Lanthanum chloride was found to be an effective catalyst for the facile and one-pot synthesis of polysubstituted imidazoles under solvent free condition in excellent yields. This method elucidates urea/thiourea, as an environmentally benign source of ammonia for the synthesis of polysubstituted imidazoles. The work-up procedure is very simple and the products don’t require further purification.
Microwave-Assisted One-Pot Synthesis of Octahydroquinazolinone Derivatives Catalyzed by Thiamine Hydrochloride Under Solvent-free Condition
