Phagocytic and oxidative burst activity of neutrophils in type 2 diabetic patients with foot ulcers

Biomedicine ◽  
2021 ◽  
Vol 41 (4) ◽  
pp. 776-780
Author(s):  
Grisilda Vidya Bernhardt ◽  
Pooja Shivappa ◽  
Manjula Shantaram ◽  
Varsha Jayakar ◽  
Vinayak Lokapur ◽  
...  
Keyword(s):  
Respiratory Burst ◽  
Phagocytic Activity ◽  
Standard Treatment ◽  
Phagocytic Index ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Short Course ◽  
Type 2 Diabetic

Introduction and Aim: Diabetic foot ulcers are common complications seen in diabetic patients. Treatment of this  disabling foot sore remains a challenge to health care professionals. This study aimed at evaluating whether the neutrophils from type 2 diabetic patients with foot ulcers present an impairment of phagocytic index and impairment in respiratory burst. We also aimed at understanding whether the impairment in neutrophil phagocytic activity can be alleviated with short course of standard treatment regime for foot ulcers.   Methodology: For this case-controled study, 43 participants  with type 2 diabetes  (18  with foot ulcers and 25 without foot ulcers) were prospectively recruited along with 18 healthy volunteers. Phagocytic activity of neutrophils and respiratory burst of neutrophils was assessed  along with ESR, percentage neutrophil counts before and after 2 weeks of standard treatment for foot ulcers.   Results: Neutrophils of type 2 diabetic patients (with and without foot ulcers ) showed  lower levels of phagocytic index and lower percentage of respiratory burst  on  comparison with non-diabetic subjects. Furthermore, on receiving treatment for foot ulcers, a significant improvement in neutrophil phagocytic indices were observed, along with improvement in wound ulcer score.   Conclusion: Phagocytic activity of the neutrophils is impaired  in  type 2 diabetics (with and without foot ulcers). Neutrophil phagocytic indices can be improved on glycemic control. Additionally, improvement in neutrophil phagocytic indices after short course treatment for foot ulcers can be useful markers to predict treatment efficacy and in prognosis of diabetic foot ulcers.

Autologous Skin Fibroblast and Keratinocyte Grafts in the Treatment of Chronic Foot Ulcers in Aging Type 2 Diabetic Patients

2011 ◽  
Vol 101 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Matteo Monami ◽  
Maria Vivarelli ◽  
Carla Maria Desideri ◽  
Giulio Ippolito ◽  
Niccolò Marchionni ◽  
...  
Keyword(s):  
Healing Time ◽  
Lower Limbs ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Consecutive Series ◽  
Type 2 Diabetic Patients ◽  
Skin Cell ◽  
Type 2 Diabetic

Background: We assessed the tolerability and efficacy of autologous skin cell grafts in older type 2 diabetic patients with chronic foot ulcers. Methods: Treatment with Hyalograft 3D and Laserskin Autograft was proposed to a consecutive series of type 2 diabetic patients older than 65 years affected by long-standing (>6 months) foot ulcers with an area greater than 15 cm2. Ulcer healing rates and measurements of ulcer area were determined monthly for 12 months. Results: Seven patients with 12 ulcers, nine of which received the described treatment, were enrolled. During 12-month follow-up, all of the ulcers healed except one. In the remaining eight ulcers, the median healing time was 21 weeks (interquartile range, 4–29 weeks). Conclusions: Autologous skin cell grafts are feasible, well tolerated, and apparently effective in the treatment of diabetic ulcers of the lower limbs in advanced age. Age did not seem to moderate healing times. (J Am Podiatr Med Assoc 101(1): 55–58, 2011)

Malnutrition in type 2 diabetic patients does not affect healing of foot ulcers

2018 ◽  
Vol 56 (2) ◽  
pp. 171-176 ◽  
Author(s):  
A. Rouland ◽  
C. Fourmont ◽  
A. L. Sberna ◽  
L. S. Aho Glele ◽  
T. Mouillot ◽  
...  
Keyword(s):  
Foot Ulcers ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

The Diabetic Person Beyond a Foot Ulcer

2008 ◽  
Vol 98 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Matteo Monami ◽  
Rosella Longo ◽  
Carla Maria Desideri ◽  
Giulio Masotti ◽  
Niccolò Marchionni ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Geriatric Depression Scale ◽  
Depression Scale ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Geriatric Depression ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Background: Several studies have shown a significant relationship between depressive symptoms and wound healing, but these studies have not assessed the effects of depressive symptoms on diabetic foot prognosis. We specifically designed our study to assess the role of depressive symptoms in healing and recurrence of diabetic foot ulcers. Methods: A consecutive series of 80 type 2 diabetic patients aged 60 years and older with foot ulcers was enrolled in a cohort observational study with a 6-month follow-up. Patients who healed within 6 months of enrollment were included in a 12-month follow-up study for assessment of ulcer recurrence. Depressive symptoms were assessed with the geriatric depression scale. Results: Healing was associated with a smaller ulcer area, shorter delay between ulcer onset and treatment, lower glycosylated hemoglobin, and higher ankle-brachial index. Both smoking status and Texas and Wagner scores also had a significant impact on healing. Patients who healed had significantly lower scores on the geriatric depression scale, and those with scores = 10 had a significantly higher risk of not healing at 6 months (relative risk, 3.57; 95% confidence interval, 1.05–12.2). Patients with a recurrent ulcer (59.3%) showed significantly higher total cholesterol levels, higher scores on the Greenfield index of disease severity and geriatric depression scale, and a higher prevalence of cerebrovascular disease. Depressive symptoms maintained a significant association with persistence and recurrence of ulcer even after adjustment for confounders. Conclusions: Depressive symptoms are associated with impaired healing and recurrence of ulcers in elderly type 2 diabetic patients. (J Am Podiatr Med Assoc 98(2): 130–136, 2008)

scholarly journals DIABETIC FOOT ULCERS; CORRELATION OF NUTRITIONAL STATUS OF TYPE 2 DIABETIC PATIENTS OF HYDERABAD SINDH PAKISTAN

2017 ◽  
Vol 24 (05) ◽  
pp. 707-712 ◽  
Author(s):  
Dr. Imran Ali Shaikh ◽  
Dr. Naila Masood ◽  
Dr. Fouzia Aijaz Shaikh ◽  
Dr. Munir A Shaikh
Keyword(s):  
Nutritional Status ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Patients ◽  
Diabetic Foot Ulcers ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic
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