scholarly journals Childhood Guillain-Barré Syndrome’s Subtypes and Outcome: A Single Centre Experience

2021 ◽  
Author(s):  
Özben Akıncı Göktaş ◽  
Ömer Bektaş ◽  
Merve Feyza Yüksel ◽  
Süleyman Şahin ◽  
Serap Teber
Keyword(s):  
Cranial Nerve ◽  
Ventilatory Support ◽  
Guillain Barre Syndrome ◽  
Clinical Scale ◽  
Cranial Nerve Involvement ◽  
Female Ratio ◽  
Nerve Involvement ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

INTRODUCTION: In this study, we aimed to revise the clinical, epidemiologic and prognostic features of childhood Guillain-Barré syndrome. METHODS: Thirty two children admitted to our hospital and diagnosed with Guillain-Barré syndrome between June 2007- November 2019 were enrolled in the study. We also administered clinical evaluation scale at onset, discharge, 1,3,6 and 12 months after discharge. RESULTS: The median age was 72.22 months (range from 6 to 202 months) with a male to female ratio of 1.46. Based on electrophysiological features; 22 patients were classified as acute inflammatory demyelinating polyradiculoneuropathy, 10 as acute motor axonal neuropathy. The incidence of cranial nerve involvement was 28.1 % and was related to lower clinical scale score at admission and discharge. Clinical scale scores were significantly different between axonal and demyelinating subgroups except for admission. At 12th month follow-up visit, 78.1% of patients were recovered without sequal. DISCUSSION AND CONCLUSION: We think that the most important predictor of morbidity is predicting the possible ventilatory support need during the follow up period. Short incubating period of antecedent infection and cranial nerve involvement will probably increase ventilatory support need. The prognosis was found to be significantly different between electrophysiological subtypes in our series, axonal forms being consistent with poor prognosis.

scholarly journals Cranial Nerve Involvement and Dysautonomia in Post-COVID-19 Guillain-Barré Syndrome

2021 ◽  
Author(s):  
Toshiyuki Kakumoto ◽  
Satoshi Kobayashi ◽  
Hayato Yuuki ◽  
Mitsuhiro Kainaga ◽  
Yuichiro Shirota ◽  
...  
Keyword(s):  
Cranial Nerve ◽  
Guillain Barre Syndrome ◽  
Cranial Nerve Involvement ◽  
Nerve Involvement ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Twelfth Cranial Nerve Involvement in Guillain-Barre Syndrome: A Case Report

2020 ◽  
Vol 26 (4) ◽  
pp. 353-356
Author(s):  
Gizem Çifter ◽  
Gholamreza Hoseinzadeh ◽  
Elif Simin Issı ◽  
Demet İlhan Algın ◽  
Oğuz Osman Erdinç
Keyword(s):  
Case Report ◽  
Cranial Nerve ◽  
Guillain Barre Syndrome ◽  
Cranial Nerve Involvement ◽  
Nerve Involvement ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Case Report and Literature Analysis: Guillain-Barré Syndrome With Delayed Unilateral Facial Palsy

2021 ◽  
Vol 12 ◽  
Author(s):  
Xuanyu Huang ◽  
Ziwei Lan ◽  
Yajing Zhan ◽  
Zhiping Hu
Keyword(s):  
Facial Nerve ◽  
Facial Palsy ◽  
Guillain Barre Syndrome ◽  
Facial Movement ◽  
Cranial Nerve Involvement ◽  
Nerve Involvement ◽  
Rare Manifestation ◽  
Guillain Barré Syndrome ◽  
Ganglioside Antibodies ◽  
Guillain Barré

Guillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy in which most patients have cranial nerve involvement, with facial nerve involvement being the most common. However, delayed facial palsy (DFP) with asymmetric facial palsy is a rare manifestation of GBS, and the mechanism is unclear. We report a case of GBS combined with delayed unilateral facial palsy and review previously reported cases of GBS combined with DFP. A total of 28 cases of GBS with DFP, including the case in this report, were included in this study. The occurrence of DFP may be related to early subclinical demyelination of the facial nerve, the blood-nerve barrier of the facial nerve, facial movement, and descending reversible paralysis. The occurrence of unilateral facial palsy may be related to Campylobacter jejuni, specific anti-ganglioside antibodies, and the site of central nervous system anatomical involvement. There is no evidence that immunotherapy is related to the shortening of DFP course and improving patients' prognosis.

Study of Guillain-Barre syndrome etiology in Pakistani patients

2021 ◽  
Author(s):  
Rashid Iqbal ◽  
Muhammad Javaid Asad ◽  
Saima Siddiqi ◽  
Raja Tahir Mahmood ◽  
Muhamamd Baseer Shah ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Nerve Conduction ◽  
Treatment Strategies ◽  
Guillain Barre Syndrome ◽  
Clinical Feature ◽  
Interleukin 17 ◽  
Healthy Controls ◽  
Female Ratio ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Objective: To examine clinical features, biochemical markers, demographic features, antecedent infections, frequency and treatment strategies. Methods: This case-control study was conducted at Pakistan Institute of Medical Sciences (PIMS), Islamabad, Pakistan and District Headquarters Hospital (DHQ), Rawalpindi, Pakistan from 2018 to 2020. Ninety consecutive patients of Guillain-Barré syndrome (GBS) and 77 healthy controls were enrolled. Patients were diagnosed by clinical presentation, Nerve conduction study (NCS), Electromyography (EMG), Cerebrospinal fluid analysis (CSF) and biochemical profile. Data was analyzed on IBM SPSS version 23. Results: Symmetrical ascending weakness was the striking clinical feature. Mean age was 40.20±14.90 years and male to female ratio was 2.1:1. Acute inflammatory demyelinating polyneuropathy (AIDP) was found to be the most common electrophysiological variant of GBS (46%). There was considerable difference in Interleukin-17(IL-17) levels between GBS patients 23.12 ± 3.41 pg/ml and healthy controls 8.82 ± 2.49. Mean IL-17 level was markedly increased in GBS patients, P=0.006, P<0.05. Gastrointestinal infection was the most common preceding infection (56.66%). Mean CSF protein was 100.83 g/dl with ± 51.32 standard deviation and albumio cytologic dissociation (ACD) was different in all four variants of GBS, P= 0.005. Conclusion: GBS was presented by all ages. Males were more affected than females. About two third of GBS patients showed an antecedent infection before GBS onset. Increased levels of cytokine (IL-17) showed involvement of autoimmunity. ACD differentiated it from poliomyelitis. Plasmapheresis and intravenous immunoglobulin (IVIG) therapy were used to treat patients. Key words: Guillain-Barré Syndrome; cerebrospinal fluid; albuminocytologic dissociation; nerve conduction studies; variants; electromyography Continuous....

scholarly journals A Case Report on Post COVID -19 Vaccine Associated Guillain–Barré Syndrome

2021 ◽  
pp. 454-458
Author(s):  
S. Hemalatha ◽  
M. Karishma ◽  
J. Bera ◽  
S. Blessy ◽  
J. Thirumaran ◽  
...  
Keyword(s):  
Case Report ◽  
Nerve Conduction ◽  
Muscle Power ◽  
Ventilatory Support ◽  
Infectious Agent ◽  
Guillain Barre Syndrome ◽  
Autonomic Nerves ◽  
Intravenous Immunoglobulin Therapy ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Guillain–Barré syndrome (GBS) is an autoimmune demyelinating illness in which a patient’s immune system attacks and cause deterioration of peripheral nervous system leading to progressive paralysis and polyneuropathy. The exact cause of the GBS is unclear but the main mechanism of behindis the demyelination of nerves especially the motor, sensory, and autonomic nerves which can be triggered by any immunologic or infectious agent. The infectious agent elicits the humoral and cellular mediated immune response due to their molecular mimicry in which the antibodies created against the infection matches with the proteins on the nerve. The characteristic features of Guillain–Barré syndrome are ascending flaccid paralysis, paresthesia, impairment of muscle reflexes, respiratory failureetc. The GBS is diagnosed via nerve conduction studies, lumbar puncture (Cerebrospinal fluid analysis), electromyography, Brighton criteria. Treatments like intravenous immunoglobulin therapy, plasma exchange can ease the symptoms and reduce the duration of the illness. This case report focusing on a 43-year-old female patient admitted seeking ventilatory support for respiratory distress caused by Guillain–Barré Syndrome in a tertiary hospital. Patient had developed limb weakness with ascending paralysis along with facial weakness within a couple of weeks after receiving the COVID -19 vaccination (COVISHIELD)one month back. Patient underwent nerve conduction study and routine monitoring of vital parameters. After conservative management with physiotherapy, ventilation, intravenous immunoglobulins and prophylaxis for pain and DVT patient gradually started improving the muscle power and was discharged to continue the rehabilitation care at home.

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