Impact of ageing on female metabolic flexibility: a cross-sectional pilot study in over-60 active women

Background Ageing influences the metabolic flexibility, albeit the physical status could determine this relationship. This cross-sectional study aims to describe and analyse the metabolic flexibility/inflexibility in a group of active older women, together with the impact of ageing and physical status on their oxidation rates and maximal fat oxidation (MFO). Methods Fifteen volunteers (69.00±6.97 years) from 24 women, completed an incremental cycling test until the second ventilatory threshold. Intensity increased 10W each 3min–15sec, starting at 30W. Gas exchange, heart rate, rate of perceived effort, pain scale and muscle power were registered, together with lactate. VO2 and VCO2 were considered for Fat and CHO oxidation (FATox & CHOox; Frayn’s equation) at the intensities 60%, 80% and 100% from the peak of power in the test (P100). Psychophysiological parameters were compared at MFO/FATmax and P100, together with the main correlation analyses, with and without P100 and VO2 as covariates. Results FATox was low at MFO (0.13; 95%CI [0.09-0.17] g·min−1·kg; 5.61 [3.59-7.63] g·min−1·kg FFM), with a shifting down and leftward of a short oxidation-rate curves. CHOox and FATox were both low for a reduced power with age (77.14±18.58 W & 39.29±9.17 W at P100 and MFO respectively), pointing to metabolic inflexibility in older women despite being active. Notwithstanding, the negative correlation between age and MFO (r=-0.54, p=0.04; R2=0.29) disappeared when normalized with P100 (r=-0.17, p=0.53), which was in turn strongly and negatively associated to age (r=-0.85, p<0.005; R2=0.72). P100 was also positive and moderately associated to MFO (r=0.71, p=0.01; R2=0.50). Conclusions Despite the inflexibility with age, physical status (i.e., larger muscular power) suggest a key role in the preservation of the metabolic health with aging in active women.

Survei Kondisi Fisik Sepak Bola pada Pemain Arema Football Academy Usia 16 Tahun di Kota Malang Tahun 2021

Physical condition is an important role in football because with good physical condition, it will be more likely to achieve. This study aims to determine the level of physical condition of Arema players aged 16 years in Malang City in 2021. The method used in this study is descriptive quantitative which aims to provide a real picture in accordance with what is in the field about the physical condition of Arema Football Academy football players aged 16 years old in Malang in 2021. The results on leg muscle strength have an average of 44.24, speed has an average of 7.73, agility has an average of 9.91, flexibility has an average of 16.60, muscle power limbs have an average of 55.88, endurance has an average of 45.98. It can be concluded that strength (leg muscles) is in sufficient category, speed is in good category, agility is in very good category, flexibility is in very good category, leg muscle power is in good category and endurance is in good category. And the overall physical condition is in the sufficient category. Abstrak: Kondisi fisik merupakan peranan yang penting dalam sepak bola karena dengan kondisi fisik yang baik maka akan lebih berpeluang untuk berprestasi. Penelitian ini bertujuan untuk mengetahui tingkat kondisi fisik pemain arema usia 16 tahun di Kota Malang tahun 2021. Metode yang digunakan dalam penelitian ini merupakan kuantitatif deskriptif yang bertujuan untuk memberikan gambaran nyata sesuai dengan yang ada di lapangan tentang kondisi fisik pemain sepak bola Arema Football Academy umur 16 tahun di Kota Malang tahun 2021. Hasil pada kekuatan otot tungkai memiliki rata-rata 44,24, kecepatan memiliki rata-rata 7,73, kelincahan memiliki rata-rata 9,91, kelentukan memiliki rata-rata 16,60, power otot tungkai memiliki rata-rata 55,88, daya tahan memiliki rata-rata 45,98. Dapat disimpulkan bahwa kekuatan (otot tungkai) masuk kategori cukup, kecepatan masuk kategori baik, kelincahan masuk kategori baik sekali, kelentukan masuk kategori baik sekali, power otot tungkai masuk kategori baik dan daya tahan masuk kategori baik. Dan pada kondisi fisik secara keseluruhan masuk dalam kategori cukup.

Glucocorticoid-Induced Hypokalemic Periodic Paralysis after Short-Term Use of Tenofovir with Hypophosphatemia: A Case Report

Hypokalemic periodic paralysis (HPP) is a neuromuscular disorder associated with muscular dysfunction caused by hypokalemia. There are various causes of HPPs and rarely, HPP appears to be relevant to tenofovir or glucocorticoid treatment. There have been several case reports of tenofovir-related nephrotoxicity or tenofovir-induced HPP. However, a case report of glucocorticoid-induced HPP in a patient using tenofovir temporarily has not been reported. Herein, we report a case of glucocorticoid-induced HPP with short-term use of tenofovir. A 28-year-old man visited the emergency room with decreased muscle power in all extremities (2/5 grade). In their past medical history, the patient was treated with tenofovir for two months for a hepatitis B virus infection. At the time of the visit, the drug had been discontinued for four months. The day before visiting the emergency room, betamethasone was administered at a local clinic for herpes on the lips. Laboratory tests showed hypokalemia, hypophosphatemia, and mild metabolic acidosis. However, urinalysis revealed no abnormal findings. Consequently, it can be postulated that this patient developed HPP by glucocorticoids after taking tenofovir temporarily. This is the first case report of glucocorticoid-induced HPP in a patient using tenofovir. Clinicians who prescribe tenofovir should be aware of HPP occurring when glucocorticoids are used.

Isokinetic and functional shoulder outcomes after arthroscopic capsulolabral stabilization

Introduction Shoulder stability is secured by dynamic and static stabilizers. Rotator cuff is responsible for dynamic stabilization. In cases of shoulder instability their activity is disturbed. Capsulolabral repair restores mainly static stabilization. This surgery treatment technique of shoulder instability was first described by Bankart in 1923. His idea, with further modifications, is commonly used up to this day. Evaluation of muscle shoulder recovery after stabilization should be one of the important criteria to allow patient to return to sport and work. However, not much isokinetic assessment after capsulolabral repair was described. The aim of this study were the following: the comparative assessment of the shoulder rotatory strength in patients following arthroscopic capsulolabral repair of unilateral anterior traumatic instability and clinical assessment with comparison of pre and post-operative results. Material and methods Forty-five patients, 14 women and 31 men, with an average follow-up of 4.4 years were tested bilaterally for internal and external rotation strength at four angular velocities. ASES and UCLA tests were collected before and after surgery. Results The values of peak moment and muscle power parameters were slightly lower for an operated shoulder in comparison to a healthy shoulder for the external rotation. Total work parameter in external rotation was significantly lower for the operated shoulder in comparison to the non-operated side. The internal/external muscle group balance was lower for the operated shoulder in comparison to reference values in the women group. Furthermore, both ASES and UCLA scores were significantly higher after operation. Conclusions After arthroscopic capsulolabral shoulder stabilization, slight differences in isokinetic evaluation, especially in external shoulder rotation, occur. It affects rotators muscle balance. In functional evaluation significant improvement in shoulder function occurs.

A Case Report on Post COVID -19 Vaccine Associated Guillain–Barré Syndrome

Guillain–Barré syndrome (GBS) is an autoimmune demyelinating illness in which a patient’s immune system attacks and cause deterioration of peripheral nervous system leading to progressive paralysis and polyneuropathy. The exact cause of the GBS is unclear but the main mechanism of behindis the demyelination of nerves especially the motor, sensory, and autonomic nerves which can be triggered by any immunologic or infectious agent. The infectious agent elicits the humoral and cellular mediated immune response due to their molecular mimicry in which the antibodies created against the infection matches with the proteins on the nerve. The characteristic features of Guillain–Barré syndrome are ascending flaccid paralysis, paresthesia, impairment of muscle reflexes, respiratory failureetc. The GBS is diagnosed via nerve conduction studies, lumbar puncture (Cerebrospinal fluid analysis), electromyography, Brighton criteria. Treatments like intravenous immunoglobulin therapy, plasma exchange can ease the symptoms and reduce the duration of the illness. This case report focusing on a 43-year-old female patient admitted seeking ventilatory support for respiratory distress caused by Guillain–Barré Syndrome in a tertiary hospital. Patient had developed limb weakness with ascending paralysis along with facial weakness within a couple of weeks after receiving the COVID -19 vaccination (COVISHIELD)one month back. Patient underwent nerve conduction study and routine monitoring of vital parameters. After conservative management with physiotherapy, ventilation, intravenous immunoglobulins and prophylaxis for pain and DVT patient gradually started improving the muscle power and was discharged to continue the rehabilitation care at home.

Effect of muscle power training on fall risk in older adults: A systematic review and meta-analysis

Review question / Objective: P: Older adults; I: Power training; C: Other type of exercise program; O: Fall Risk. Objective: To describe the effectiveness of muscle power training on fall risk in older adults. Condition being studied: Healthy older adults or those with different pathologies who undergo a muscle power training program for the prevention of falls. Eligibility criteria: Inclusion Criteria: Randomized Controlled Trial (RCT); Adults over 60 years of age, living independently in the community without disabilities and other diseases that make them unsuitable for exercise interventions; muscle power training of the lower limbs, without combining it with other types of exercise; Outcome: Fall Risk. Exclusion Criteria: Studies that used ergogenic drugs or aids; studies that manipulated diet; conference presentations, theses, books, editorials, review articles, and expert opinions; missing full text or incomplete data on outcome indicators.

Light Electric Vehicles for Muscle–Battery Electric Mobility in Circular Economy: A Comprehensive Study

Light electric vehicles (LEVs) facilitate a significant reduction in global warming potential (GWP) and other environmental impacts related to specific transport performance due to their lightweight construction. Low-voltage systems in the drive engine, an open vehicle design and online vehicle data processing allow LEVs to be repaired by independent workshops, thus enabling long vehicle use as well as conversion or retrofitting for periods of use beyond 20 years. LEVs are not yet very common in everyday life in Western Europe. In order to support the acceptance of muscle power-supported LEVs in the EU L7e registration class by users, the vehicle design and construction specifically address requirements in the areas of last-mile parcel delivery and other transport services, including passenger transport. Life cycle assessment was used to investigate two construction methods for LEVs, mixed construction and fibre composite construction, in terms of the production, service life phase and end of life. A vehicle configuration was developed which, in addition to resource-saving production and long-life operation, enables easy access for users and maintenance of the LEV for various purposes. The resource efficiency of light electric vehicles was proven with regard to the ecological aspects. The vehicle design shown here shows high potential for LEVs in the circular economy.