scholarly journals Epicardial Adipose Tissue and Atrial Fibrillation

2021 ◽  
Vol 41 (4) ◽  
pp. 165-172
Author(s):  
Shintaro Kira ◽  
Ichitaro Abe ◽  
Naohiko Takahashi
Keyword(s):  
Atrial Fibrillation ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue

Updates on epicardial adipose tissue mechanisms on atrial fibrillation

2021 ◽  
Author(s):  
Marinela Couselo‐Seijas ◽  
Moisés Rodríguez‐Mañero ◽  
José R. González‐Juanatey ◽  
Sonia Eiras
Keyword(s):  
Atrial Fibrillation ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue

Epicardial Adipose Tissue and Postoperative Atrial Fibrillation

2021 ◽  
Author(s):  
Petraglia Laura ◽  
Conte Maddalena ◽  
Comentale Giuseppe ◽  
Cabaro Serena ◽  
Campana Pasquale ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Adipose Tissue ◽  
Cardiac Surgery ◽  
Epicardial Adipose Tissue ◽  
Perioperative Period ◽  
Postoperative Atrial Fibrillation ◽  
Serum Samples ◽  
Monocyte Chemoattractant Protein 1 ◽  
Elective Cardiac Surgery ◽  
Increased Risk

Abstract Background. Atrial fibrillation (AF) often occurs after cardiac surgery and is associated to increased risk of stroke and mortality. Several evidence support the important role of inflammation in the pathogenesis of postoperative atrial fibrillation (POAF). It is known that an increased volume and a pro-inflammatory phenotype of epicardial adipose tissue (EAT) are both associated with AF onset in non surgical context. In the present study, we aim to evaluate whether also POAF occurrence may be triggered by an exalted production of inflammatory mediators from EAT.Methods. The study population was composed of 105 patients, with no history of paroxysmal or permanent AF, undergoing elective cardiac surgery. After clinical evaluation, all patients performed an echocardiographic study including the measurement of EAT thickness. Serum samples and EAT biopsies were collected before surgery. Levels of 10 inflammatory cytokines were measured in serum and EAT conditioned media. After surgery, cardiac rhythm was monitored for 7 days.Results. Forty-four patients (41.3%) developed POAF. As regard to cardiovascular therapy, only statin use was significantly lower in POAF patients (65.1% vs. 84.7%; p-0.032). Levels of Monocyte Chemoattractant Protein-1 (MCP-1), in both serum and EAT, were significantly higher in POAF patients (130.1 pg/ml vs. 68.7 pg/ml; p = < 0.001; 322.4 pg/ml vs. 153.4 pg/ml; p = 0.028 respectively). EAT levels of IL-6 were significantly increased in POAF patients compared to those in sinus rhythm (126.3 pg/ml vs. 23 pg/ml; p = < 0.005).ConclusionHigher EAT levels of IL6 and MCP1 are significantly associated with the occurrence of POAF. Statin therapy seems to play a role in preventing POAF. These results might pave the way for a targeted use of these drugs in the perioperative period.

scholarly journals Does Epicardial Adipose Tissue Influence Postoperative Atrial Fibrillation?

2019 ◽  
Vol 25 (3) ◽  
pp. 149-157 ◽  
Author(s):  
Hiroko Kogo ◽  
Akira Sezai ◽  
Shunji Osaka ◽  
Motomi Shiono ◽  
Masashi Tanaka
Keyword(s):  
Atrial Fibrillation ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Postoperative Atrial Fibrillation

Cholinergic activity regulates the secretome of epicardial adipose tissue: Association with atrial fibrillation

2018 ◽  
Vol 234 (7) ◽  
pp. 10512-10522 ◽  
Author(s):  
Marinela Couselo‐Seijas ◽  
Jose N. López‐Canoa ◽  
Rosa M. Agra‐Bermejo ◽  
Esther Díaz‐Rodriguez ◽  
Angel L. Fernandez ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Cholinergic Activity

scholarly journals Association Between Epicardial Adipose Tissue and Atrial Fibrillation

2020 ◽  
Vol 40 (3) ◽  
pp. 149-157
Author(s):  
Ichitaro Abe ◽  
Shinji Miyamoto ◽  
Naohiko Takahashi
Keyword(s):  
Atrial Fibrillation ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue
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