The Diagnostic Value Of Anti-Cyclic Citrullinated Peptide And Rheumatoid Factor In Rheumatoid And Psoriatic Arthritis

Objective This meta-analysis explored the diagnostic value of anti-cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor (RF) for rheumatoid arthritis (RA) in the Asian population. Methods Embase, Medline, Cochrane Library, Chinese Science and Technology Periodicals, China National Knowledge Infrastructure, and China Wanfang Databases were searched from 1 January 2000 to 1 February 2021 to collect studies on the combined detection of anti-CCP and RF for diagnosing RA. The sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (+LR), and negative likelihood ratio (−LR) were combined and analyzed. Summary receiver operating characteristic (SROC) curves were drawn. Results Twenty-four published papers were analyzed, including 21 combined in series and 8 combined in parallel. In the tandem analysis, the sensitivity = 0.64 [95% confidence interval (CI): 0.58–0.70], specificity = 0.97 (95%CI: 0.95–0.98), +LR = 19.70 (95%CI: 12.74–30.46), −LR = 0.37 (95%CI: 0.31–0.43), DOR = 53.43 (95%CI: 34.46–82.40), and area under the SROC curve = 0.89. In the parallel combination, the sensitivity = 0.87 (95%CI: 0.80–0.92), specificity = 0.76 (95%CI: 0.67–0.84), +LR = 3.68 (95%CI: 2.62–5.17), −LR = 0.17 (95%CI: 0.11–0.26), DOR = 21.56 (95%CI: 11.63–39.99), and area under the SROC curve = 0.89. Conclusion Anti-CCP and RF combined detection improves the diagnostic efficiency of RA, providing a potential strategy for early clinical screening in the Asian population. This trial was retrospectively registered in the INPLASY/Research Registry ( https: //inplasy.com/ ) with the registration number INPLASY202180106.

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RHEUMATOID FACTOR AND ANTI-CYCLIC CITRULLINATED PEPTIDE ANTIBODIES IN PATIENTS WITH PSORIATIC ARTHRITIS

Rheumatology Science and Practice ◽

10.14412/1995-4484-2011-1458 ◽

2011 ◽

Vol 0 (5) ◽

pp. 32

Author(s):

V. V. Badokin ◽

I. A. Troshkina ◽

E. N. Alexandrova

Keyword(s):

Psoriatic Arthritis ◽

Rheumatoid Factor ◽

Cyclic Citrullinated Peptide ◽

Citrullinated Peptide ◽

Peptide Antibodies

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Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in Rheumatoid Arthritis

ACTUALIDAD MEDICA ◽

10.15568/am.2021.813.or02 ◽

2021 ◽

Vol 106 (106(813)) ◽

pp. 157-164

Author(s):

R. Clavero-López ◽

A.I. Navarro-Abad ◽

M. Ruiz-Herance ◽

J.M. Urra-Ardanaz

Keyword(s):

Rheumatoid Arthritis ◽

Rheumatoid Factor ◽

Pharmacological Treatment ◽

Test Validity ◽

Reference Value ◽

Diagnostic Value ◽

Definitive Diagnosis ◽

Cyclic Citrullinated Peptide ◽

Citrullinated Peptide ◽

Peptide Antibodies

Introduction: For the diagnosis of Rheumatoid Arthritis (RA), the detection of the autoantibodies, rheumatoid factor (FR) and cyclic citrullinated peptide antibodies (APCC) are used. The presence of these antibodies determines that the RA is classified as seropositive or seronegative, with important implications both in the clinical development and in the prognosis of the disease. Objective: To assess the role of APCC and RF in the diagnosis of RA, as well as its influence on the establishment of pharmacological treatment. Methodology: We studied 213 patients with initial clinical suspicion of RA and with determinations of FR and APCC. Their definitive diagnosis and the pharmacological treatment established were studied. Results: 63 of 213 patients had a definitive diagnosis of RA. 77.8% were classified as seropositive. The sensitivity and specificity were higher in the APCC compared to FR. Initially the RF presented a low diagnostic value since it was negative in more than two thirds of the patients with a diagnosis of RA. The precise adjustment of its reference value allowed its use as a useful diagnostic tool. The presence of antibodies in patients with RA influences the treatment of choice with an increased use of Methotrexate against other immunosuppressants in seropositive patients. Conclusions: The APCC presented better parameters of diagnostic test validity than the RF. The presence of antibodies in RA influences the treatment of choice possibly due to the greater severity of the pathology.

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Rheumatoid Factor, Anti-cyclic Citrullinated Peptide and HLA-B Locus Antigens in Psoriatic Arthritis Patients in Bangladesh

Journal of Shaheed Suhrawardy Medical College ◽

10.3329/jssmc.v12i2.56892 ◽

2022 ◽

Vol 12 (2) ◽

pp. 109-114

Author(s):

Devolina Bhowmik ◽

Manash Chandra Sarker ◽

Shirin Tarafder ◽

Hosne Jahan ◽

Mst Naznin Tarana ◽

...

Keyword(s):

Psoriatic Arthritis ◽

Rheumatoid Factor ◽

Human Leukocyte ◽

Cross Sectional Study ◽

P Value ◽

Serum Samples ◽

Cross Sectional ◽

Cyclic Citrullinated Peptide ◽

B Locus ◽

Citrullinated Peptide

Introduction: Psoriatic arthritis (PsA) is established as a multifactorial disease resulting from a complex interplay between genetic, environmental and immunological factors. It is a seronegative arthritis but rheumatoid factor may be present in up to 15% of PsA patients Antibodies recognizing a cyclic citrullinated peptide are highly speciûc for rheumatoid arthritis (RA) but their role in PsA remains unclear. An increased prevalence of anti-CCP antibody in PsA is also reported. Study shows that HLA-DRB1 shared epitope is signiûcantly associated with the presence of anti-CCP antibody in PsA patients but this type of association is not found with other human leukocyte antigens. Objectives: The aim of this study was to investigate the frequency of anti-CCP and RF in PsA patients and their associations with HLA-B locus antigens. Methods: In this cross sectional study, we selected 50 unrelated consecutive patients with PsA according to CASPAR criteria for PsA. 6 ml of blood was collected from each patient for HLAB locus typing, RA test and test for anti-CCP. Patient’s serum samples were tested for RF by Nephelometric system and tests for anti-CCP were done by ELISA. HLA-B locus typing was done by PCR with sequence specific primer. Results: Among 50 PsA patients, 27 (54%) are female and 23 (46%) are male. RA test is positive in 10 (20%) patients and anti-CCP is positive in 7 (14%) patients. Significant association was found between HLA-B*37 and RF (p value= < 0.001). Conclusion: RF is present in 10 (20%) and anti-CCP is present in 7 (14%) PsA patients. HLAB* 37 was significantly found in RF positive patients. J Shaheed Suhrawardy Med Coll 2020; 12(2): 109-114

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