scholarly journals Novel N-cyanoguanidyl derivatives: Synthesis and studying their toxicological activity against Spodoptera littoralis and Schizaphis graminum

2021 ◽  
Vol 10 (4) ◽  
pp. 363-370 ◽  
Author(s):  
A. Khodairy ◽  
Erian. S. Mansour ◽  
Omar M. Elhady ◽  
Ali M. Drar
Keyword(s):  
Spodoptera Littoralis ◽  
Schizaphis Graminum ◽  
Active Group ◽  
Acid Chlorides ◽  
Toxicological Activity

Reaction of N-cyanoguanidine with acid chlorides and aroylisothiocyanates gave the respective; N-(N-cyanocarbamimidoyl)aryl-2-carboxamides 1-5 and N-[(N-cyanocarbamimidoyl)carbamothioyl]benzamides 6-10, which have a Neonictinoid insecticide’s active group moiety (=N–CN). They have more toxicological activity against wheat Aphid (Schizaphis graminum) than Spodoptera littoralis.

scholarly journals Synthesis and characterization of some new tebufenozide analogues and study their toxicological effect against Spodoptera littoralis (Boisd.)

2022 ◽  
Vol 11 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Omar M. Elhady ◽  
Erian. S. Mansour ◽  
M. M. Elwassimy ◽  
Sameh A. Zawam ◽  
Ali M. Drar
Keyword(s):  
Spodoptera Littoralis ◽  
Chemical Change ◽  
Cotton Leaf ◽  
Aromatic Rings ◽  
Toxicological Study ◽  
Toxicological Effect ◽  
Tert Butyl ◽  
Toxicological Activity ◽  
Concentration Levels

Many of mimic analogues synthesized before depending on the change in the structure of aromatic rings. In this work, the carbonyl group in the structure of compounds 1-4 converted to thiocarbonyl group, and then studying the toxicological activity due to chemical change in the active center of mimic analogues was performed for compounds N-tert-butyl-2,4-dichloro-N'-(2,4-dichlorobenzoyl)benzohydrazide (2) and N-tert-butyl-2,4-dichloro-N'-[(2,4-dichlorophenyl)carbonothioyl]benzenecarbothiohydrazide (6). The toxicological study was done by using 2nd and 4th instar larvae of the cotton leaf worm, Spodoptera littoralis (Boisd.). Five concentration levels (600, 300, 150, 75 and 37.5 ppm) of compounds (2) and (6) were applied on the fresh plant food to the newly grown (2nd and 4th) instar larvae.

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