First Step Towards Enhancement of Searching Within Medical Curriculum in Czech Language using Morphological Analysis

Structural and Chemical Studies of Pathological Fibers in Human Neurofibrillary Degeneration

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010012031x ◽

1985 ◽

Vol 43 ◽

pp. 726-729

Author(s):

K.S. Kosik ◽

L.K. Duffy ◽

S. Bakalis ◽

C. Abraham ◽

D.J. Selkoe

Keyword(s):

Monoclonal Antibodies ◽

Alzheimer Disease ◽

Human Brain ◽

Neurofibrillary Tangles ◽

Morphological Analysis ◽

High Specificity ◽

Cytoskeletal Proteins ◽

Neuritic Plaque ◽

Protein Chemistry ◽

Chemical Studies

The major structural lesions of the human brain during aging and in Alzheimer disease (AD) are the neurofibrillary tangles (NFT) and the senile (neuritic) plaque. Although these fibrous alterations have been recognized by light microscopists for almost a century, detailed biochemical and morphological analysis of the lesions has been undertaken only recently. Because the intraneuronal deposits in the NFT and the plaque neurites and the extraneuronal amyloid cores of the plaques have a filamentous ultrastructure, the neuronal cytoskeleton has played a prominent role in most pathogenetic hypotheses.The approach of our laboratory toward elucidating the origin of plaques and tangles in AD has been two-fold: the use of analytical protein chemistry to purify and then characterize the pathological fibers comprising the tangles and plaques, and the use of certain monoclonal antibodies to neuronal cytoskeletal proteins that, despite high specificity, cross-react with NFT and thus implicate epitopes of these proteins as constituents of the tangles.

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Complementary and alternative medicine (CAM) in the undergraduate medical curriculum: the Southampton experience

Medical Education ◽

10.1046/j.1365-2923.2001.00762.x ◽

2001 ◽

Vol 35 (1) ◽

pp. 73-77 ◽

Cited By ~ 19

Author(s):

David Owen ◽

George T Lewith

Keyword(s):

Alternative Medicine ◽

Complementary And Alternative Medicine ◽

Medical Curriculum ◽

Undergraduate Medical Curriculum ◽

Complementary And Alternative

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Integration of Medical Informatics with Other Courses in the Medical Curriculum

Methods of Information in Medicine ◽

10.1055/s-0038-1636796 ◽

1989 ◽

Vol 28 (04) ◽

pp. 243-245 ◽

Cited By ~ 3

Author(s):

C. Tumstra

Keyword(s):

Medical School ◽

Medical Informatics ◽

Medical Curriculum ◽

New Curriculum ◽

The Way

Abstract:The introduction of a new structure in the Medical Curriculum at the Leiden University Medical School has facilitated the integration of medical informatics subjects with other subjects. The paper describes the holistic nature of the new curriculum, the way Medical Informatics is interwoven with other subjects and the problems which have been encountered.

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