferior Turbinate ◽

Clinical Report ◽

Open Approach ◽

Sinonasal Cancer ◽

Adenoid Cystic ◽

The Subject ◽

Rare Malignancy ◽

Delay Of Diagnosis

Introduction Sinonasal cancer is very rare and accounts for under 1% of all malignancies of which sinonasal adenoid cystic carcinoma (SNACC) is about 5%. The maxillary sinus is the most common site of SNACC. Misleading symptomatology which overlaps with rhinosinusitis contributes to the delay of diagnosis. Recently, the endoscopic approach is commonly applied with equal or better results to the open approach. Radiofrequency coblation might be used to reduce blood loss. Material and Methods We present a case of an adenoid cystic carcinoma arising from the left inferior turbinate. The patient received endoscopic surgical treatment with the application of radiofrequency coblation in Clarós Clinic at the beginning of 2019 and remains followed up with no sign of recurrence. Afterward, we review the literature on the subject. Conclusion SnACC is a rare malignancy, characterized by slow growth and perineural infiltration with spreading towards the skull base, cavernous sinus, and orbit. The regional nodal involvement is rare. Frequent and delayed distant metastasis in lung, bone, liver, and brain are also typical. Prognosis is poor with the 5-year overall survival between 41%-86%. Surgery with or without complementary radiotherapy provides the best outcomes for the majority of patients. The significance of prognostic factors remains unclear. Lifelong surveillance is obligatory as very late recurrences are common.

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Adenoid cystic carcinoma - A rare malignancy in the Submandibular salivary gland.

Narayana Medical Journal ◽

10.5455/nmj./00000165 ◽

2019 ◽

pp. 1

Author(s):

Bhavana Grandhi ◽

Mohan Nandam ◽

Vijayalakshmi Murramreddy ◽

Ramesh Gagguturi

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Submandibular Salivary Gland ◽

Adenoid Cystic ◽

Rare Malignancy

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Continual Cough: Experience and Lessons from a Case of Bronchial Adenoid Cystic Carcinoma

Current Bioinformatics ◽

10.2174/1574893615666200831170923 ◽

2020 ◽

Vol 15 ◽

Author(s):

Lin Sheng ◽

Junwei Tu ◽

Yijun Sheng ◽

Jingqian Zhu ◽

Huijun Chen ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Palliative Radiotherapy ◽

Final Diagnosis ◽

Case Presentation ◽

Delayed Treatment ◽

Adenoid Cystic ◽

Long Time ◽

Missed Diagnosis ◽

Low Incidence ◽

Slow Growing

Background: Primary tracheal adenoid cystic carcinoma is a rare, slow-growing pulmonary malignancy. Due to the low incidence, clinicians are poor in the diagnosis and treatment of such disease, which is prone to cause misdiagnosis or missed diagnosis, consequently leading to delayed treatment. Case Presentation: Here, we reported a case of a 72-year-old woman who was diagnosed as primary bronchial adenoid cystic carcinoma after three years. At the time of final diagnosis, lesion involvement was seen in the entire bronchus and radical treatment was not available. Conclusions: Endoscopic bronchoscopy and palliative radiotherapy can relieve the symptoms of the patient and make the patient survive with the tumor for a long time.

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Adenoid cystic carcinoma of the breast with distant metastasis to the liver and spleen: a case report

Journal of Surgical Case Reports ◽

10.1093/jscr/rjaa483 ◽

2020 ◽

Vol 2020 (11) ◽

Author(s):

Breanne Gillie ◽

Michael Kmeid ◽

Armand Asarian ◽

Philip Xiao

Keyword(s):

Adenoid Cystic Carcinoma ◽

Triple Negative ◽

Treatment Guideline ◽

Excisional Biopsy ◽

Breast Cancers ◽

Palpable Mass ◽

Adenoid Cystic ◽

Screening Mammograms ◽

Low Incidence ◽

Rare Malignancy

Abstract Adenoid cystic carcinoma (ACC) of the breast is a rare malignancy, accounting for 0.1–1% of breast cancers. Histologically breast ACC is similar to ACC’s found in salivary tissue and is a triple-negative breast cancer with an uncharacteristically favorable prognosis and low incidence of metastasis. Most cases present as a painful, palpable mass; however, asymptomatic cases found on screening mammograms have also been noted. Core needle biopsy or excisional biopsy is necessary for definitive diagnosis of breast ACC. Immunohistochemistry of these cancers can differentiate breast ACC from masses with similar histology, such as invasive cribriform carcinoma and collagenous spherulosis. There is no well-established treatment guideline for ACC; however, it has been noted that reoccurrence and metastasis are noted more in cases of local resection than mastectomy.

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