scholarly journals Targeting influenza at the Topologically conserved substructures

Author(s):  
Zubair Ahamed ◽  
Vandana Kamjula ◽  
Bhuvaneswari Kakunuri

H9N2 avian influenza virus is a low pathogenic endemic strain in the domestic poultry of most of the Asian countries. Attempts have extensively failed in eradicating its diverse strains. To find the drug against the evolutionarily conserved substructures, the target protein sequence is analyzed through sequence and modelled structure for mapping the structurally conserved topology. The available drugs are screened against the deciphered topological map through the predicted ADMET and drug-likelihood scores. This study helps to build a theoretical framework to make the foremost potent drug.

2020 ◽  
Author(s):  
Zubair Ahamed ◽  
Kamjula Vandana ◽  
Kakunuri Bhuvaneswari

ABSTRACTH9N2 avian influenza virus is a low pathogenic endemic strain in the domestic poultry of most of the Asian countries. Attempts have extensively failed in eradicating its diverse strains. To find the drug against the evolutionarily conserved substructures, the target protein sequence is analyzed through sequence and modelled structure for mapping the structurally conserved topology. The available drugs are screened against the deciphered topological map through the predicted ADMET and drug-likelihood scores. This study helps to build a theoretical framework to make the foremost potent drug.


Author(s):  
Wanwan Yan ◽  
Hongrui Cui ◽  
Marc Engelsma ◽  
Nancy Beerens ◽  
Monique M. van Oers ◽  
...  

The H9N2 low pathogenicity avian influenza (LPAI) virus has become endemic in poultry globally. In several Asian countries, vaccination against H9N2 avian influenza virus (AIV) was approved to reduce economic losses in the poultry industry.


AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Fei Wang ◽  
Yajuan Wang ◽  
Zhimin Wan ◽  
Hongxia Shao ◽  
Kun Qian ◽  
...  

2009 ◽  
Vol 138 (1-2) ◽  
pp. 85-91 ◽  
Author(s):  
Rui Wu ◽  
Hongbo Zhang ◽  
Keli Yang ◽  
Wangwang Liang ◽  
Zhongliang Xiong ◽  
...  

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