scholarly journals A combination of the neutrophil-to-lymphocyte ratio and the GRACE risk score better predicts PCI outcomes in Chinese Han patients with acute coronary syndrome

2015 ◽  
Vol 15 (12) ◽  
pp. 995-1001 ◽  
Author(s):  
Dong Zhou ◽  
Zhaofei Wan ◽  
Yan Fan ◽  
Juan Zhou ◽  
Zuyi Yuan
Keyword(s):  
Acute Coronary Syndrome ◽  
Risk Score ◽  
Neutrophil To Lymphocyte Ratio ◽  
Chinese Han ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Grace Risk Score

Platelet-to-Lymphocyte Ratio Improves the Predictive Power of GRACE Risk Score for Long-Term Cardiovascular Events in Patients with Acute Coronary Syndrome

Cardiology ◽  
2016 ◽  
Vol 134 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Dong Zhou ◽  
Yan Fan ◽  
Zhaofei Wan ◽  
Wen Wen ◽  
Xinhong Wang ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Risk Score ◽  
Complete Blood Count ◽  
Characteristic Curve ◽  
Rank Correlation ◽  
Positive Association ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Grace Risk Score

Objectives: This study aims to evaluate the relationship between platelet-to-lymphocyte ratio (PLR) and GRACE risk score and to examine whether PLR on admission can improve the predictive value of GRACE risk score for cardiovascular disease (CVD) events in patients with acute coronary syndrome (ACS). Methods: PLR was calculated from the platelet and lymphocyte counts from the complete blood count of 2,230 ACS patients upon admission. The GRACE risk score was also calculated. Results: Spearman's rank correlation demonstrated that GRACE risk score was positively correlated with PLR (r = 0.190, p < 0.001). After a median follow-up period of 58 months, multivariate Cox analysis showed that both GRACE risk score [hazard ratio (HR) 1.092, 95% confidence interval (CI) 1.067-1.117, p < 0.001] and PLR (HR 1.100, 95% CI 1.088-1.112, p < 0.001) could independently predict CVD events. Receiver-operating characteristic curve (ROC) analysis proved that using PLR together with GRACE risk score improved the score from 0.70 (95% CI 0.67-0.73, p < 0.001) when used alone to 0.81 (95% CI 0.79-0.83, p < 0.001) for CVD events and from 0.73 (95% CI 0.70-0.77, p < 0.001) when used alone to 0.80 (95% CI 0.77-0.83, p < 0.001) for all-cause mortality. Conclusions: This study proves, for the first time, a positive association between GRACE risk score and PLR, and that a combination of PLR and GRACE risk score is more effective in predicting CVD events in ACS patients.

GRACE Risk Score Predicts Contrast-Induced Nephropathy in Patients With Acute Coronary Syndrome and Normal Renal Function

Angiology ◽  
2012 ◽  
Vol 64 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Sergio Raposeiras-Roubín ◽  
Pablo Aguiar-Souto ◽  
Cristina Barreiro-Pardal ◽  
Diego López Otero ◽  
Juliana Elices Teja ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Renal Function ◽  
Risk Score ◽  
Normal Renal Function ◽  
Contrast Induced Nephropathy ◽  
Coronary Syndrome ◽  
Grace Risk Score

scholarly journals Predictive Value of Neutrophil-to-Lymphocyte Ratio in Outcomes of Patients with Acute Coronary Syndrome

2018 ◽  
Vol 08 (05) ◽  
pp. 265-275
Author(s):  
Wassam Eldin Hadad El Shafey ◽  
Ahmed Mohamed Emara ◽  
Walaa Farid Mosa ◽  
Khaled Hussein El-Sharnouby
Keyword(s):  
Acute Coronary Syndrome ◽  
Predictive Value ◽  
Neutrophil To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome

scholarly journals Association of neutrophil to lymphocyte ratio (NLR) with angiographic SYNTAX score in patients with non-ST-Segment elevation acute coronary syndrome (NSTE-ACS)

2021 ◽  
Vol 13 (3) ◽  
pp. 216-221
Author(s):  
Mehdi Maleki ◽  
Arezou Tajlil ◽  
Ahmad Separham ◽  
Bahram Sohrabi ◽  
Leili Pourafkari ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Linear Regression ◽  
Multivariate Linear Regression ◽  
Neutrophil To Lymphocyte Ratio ◽  
Syntax Score ◽  
Multivariate Linear Regression Analysis ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Timi Score ◽  
Elevation Acute Coronary Syndrome

Introduction: Considering the role of inflammation in pathogenesis of atherosclerosis, we aimed to investigate the association of presentation neutrophil to lymphocyte ratio (NLR) with complexity of coronary artery lesions determined by SYNTAX score in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods: From March 2018 to March 2019, we recruited 202 consecutive patients, who were hospitalized for NSTE-ACS and had undergone percutaneous coronary intervention in our hospital. The association of presentation NLR with SYNTAX score was determined in univariate and multivariate linear regression analysis. Results: Higher NLR was significantly associated with higher SYNTAX score (beta= 0.162, P=0.021). In addition, older age, having hypertension, higher TIMI score, and lower ejection fraction on echocardiographic examination were significantly associated with higher SYNTAX score. TIMI score had the largest beta coefficient among the studied variables (TIMI score beta=0.302, P<0.001). In two separate multivariate linear regression models, we assessed the unique contribution of NLR in predicting SYNTAX score in patients with NSTE-ACS. In the first model, NLR was significantly contributed to predicting SYNTAX score after adjustment for age, sex, and hypertension as covariates available on patient presentation (beta=0.142, P=0.040). In the second model, NLR was not an independent predictor of SYNTAX score after adjustment for TIMI score (beta=0.121, P=0.076). Conclusion: In NSTE-ACS, presentation NLR is associated with SYNTAX score. However, NLR does not contribute significantly to the prediction of SYNTAX score after adjustment for TIMI score. TIMI risk score might be a better predictor of the SYNTAX score in comparison to NLR.

scholarly journals Predictive efficacy of neutrophil-to-lymphocyte ratio for long-term prognosis in new onset acute coronary syndrome: a retrospective cohort study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yi Yang ◽  
Yanan Xu ◽  
Jun Wang ◽  
Xueqin Zhai ◽  
Haibing Jiang
Keyword(s):  
Acute Coronary Syndrome ◽  
Regression Analysis ◽  
Neutrophil To Lymphocyte Ratio ◽  
Gensini Score ◽  
Cox Regression Analysis ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Coronary Lesions ◽  
New Onset

Abstract Background Inflammation is involved in the pathogenesis and progression of coronary artery diseases (CADs), including acute coronary syndrome. The neutrophil-to-lymphocyte ratio (NLR) has been identified as a novel marker of the pro-inflammatory state. We aimed to evaluate the predictive efficacy of the NLR for the prognosis of patients with new-onset ACS. Methods We retrospectively included consecutive patients with new-onset ACS treated with emergency coronary angiography. NLR was measured at baseline and analyzed by tertiles. The severity of coronary lesions was evaluated by the Gensini score. Correlations of NLR with the severity of CAD and the incidence of major adverse cardiovascular diseases (MACEs) during follow-up were determined. Results Overall, 737 patients were included. The NLR was positively correlated with the severity of coronary lesions as assessed by Gensini score (P < 0.05). During the follow-up period (mean, 43.49 ± 23.97 months), 65 MACEs occurred. No significant association was detected between baseline NLR and the risk of MACEs during follow-up by either Kaplan–Meier or Cox regression analysis. Multivariable logistic regression analysis showed that a higher NLR was independently associated with coronary lesion severity as measured by the Gensini score (1st tertile vs. 3rd tertile hazard ratio [HR]: 0.527, P < 0.001, and 2nd tertile vs. 3rd tertile HR: 0.474, P = 0.025). Conclusions The NLR may be associated with coronary disease severity at baseline but is not associated with adverse outcomes in patients with new-onset ACS. Ethics Approval Number 2019XE0208

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