scholarly journals CH50 Activity and its Relationship to Antimüllerian Hormone in Patients with Infertility

2021 ◽  
Vol 1 (3) ◽  
Author(s):  
José Manuel Lozano Sánchez
Keyword(s):  
Ovarian Reserve ◽  
Spearman Correlation ◽  
Complement Pathway ◽  
Cross Sectional ◽  
Vitro Fertilization ◽  
Tertiary Referral Center ◽  
Antimullerian Hormone ◽  
Age Related ◽  
Antimüllerian Hormone

Objective: To study the importance of immunological screening (CH50, C3, C4) to determine the correlation between the ovarian reserve and complement pathway. Design: A cross-sectional multivariate study. Setting: Single tertiary referral center. Patients: 40 Women with infertility diagnosis who underwent In Vitro Fertilization (IVF). Intervention(s): Basal blood samples collected to measure complement pathway and antimüllerian hormone. Main Outcome Measure(s): To correlate complement pathways (CH50 levels) with AMH. Results: The complement system and ovarian reserve were studied in 40 women aged from 28-48 years (mean=37.87 years), finding the values of CH50 65-268 CAE (mean=153.2 CAE), C3 13.9- 183mg/dl (mean=128.52mg/dl), C4 11.5-106mg/dl (mean=29.86mg/dl), AMH 0.10-3.9ng/dl (mean=1.32ng/dl). A multivariate analysis comparison was also conducted yielding significant results: negative correlation between AMH and age (Spearman correlation -0.6; P=0.001), as well as between AMH and CH50 (Spearman correlation -0.4; P=0.0129). Conclusion: High CH50 levels are correlated with an AMH decrease and it could be accordingly associated with age-related chronic inflammation. Capsule: High levels of CH50 are correlated with a decrease in AMH levels and could also be considered as a marker of poor response in IVF cycles.

Australians' understanding of the decline in fertility with increasing age and attitudes towards ovarian reserve screening

2018 ◽  
Vol 24 (5) ◽  
pp. 428
Author(s):  
Alisha Evans ◽  
Sheryl de Lacey ◽  
Kelton Tremellen
Keyword(s):  
Ovarian Reserve ◽  
Online Survey ◽  
Parental Leave ◽  
Vitro Fertilization ◽  
Life Planning ◽  
Age Related ◽  
Increased Risk ◽  
Reproductive Life ◽  
Natural Conception

The aim of this study is to determine Australians’ understanding of the decline in fertility with age, social determinants that influence their decision to start a family and attitudes towards ovarian reserve screening as a tool allowing personalised reproductive life planning. An online survey of 383 childless Australian men and women, aged 18–45 years, was conducted. Both sexes overestimated natural and in vitro fertilization (IVF)-assisted fertility potential with increasing age, with the magnitude of overestimation being more pronounced for men and IVF treatment compared with natural conception. The primary determinants for starting a family were a stable relationship, followed by establishment of career; availability of accessible child care and paid parental leave were considered less important. Finally, the majority of women (74%) would alter their reproductive life planning if they were identified as having low ovarian reserve on screening. Despite increased education, Australians continue to have a poor understanding of age-related decline in natural and IVF-assisted conception, potentially explaining why many delay starting a family. Ovarian reserve screening may help identify individuals at increased risk of premature diminished fertility, giving these women the ability to bring forward their plans for natural conception or undertake fertility preservation (oocyte freezing).

Serum antimüllerian hormone is not predictive of oocyte quality in vitro fertilization

2009 ◽  
Vol 70 (4) ◽  
pp. 230-234 ◽  
Author(s):  
F. Guerif ◽  
M. Lemseffer ◽  
M.-L. Couet ◽  
O. Gervereau ◽  
V. Ract ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Oocyte Quality ◽  
Vitro Fertilization ◽  
Antimullerian Hormone ◽  
Antimüllerian Hormone

Corrigendum to: Australians' understanding of the decline in fertility with increasing age and attitudes towards ovarian reserve screening

2019 ◽  
Vol 25 (1) ◽  
pp. 97
Author(s):  
Alisha Evans ◽  
Sheryl de Lacey ◽  
Kelton Tremellen
Keyword(s):  
Ovarian Reserve ◽  
Online Survey ◽  
Parental Leave ◽  
Vitro Fertilization ◽  
Life Planning ◽  
Age Related ◽  
Increased Risk ◽  
Reproductive Life ◽  
Natural Conception

The aim of this study is to determine Australians’ understanding of the decline in fertility with age, social determinants that influence their decision to start a family and attitudes towards ovarian reserve screening as a tool allowing personalised reproductive life planning. An online survey of 383 childless Australian men and women, aged 18–45 years, was conducted. Both sexes overestimated natural and in vitro fertilization (IVF)-assisted fertility potential with increasing age, with the magnitude of overestimation being more pronounced for men and IVF treatment compared with natural conception. The primary determinants for starting a family were a stable relationship, followed by establishment of career; availability of accessible child care and paid parental leave were considered less important. Finally, the majority of women (74%) would alter their reproductive life planning if they were identified as having low ovarian reserve on screening. Despite increased education, Australians continue to have a poor understanding of age-related decline in natural and IVF-assisted conception, potentially explaining why many delay starting a family. Ovarian reserve screening may help identify individuals at increased risk of premature diminished fertility, giving these women the ability to bring forward their plans for natural conception or undertake fertility preservation (oocyte freezing).

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