scholarly journals Intracellular trafficking and secretion of matrix metalloproteinases during macrophage migration

2016 ◽  
Author(s):  
Joan Rohl
Keyword(s):  
Matrix Metalloproteinases ◽  
Intracellular Trafficking ◽  
Macrophage Migration

Implication of matrix metalloproteinases 2 and 9 in ceramide 1-phosphate-stimulated macrophage migration

2016 ◽  
Vol 28 (8) ◽  
pp. 1066-1074 ◽  
Author(s):  
Marta Ordoñez ◽  
Io-Guané Rivera ◽  
Natalia Presa ◽  
Antonio Gomez-Muñoz
Keyword(s):  
Matrix Metalloproteinases ◽  
Macrophage Migration ◽  
Ceramide 1

scholarly journals Three matrix metalloproteinases are required in vivo for macrophage migration during embryonic development

2008 ◽  
Vol 125 (11-12) ◽  
pp. 1059-1070 ◽  
Author(s):  
Matthew L. Tomlinson ◽  
Carla Garcia-Morales ◽  
Muhammad Abu-Elmagd ◽  
Grant N. Wheeler
Keyword(s):  
Matrix Metalloproteinases ◽  
Embryonic Development ◽  
Macrophage Migration

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

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