Shorter Versus Longer Durations of Any Human Milk Feeding and Cardiovascular Disease Outcomes in Offspring: A Systematic Review

ABSTRACT Background During the Pregnancy and Birth to 24 Months Project, the US Departments of Agriculture and Health and Human Services initiated a review of evidence on diet and health in these populations. Objectives The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding, and 4) lower versus higher intensities of human milk fed to mixed-fed infants with intermediate and endpoint cardiovascular disease (CVD) outcomes in offspring. Methods The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January 1980–March 2016, dual-screened the results using predetermined criteria, extracted data from and assessed the risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence. Results The 4 systematic reviews included 13, 24, 6, and 0 articles, respectively. The evidence was insufficient to draw conclusions about endpoint CVD outcomes across all 4 systematic reviews. Limited evidence suggests that never versus ever being fed human milk is associated with higher blood pressure within a normal range at 6–7 y of age. Moderate evidence suggests there is no association between the duration of any human milk feeding and childhood blood pressure. Limited evidence suggests there is no association between the duration of exclusive human milk feeding and blood pressure or metabolic syndrome in childhood. Additional evidence about intermediate outcomes for the 4 systematic reviews was scant or inconclusive. Conclusions There is insufficient evidence to draw conclusions about the relationships between infant milk-feeding practices and endpoint CVD outcomes; however, some evidence suggests that feeding less or no human milk is not associated with childhood hypertension.

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Feeding a Lower Versus Higher Intensity, Proportion, or Amount of Human Milk to Mixed-Fed Infants and Cardiovascular Disease Outcomes in Offspring: A Systematic Review

10.52570/nesr.pb242018.sr0213 ◽

2019 ◽

Author(s):

Darcy Güngör ◽

Perrine Nadaud ◽

Carol Dreibelbis ◽

Concetta LaPergola ◽

Nancy Terry ◽

...

Keyword(s):

Systematic Review ◽

Cardiovascular Disease ◽

Human Milk ◽

Disease Outcomes

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Vegetarian Diets with Cardiovascular Disease Outcomes: A Systematic Review and Meta-Analyses of Prospective Cohort Studies

Canadian Journal of Diabetes ◽

10.1016/j.jcjd.2018.08.056 ◽

2018 ◽

Vol 42 (5) ◽

pp. S20

Author(s):

Andrea Glenn ◽

Effie Viguiliouk ◽

Maxine Seider ◽

Sonia Blanco Mejia ◽

Cyril Kendall ◽

...

Keyword(s):

Systematic Review ◽

Cardiovascular Disease ◽

Cohort Studies ◽

Prospective Cohort ◽

Prospective Cohort Studies ◽

Disease Outcomes ◽

Vegetarian Diets ◽

Meta Analyses

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Infant milk-feeding practices and childhood leukemia: a systematic review

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqy306 ◽

2019 ◽

Vol 109 (Supplement_1) ◽

pp. 757S-771S ◽

Cited By ~ 3

Author(s):

Darcy Güngör ◽

Perrine Nadaud ◽

Carol Dreibelbis ◽

Concetta C LaPergola ◽

Yat Ping Wong ◽

...

Keyword(s):

Systematic Review ◽

Human Milk ◽

Systematic Reviews ◽

Childhood Leukemia ◽

Lymphoblastic Leukemia ◽

Surveillance Systems ◽

Limited Evidence ◽

Cancer Data ◽

Review Team ◽

Milk Feeding

ABSTRACTBackgroundDuring the Pregnancy and Birth to 24 Months Project, the US Departments of Agriculture and Health and Human Services initiated a review of evidence on diet and health in these populations.ObjectivesThe aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding, and 4) feeding a lower versus higher intensity of human milk to mixed-fed infants with acute childhood leukemia, generally, and acute lymphoblastic leukemia, specifically.MethodsThe Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January 1980 to March 2016, dual-screened the results using predetermined criteria, extracted data from and assessed risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence.ResultsWe included 24 articles from case-control or retrospective studies. Limited evidence suggests that never feeding human milk versus 1) ever feeding human milk and 2) feeding human milk for durations ≥6 mo are associated with a slightly higher risk of acute childhood leukemia, whereas evidence comparing never feeding human milk with feeding human milk for durations <6 mo is mixed. Limited evidence suggests that, among infants fed human milk, a shorter versus longer duration of human milk feeding is associated with a slightly higher risk of acute childhood leukemia. None of the included articles examined exclusive human milk feeding or the intensity of human milk fed to mixed-fed infants.ConclusionsFeeding human milk for short durations or not at all may be associated with slightly higher acute childhood leukemia risk. The evidence could be strengthened with access to broadly generalizable prospective samples; therefore, we recommend linking surveillance systems that collect infant feeding and childhood cancer data.

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Infant milk-feeding practices and diabetes outcomes in offspring: a systematic review

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqy311 ◽

2019 ◽

Vol 109 (Supplement_1) ◽

pp. 817S-837S ◽

Cited By ~ 4

Author(s):

Darcy Güngör ◽

Perrine Nadaud ◽

Concetta C LaPergola ◽

Carol Dreibelbis ◽

Yat Ping Wong ◽

...

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Human Milk ◽

Systematic Reviews ◽

Limited Evidence ◽

Diabetes Outcomes ◽

Intermediate Outcomes ◽

Milk Feeding

ABSTRACTBackgroundDuring the Pregnancy and Birth to 24 Months Project, the US Departments of Agriculture and Health and Human Services initiated a review of evidence on diet and health in these populations.ObjectivesThe aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding, and 4) feeding a lower versus higher intensity of human milk to mixed-fed infants with type 1 and type 2 diabetes in offspring.MethodsThe Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January 1980–March 2016, dual-screened the results according to predetermined criteria, extracted data from and assessed the risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence.ResultsThe 4 systematic reviews included 21, 37, 18, and 1 articles, respectively. Observational evidence suggests that never versus ever feeding human milk (limited evidence) and shorter versus longer durations of any (moderate evidence) and exclusive (limited evidence) human milk feeding are associated with higher type 1 diabetes risk. Insufficient evidence examined type 2 diabetes. Limited evidence suggests that the durations of any and exclusive human milk feeding are not associated with intermediate outcomes (e.g., fasting glucose, insulin resistance) during childhood.ConclusionsLimited to moderate evidence suggests that feeding less or no human milk is associated with higher risk of type 1 diabetes in offspring. Limited evidence suggests no associations between the durations of any and exclusive human milk feeding and intermediate diabetes outcomes in children. Additional research is needed on infant milk-feeding practices and type 2 diabetes and intermediate outcomes in US populations, which may have distinct metabolic risk.

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Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqy283 ◽

2019 ◽

Vol 109 (Supplement_1) ◽

pp. 772S-799S ◽

Cited By ~ 22

Author(s):

Darcy Güngör ◽

Perrine Nadaud ◽

Concetta C LaPergola ◽

Carol Dreibelbis ◽

Yat Ping Wong ◽

...

Keyword(s):

Systematic Review ◽

Allergic Rhinitis ◽

Atopic Dermatitis ◽

Human Milk ◽

Systematic Reviews ◽

Childhood Asthma ◽

Included Study ◽

Food Allergies ◽

Review Team ◽

Milk Feeding

ABSTRACT Background During the Pregnancy and Birth to 24 Months Project, the USDA and Department of Health and Human Services initiated a review of evidence on diet and health in these populations. Objectives The aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding prior to infant formula introduction, 4) feeding a lower versus higher intensity of human milk to mixed-fed infants, and 5) feeding a higher intensity of human milk by bottle versus breast with food allergies, allergic rhinitis, atopic dermatitis, and asthma. Methods The Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published between January 1980 and March 2016, dual-screened the results according to predetermined criteria, extracted data from and assessed the risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence. Results The systematic reviews numbered 1–5 above included 44, 35, 1, 0, and 0 articles, respectively. Moderate, mostly observational, evidence suggests that 1) never versus ever being fed human milk is associated with higher risk of childhood asthma, and 2) among children and adolescents who were fed human milk as infants, shorter versus longer durations of any human milk feeding are associated with higher risk of asthma. Limited evidence does not suggest associations between 1) never versus ever being fed human milk and atopic dermatitis in childhood or 2) the duration of any human milk feeding and allergic rhinitis and atopic dermatitis in childhood. Conclusions Moderate evidence suggests that feeding human milk for short durations or not at all is associated with higher childhood asthma risk. Evidence on food allergies, allergic rhinitis, and atopic dermatitis is limited.

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