scholarly journals A case of Takayasu’s arteritis presented with fever of unknown origin: Diagnostic value of 18f-FDG PET/CT imaging

2021 ◽  
Vol 38 (2) ◽  
pp. 208-210
Author(s):  
Sibel Uçak SEMIRGIN ◽  
Oktay YAPICI

Takayasu’s arteritis is a chronic vasculitis of the large vessels and has a rare initial presentation of fever of unknown origin (FUO), renders the condition difficult to diagnose. Fluorodeoxyglucose (FDG) positron-emission tomography-computed tomography (PET-CT) can assist in the early diagnosis of Takayasu’s Arteritis patients with FUO and can improve the prognosis of such patients. In this case report, we describe a 27-year- old female presented with one-month history of FUO, showing heterogeneous increased FDG accumulation along the walls of ascending and arch of aorta, left subclavian artery and right brachiocephalic truncus at PET-CT imaging.

2022 ◽  
Vol 11 (2) ◽  
pp. 386
Author(s):  
Kim-Heang Ly ◽  
Nathalie Costedoat-Chalumeau ◽  
Eric Liozon ◽  
Stéphanie Dumonteil ◽  
Jean-Pierre Ducroix ◽  
...  

Fluorodesoxyglucose Positron Emission Tomography (PET/CT) has never been compared to Chest-Abdomen-Pelvis CT (CAPCT) in patients with a fever of unknown origin (FUO), inflammation of unknown origin (IUO) and episodic fever of unknown origin (EFUO) through a prospective and multicentre study. In this study, we investigated the diagnostic value of PET/CT compared to CAPCT in these patients. The trial was performed between 1 May 2008 through 28 February 2013 with 7 French University Hospital centres. Patients who fulfilled the FUO, IUO or EFUO criteria were included. Diagnostic orientation (DO), diagnostic contribution (DC) and time for diagnosis of both imaging resources were evaluated. One hundred and three patients were included with 35 FUO, 35 IUO and 33 EFUO patients. PET/CT showed both a higher DO (28.2% vs. 7.8%, p < 0.001) and DC (19.4% vs. 5.8%, p < 0.001) than CAPCT and reduced the time for diagnosis in patients (3.8 vs. 17.6 months, p = 0.02). Arthralgia (OR 4.90, p = 0.0012), DO of PET/CT (OR 4.09, p = 0.016), CRP > 30 mg/L (OR 3.70, p = 0.033), and chills (OR 3.06, p = 0.0248) were associated with the achievement of a diagnosis (Se: 89.1%, Sp: 56.8%). PET/CT both orients and contributes to diagnoses at a higher rate than CAPCT, especially in patients with FUO and IUO, and reduces the time for diagnosis.


2009 ◽  
Vol 37 (1) ◽  
pp. 136-145 ◽  
Author(s):  
Niklas Jasper ◽  
Jan Däbritz ◽  
Michael Frosch ◽  
Markus Loeffler ◽  
Matthias Weckesser ◽  
...  

2012 ◽  
Vol 42 (7) ◽  
pp. 834-837 ◽  
Author(s):  
Y. J. Kim ◽  
S. I. Kim ◽  
K-W. Hong ◽  
M. W. Kang

2010 ◽  
Vol 73 (3) ◽  
pp. 518-525 ◽  
Author(s):  
Jiří Ferda ◽  
Eva Ferdová ◽  
Jan Záhlava ◽  
Martin Matějovič ◽  
Boris Kreuzberg

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Yiyan Liu

Patients with HIV infection often have generalized lymphadenopathy and/or other lymphoid proliferation and are at significantly increased risk for lymphoma. This study retrospectively evaluated the diagnostic value of concurrent nasopharyngeal lesion and lymphadenopathy on positron emission tomography-computed tomography (PET-CT) with fluorine-18 fluorodeoxyglucose (FDG PET-CT) imaging. The eligible cases were from patients with HIV infection and lymphadenopathy and referred for FDG PET-CT to evaluate lymphoma or other malignancies prior to pathological investigation. FDG PET-CT images and interpretation reports were correlated with clinical information and pathological diagnoses. Among 22 eligible patients, FDG avid nasopharyngeal lesions were incidentally noted in 7 on PET-CT imaging, and all had lymphomas diagnosed with subsequent biopsies (6 diffuse large B-cell lymphomas and 1 Hodgkin’s lymphoma). In the remaining 15 patients with adenopathy but no visible nasopharyngeal lesion or uptake on PET-CT imaging, 9 had biopsies and lymphomas were diagnosed in 4. The patients with FDG avid retroperitoneal or intra-abdominal lymphadenopathy had a greater possibility of lymphoma, compared to those with adenopathy localized only in the upper torso. Coexistent FDG avid nasopharyngeal lesion and generalized lymphadenoapthy on PET-CT imaging are indicative of a malignant lymphoma rather than benign lymphproliferative disease or nasopharyngeal carcinoma.


2020 ◽  
Vol 20 (5) ◽  
pp. 449-453 ◽  
Author(s):  
Wan Zhu ◽  
Wenxia Cao ◽  
Xuting Zheng ◽  
Xuena Li ◽  
Yaming Li ◽  
...  

2014 ◽  
Vol 41 (10) ◽  
pp. 1916-1923 ◽  
Author(s):  
Gijsbert J. Blokhuis ◽  
Chantal P. Bleeker-Rovers ◽  
Marije G. Diender ◽  
Wim J. G. Oyen ◽  
Jos M. Th. Draaisma ◽  
...  

2021 ◽  
Vol 10 (7) ◽  
pp. 1519
Author(s):  
Jean Maillot ◽  
Jean-Valère Malfuson ◽  
Thierry Lazure ◽  
Stéphane Benoist ◽  
Anne Cremades ◽  
...  

Splenectomy is indicated in cases of trauma to the spleen or hematological and immunological diseases (hereditary spherocytosis, autoimmune cytopenia). Less frequently, splenectomy is performed for diagnostic purposes to complement unsuccessful prior etiological investigations. The splenectomy remains a surgery at risk of complications and should be considered as a last-resort procedure to make the diagnosis and to be able to treat patients. We studied the medical files of 142 patients who underwent a splenectomy for any reason over a 10-year period and identified 20 diagnostic splenectomies. Diagnostic splenectomies were mainly performed to explore unexplained splenomegaly for 13 patients and fever of unknown origin for 10. The other patients had surgery for other causes (cytopenia, abdominal symptoms, suspicion of relapsing malignant hemopathies). Splenectomy contributed to the final diagnosis in 19 of 20 cases, corresponding mostly to lymphoid hemopathies (14/20). The most frequent disease was diffuse large B-cell lymphoma (8/20). Splenectomy did not reveal any infectious disease. The most relevant pre-operative procedures to aid the diagnosis were 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and immuno-hematological examinations. Diagnostic splenectomy is useful and necessary in certain difficult diagnostic situations. Highlights: Diagnostic splenectomy is still useful in 2020 to diagnose unexplained splenomegaly or fever of unknown origin. Lymphoma was the most common final diagnosis. FDG PET/CT was the most useful tool to aid in the diagnosis.


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