scholarly journals Molecular and Antigenic Characterization of Avian H9N2 Viruses in Southern China

2022 ◽  
Author(s):  
Wanwan Yan ◽  
Hongrui Cui ◽  
Marc Engelsma ◽  
Nancy Beerens ◽  
Monique M. van Oers ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Southern China ◽  
Economic Losses ◽  
Poultry Industry ◽  
Asian Countries ◽  
H9n2 Avian Influenza Virus ◽  
Antigenic Characterization

The H9N2 low pathogenicity avian influenza (LPAI) virus has become endemic in poultry globally. In several Asian countries, vaccination against H9N2 avian influenza virus (AIV) was approved to reduce economic losses in the poultry industry.

scholarly journals Characterization of the Whole-Genome Sequence of an H3N6 Avian Influenza Virus, Isolated from a Domestic Duck in Guangxi, Southern China

2015 ◽  
Vol 3 (5) ◽  
Author(s):  
Tingting Liu ◽  
Zhixun Xie ◽  
Sisi Luo ◽  
Liji Xie ◽  
Xianwen Deng ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Southern China ◽  
Scientific Evidence ◽  
Whole Genome Sequence ◽  
Domestic Duck ◽  
Guangxi Province ◽  
Eurasian Lineage

A field strain of H3N6 avian influenza virus (AIV), A/duck/Guangxi/175D12/2014(H3N6), was isolated from a native duck in Guangxi Province, southern China, in 2014. All of the eight AIV gene segments were sequenced, and sequence results revealed that there were 11 amino acid deletions at the NA stalk region. The NA, PB2, and NP genes showed highest homology to H5N6 AIV, and the PA gene showed highest homology to H7N2 AIV. Phylogenetic analysis indicated that the eight AIV gene segments belonged to the Eurasian lineage. These findings provide scientific evidence of possible or potential mutations of H3N6 AIV circulating in waterfowl in southern China.

scholarly journals Characterization of an Avian Influenza Virus H9N2 Strain Isolated from Dove in Southern China

2018 ◽  
Vol 6 (18) ◽  
pp. e00369-18 ◽  
Author(s):  
Dan Li ◽  
ZhengTing Li ◽  
Zhixun Xie ◽  
Meng Li ◽  
Zhiqin Xie ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Genome Sequence ◽  
Complete Genome Sequence ◽  
Complete Genome ◽  
Wild Bird ◽  
Southern China

ABSTRACT We report here the complete genome sequence of strain H9N2, an avian influenza virus (AIV) isolated from dove in Guangxi, China. Phylogenetic analysis showed that it was a novel reassortant AIV derived from chicken, duck, and wild bird. This finding provides useful information for understanding the H9N2 subtype of AIV circulating in southern China.

scholarly journals Genome Sequence of an H9N2 Avian Influenza Virus Strain with Hemagglutinin-Neuraminidase Combination, Isolated from a Quail in Guangxi, Southern China

2017 ◽  
Vol 5 (38) ◽  
Author(s):  
Liji Xie ◽  
Zhixun Xie ◽  
Dan Li ◽  
Sisi Luo ◽  
Minxiu Zhang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Southern China ◽  
Molecular Characteristics ◽  
Typical Characteristic ◽  
Amino Acid Motif ◽  
H9n2 Avian Influenza Virus ◽  
Pathogenic Avian Influenza ◽  
Pathogenic Avian Influenza Virus

ABSTRACT We isolated a strain of H9N2 avian influenza virus from a quail in southern China in May 2015 and named it A/quail/Guangxi/198Q39/2015. All eight gene segments of the strain were sequenced. Sequence analysis indicated that the amino acid motif of the hemagglutinin cleavage site of this H9N2 virus was RSSR↓GLF, which is a typical characteristic of the low pathogenic avian influenza virus. This study will help in better understanding the epidemiology and molecular characteristics of avian influenza virus in wild birds.

scholarly journals Generation and Evaluation of Recombinant Thermostable Newcastle Disease Virus Expressing the HA of H9N2 Avian Influenza Virus

Viruses ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1606
Author(s):  
Xiaorong Zhang ◽  
Zongyi Bo ◽  
Chenchen Meng ◽  
Yin Chen ◽  
Chengcheng Zhang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Newcastle Disease Virus ◽  
Avian Influenza Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Transmembrane Domain ◽  
Economic Losses ◽  
Tail Domain ◽  
H9n2 Avian Influenza Virus

H9N2 avian influenza virus (AIV) has become endemic in many countries, causing great economic losses when co-infected with other pathogens. So far, several live vaccines based on Newcastle disease virus (NDV) vectors expressing influenza hemagglutinin (HA) have been developed. However, the thermostable recombinant NDV is rarely reported. In this study, using a thermostable NDV rAHR09 strain as the vector, three recombinant NDVs expressing native HA, chimeric HA ectodomain with transmembrane domain/C-terminal cytoplasmic tail domain from fusion protein of NDV, and HA ectodomain were generated, designated rAHR09-HA, rAHR09-HAF, and rAHR09-HAE. The MDT value of three recombinant NDVs was above 120 h, their ICPI value was about 0.03, and the recombinant NDVs were still infectious when treated for 100 min under 56 °C, which demonstrated that the recombinant NDVs kept the lentogenic and thermostable nature of rAHR09. The immunization data showed that rAHR09-HA and rAHR09-HAF induced a higher HI antibody titer against H9N2 AIV and NDV. After being challenged with H9N2 AIV, the rAHR09-HA and rAHR09-HAF could significantly reduce the virus shedding in cloacal and tracheal swab samples. Our results suggest that rAHR09-HA and rAHR09-HAF might be vaccine candidates against H9N2 AIV.

scholarly journals Antigenic Characterization of Recombinant Hemagglutinin Proteins Derived from Different Avian Influenza Virus Subtypes

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9097 ◽  
Author(s):  
Matthias Mueller ◽  
Sandra Renzullo ◽  
Roxann Brooks ◽  
Nicolas Ruggli ◽  
Martin A. Hofmann
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Antigenic Characterization ◽  
Recombinant Hemagglutinin

Genetic characterization of H9N2 avian influenza virus in plateau pikas in the Qinghai Lake region of China

2016 ◽  
Vol 162 (4) ◽  
pp. 1025-1029 ◽  
Author(s):  
Yan Yan ◽  
Jin-Yan Gu ◽  
Zhuang-Chuan Yuan ◽  
Xin-Yu Chen ◽  
Zeng-Kui Li ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Genetic Characterization ◽  
Qinghai Lake ◽  
H9n2 Avian Influenza Virus ◽  
Lake Region

scholarly journals Characterization of an H9N2 avian influenza virus from a Fringilla montifringilla brambling in northern China

Virology ◽  
2015 ◽  
Vol 476 ◽  
pp. 289-297 ◽  
Author(s):  
Jing Yuan ◽  
Lili Xu ◽  
Linlin Bao ◽  
Yanfeng Yao ◽  
Wei Deng ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Northern China ◽  
H9n2 Avian Influenza Virus

scholarly journals Targeting influenza at the Topologically conserved substructures

2021 ◽  
pp. 121-129
Author(s):  
Zubair Ahamed ◽  
Vandana Kamjula ◽  
Bhuvaneswari Kakunuri
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Protein Sequence ◽  
Asian Countries ◽  
Topological Map ◽  
H9n2 Avian Influenza Virus ◽  
Evolutionarily Conserved ◽  
Potent Drug ◽  
Endemic Strain

H9N2 avian influenza virus is a low pathogenic endemic strain in the domestic poultry of most of the Asian countries. Attempts have extensively failed in eradicating its diverse strains. To find the drug against the evolutionarily conserved substructures, the target protein sequence is analyzed through sequence and modelled structure for mapping the structurally conserved topology. The available drugs are screened against the deciphered topological map through the predicted ADMET and drug-likelihood scores. This study helps to build a theoretical framework to make the foremost potent drug.

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