Diffuse Cutaneous Metastases as the Only Sign of Extranodal Tumor Spread in a Patient with Adenocarcinoma of the Colon

Cutaneous metastases from large bowel cancer are uncommon and are usually associated with organ involvement. Localization of lesions to the skin is mainly attributed to vascular and anatomical relationship, since most of them are seen in the abdominal wall or in a surgical scar. We report a 73-year-old woman in whom metastatic nodules from a poorly differentiated adenocarcinoma of the right colon developed throughout the skin (buttock, trunk, chest wall, arms, and neck) and remained the only sign of extranodal tumor spread until patient's death, seven months later. This unusual behaviour suggests that localization of neoplastic cells to the skin may be a site-specific process, determined by adhesion molecules and/or by growth factors found at that site.

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METASTASIS OF AN ADENOCARCINOMA OF THE STOMACH TO THE 4TH METACARPAL BONE

Hand Surgery ◽

10.1142/s0218810401000515 ◽

2001 ◽

Vol 06 (02) ◽

pp. 239-242 ◽

Cited By ~ 6

Author(s):

H. C. Chang ◽

K. H. Lew ◽

C. O. Low

Keyword(s):

Metastatic Lesion ◽

Metacarpal Bone ◽

Review Of The Literature ◽

Poorly Differentiated Adenocarcinoma ◽

Poorly Differentiated ◽

The Right

Metastatic tumours of the hand are uncommon. The majority of these tumours affect the phalanges and the primary tumours are usually bronchogenic in origin, with breast and kidney tumours next in frequency. Metastatic gastrointestinal to the hand is rare and usually from the colon. We report a case of poorly differentiated adenocarcinoma of the stomach antrum presenting with a metastatic lesion to the right 4th metacarpal bone. A review of the literature is included.

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Medullary Carcinoma of the Gastrointestinal Tract: Report on Two Cases with Immunohistochemical and Molecular Features

Diagnostics ◽

10.3390/diagnostics11101775 ◽

2021 ◽

Vol 11 (10) ◽

pp. 1775

Author(s):

Cristina Colarossi ◽

Marzia Mare ◽

Giorgio La Greca ◽

Marco De Zuanni ◽

Lorenzo Colarossi ◽

...

Keyword(s):

Older Women ◽

Specific Treatment ◽

Medullary Carcinoma ◽

Good Prognosis ◽

Right Colon ◽

Carcinoma Of The Colon ◽

Molecular Features ◽

Histological Variant ◽

Poorly Differentiated ◽

The Right

Medullary carcinoma of the colon is a rare histological variant characterized by a poorly differentiated morphology, an aberrant immunophenotype, and microsatellite instability. Despite the lack of glandular differentiation, medullary carcinoma is reported to have a good prognosis. It is typically located in the right colon and frequently affects older women. Due to its clinical, histological, biological, and genetic peculiarity, medullary carcinoma requires an accurate diagnosis and the awareness of this diagnostic possibility. We describe the morphological, immunohistochemical, and molecular findings of two interesting cases, the first one in the right colon of a patient and the second one in the terminal ileum of a patient with Crohn’s disease. Deeper knowledge of all the biological and clinical features will allow appropriate and specific treatment of this tumor in the future.

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Poorly differentiated adenocarcinoma of the colon: subsite location and clinicopathologic features

International Journal of Colorectal Disease ◽

10.1007/s00384-014-2070-0 ◽

2014 ◽

Vol 30 (2) ◽

pp. 187-196 ◽

Cited By ~ 4

Author(s):

Yasuo Imai

Keyword(s):

Clinicopathologic Features ◽

Poorly Differentiated Adenocarcinoma ◽

Poorly Differentiated ◽

Adenocarcinoma Of The Colon

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Clinicopathological Study on Poorly Differentiated Adenocarcinoma of the Colon

The Kurume Medical Journal ◽

10.2739/kurumemedj.58.41 ◽

2011 ◽

Vol 58 (2) ◽

pp. 41-46 ◽

Cited By ~ 7

Author(s):

TAKEFUMI YOSHIDA ◽

YOSHITO AKAGI ◽

TETSUSHI KINUGASA ◽

ICHITARO SHIRATSUCHI ◽

YASUHIKO RYU ◽

...

Keyword(s):

Poorly Differentiated Adenocarcinoma ◽

Clinicopathological Study ◽

Poorly Differentiated ◽

Adenocarcinoma Of The Colon

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CLINICOPATHOLOGICAL FEATURES OF POORLY DIFFERENTIATED ADENOCARCINOMA OF THE COLON AND RECTUM

The journal of the Japanese Practical Surgeon Society ◽

10.3919/ringe1963.53.313 ◽

1992 ◽

Vol 53 (2) ◽

pp. 313-317

Author(s):

Sengai TANAKA ◽

Hiroo OSHITA ◽

Daizo FUKATA

Keyword(s):

Clinicopathological Features ◽

Poorly Differentiated Adenocarcinoma ◽

Colon And Rectum ◽

Poorly Differentiated ◽

Adenocarcinoma Of The Colon

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Dome-Type: A Distinctive Variant of Colonic Adenocarcinoma

Case Reports in Pathology ◽

10.1155/2012/284064 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 3

Author(s):

Giacomo Puppa ◽

Mariella Molaro

Keyword(s):

Mismatch Repair ◽

Lymphoid Tissue ◽

Histopathological Examination ◽

Low Risk ◽

Colonic Adenocarcinoma ◽

Right Colon ◽

Early Lesions ◽

Adenocarcinoma Of The Colon ◽

The Right ◽

Distinguishing Features

Introduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features.Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old man. Histopathological examination showed a cancerized adenoma invading the submucosa with several typical features of dome-type adenocarcinoma, in particular the associated prominent lymphoid tissue. Immunohistochemistry showed retention of the mismatch repair proteins MLH-1, MSH-2, MLH-6, and PMS-2.Conclusion. We report an additional case of dome-type adenocarcinoma of the colon as an early, low-risk, and microsatellite stable tumor, indicating that this particular histotype may deserve specific consideration for both classification and management.

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Oral Floor and Gingival Metastasis of Cholangiocarcinoma: A Case Report and Review of the Literature

Case Reports in Pathology ◽

10.1155/2014/712912 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3

Author(s):

Yukihiro Nakanishi ◽

Bo Xu ◽

Charles LeVea

Keyword(s):

Oral Cavity ◽

Pulmonary Nodules ◽

Unusual Site ◽

Poorly Differentiated Adenocarcinoma ◽

Gingival Metastasis ◽

Poorly Differentiated ◽

Right Lobe ◽

Gingival Mucosa ◽

The Right ◽

Caucasian Female

The oral cavity is very unusual site of metastases even though wide spread metastatic disease may be present. The most common primary sites that metastasize to the oral cavity are lung, kidney, breast, and hepatocellular carcinoma. We present a rare case of a 77-year-old Caucasian female with metastasis from a cholangiocarcinoma to the oral floor contiguous with lingual gingival mucosa. The patient presented with left sided rib pain. A CT scan of the chest, abdomen, and pelvis showed multiple pulmonary nodules and a single dominant mass in the right lobe of the liver. This tumor was 6.5 cm with multiple satellite lesions surrounding it. The liver biopsy was diagnostic of a moderately to poorly differentiated adenocarcinoma, consistent with a primary cholangiocarcinoma. After undergoing one cycle of gemcitabine chemotherapy, the patient noticed an extremely rapidly growing mass involving her right lower gingiva and the entire right floor of her mouth. The biopsy of that mass also showed a moderately to poorly differentiated adenocarcinoma. The gingival tumor had a similar cytomorphology and immunophenotype as her cholangiocarcinoma. Therefore, an unusual site for metastatic cholangiocarcinoma was confirmed.

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A 48-Year-Old Male with Cutaneous Metastases of NUT Midline Carcinoma Misdiagnosed as Herpes Zoster

Case Reports in Oncology ◽

10.1159/000481429 ◽

2017 ◽

Vol 10 (3) ◽

pp. 987-991 ◽

Cited By ~ 2

Author(s):

Lauren N. Ko ◽

Qing Y. Weng ◽

Johanna S. Song ◽

Mackenzie Asel ◽

Scott R. Granter ◽

...

Keyword(s):

Herpes Zoster ◽

Nuclear Protein ◽

Skin Involvement ◽

Cutaneous Metastases ◽

Nut Midline Carcinoma ◽

Dismal Prognosis ◽

Poorly Differentiated ◽

Nut Carcinoma ◽

The Right ◽

Time Of Presentation

NUT (nuclear protein of the testis) midline carcinoma (NMC) is a rare, poorly differentiated neoplasm with dismal prognosis. Though NMC are often metastatic by the time of presentation, cutaneous metastases have not been well described in the literature. We report a case of NMC in a patient who presented with grouped well-demarcated tender non-ulcerated erythematous nodules on the right mid-back. The lesions were initially diagnosed and treated as herpes zoster. Following failure to improve with antiviral therapy, imaging and skin biopsy revealed that the lesions were in fact cutaneous NUT carcinoma. Although NMC is an uncommon diagnosis, clinicians should be aware that affected patients can develop skin involvement to avoid unnecessary and harmful treatments.

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