scholarly journals The Effects Of Stem Cells On The Recovery Of Rotator Cuff Injuries

2021 ◽  
Vol 2 (2) ◽  
pp. 1-10
Author(s):  
Keeghan Andrews ◽  
Vincent S. Gallicchio
Keyword(s):  
Stem Cells ◽  
Rotator Cuff ◽  
Rotator Cuff Injuries

Stem Cells in Rotator Cuff Injuries and Reconstructions: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 14 (8) ◽  
pp. 683-697 ◽  
Author(s):  
Fanxiao Liu ◽  
Qingqi Meng ◽  
Heyong Yin ◽  
Zexing Yan
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Stem Cell ◽  
Rotator Cuff ◽  
Meta Analysis ◽  
Walking Distance ◽  
Cochrane Library ◽  
Cell Group ◽  
Control Group ◽  
Rotator Cuff Injuries

Background:Multiple studies have focused on stem cell-based treatments for rotator cuff disorders; however, the outcomes are not consistent.Objective:This systematic review and meta-analysis were performed to evaluate the effects of stem cells on rotator cuff healing.Methods:A detailed search of relevant studies was conducted in three databases including Pubmed/ Medline, Cochrane library, and Embase databases, using the following keywords: “rotator cuff” or “Tissue Engineering” AND “stem cell” from inception to January 01, 2019. The standard mean difference (SMD) and 95% confidence interval (CI) for each individual study were extracted from the original studies or calculated based on relevant data and pooled to obtain integrated estimates using random effects modeling.Results:A total of 22 studies were identified. The results demonstrated that the ultimate strain in the stem cell group was significantly higher than that in the control group at 4 and 8 weeks. Muscle weight in the stem cell group was higher than the control group at 8 weeks, while no significant differences were detected at 16 weeks. The stem cell group had lower visual analog scale scores (VAS) at 1, 3, and 6 months, and higher American shoulder and elbow surgeons score (ASES) at 3 months. In addition, the walking distance, time, and speed in the stem cell group were significantly superior to those in the control group.Conclusion:This meta-analysis confirms that stem cells improved the rehabilitation of rotator cuff disorders. However, larger-scale studies are needed to further support these findings.

scholarly journals Regenerative Medicine in Rotator Cuff Injuries

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Pietro Randelli ◽  
Filippo Randelli ◽  
Vincenza Ragone ◽  
Alessandra Menon ◽  
Riccardo D’Ambrosi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Growth Factors ◽  
Rotator Cuff ◽  
Platelet Rich Plasma ◽  
Biceps Tendon ◽  
Tendon Healing ◽  
Rotator Cuff Tears ◽  
Common Source ◽  
Rotator Cuff Injuries

Rotator cuff injuries are a common source of shoulder pathology and result in an important decrease in quality of patient life. Given the frequency of these injuries, as well as the relatively poor result of surgical intervention, it is not surprising that new and innovative strategies like tissue engineering have become more appealing. Tissue-engineering strategies involve the use of cells and/or bioactive factors to promote tendon regeneration via natural processes. The ability of numerous growth factors to affect tendon healing has been extensively analyzedin vitroand in animal models, showing promising results. Platelet-rich plasma (PRP) is a whole blood fraction which contains several growth factors. Controlled clinical studies using different autologous PRP formulations have provided controversial results. However, favourable structural healing rates have been observed for surgical repair of small and medium rotator cuff tears. Cell-based approaches have also been suggested to enhance tendon healing. Bone marrow is a well known source of mesenchymal stem cells (MSCs). Recently,ex vivohuman studies have isolated and cultured distinct populations of MSCs from rotator cuff tendons, long head of the biceps tendon, subacromial bursa, and glenohumeral synovia. Stem cells therapies represent a novel frontier in the management of rotator cuff disease that required further basic and clinical research.

Serious Rotator Cuff Injuries

1983 ◽  
Vol 2 (2) ◽  
pp. 407-412 ◽  
Author(s):  
Frank W. Jobe
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Injuries

Rotator cuff injuries in adolescent athletes

2013 ◽  
Vol 22 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Jennifer M. Weiss ◽  
Alexandre Arkader ◽  
Lawrence M. Wells ◽  
Theodore J. Ganley
Keyword(s):  
Rotator Cuff ◽  
Adolescent Athletes ◽  
Rotator Cuff Injuries

The Regenerative Role of Gelatin in PLLA Electrospun Membranes for the Treatment of Chronic Massive Rotator Cuff Injuries

2021 ◽  
pp. 2100281
Author(s):  
Chang Liu ◽  
Shihai Jiang ◽  
Yu Wu ◽  
Libiao Liu ◽  
Shouwen Su ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Injuries ◽  
Electrospun Membranes

The effect of adipose-derived stem cells on enthesis healing after repair of acute and chronic massive rotator cuff tears in rats

2019 ◽  
Vol 28 (4) ◽  
pp. 654-664 ◽  
Author(s):  
Benjamin B. Rothrauff ◽  
Catherine A. Smith ◽  
Gerald A. Ferrer ◽  
João V. Novaretti ◽  
Thierry Pauyo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Rotator Cuff ◽  
Rotator Cuff Tears ◽  
Adipose Derived Stem Cells ◽  
Massive Rotator Cuff Tears

Rotator cuff injuries

2018 ◽  
Vol 31 (4) ◽  
pp. 49-50
Author(s):  
Nicole Bartoszewski ◽  
Nata Parnes
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Injuries
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