scholarly journals Sicker Patients for Liver Transplantation: Meld, Meld Sodium, and Integrated Meld’s Prognostic Accuracy in the Assessment of Posttransplantation Events at a Single Center from Argentina

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Federico Piñero ◽  
Sebastián Marciano ◽  
Alejandra Villamil ◽  
Juan Bandi ◽  
Paola Casciato ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Liver Transplantation ◽  
Patient Survival ◽  
Ventilatory Support ◽  
Single Center ◽  
Short Term ◽  
Mechanical Ventilatory Support ◽  
Prognostic Accuracy ◽  
Intensive Care Stay ◽  
Cirrhotic Patients

Background. MELD or MELD sodium promotes sicker patients for earlier liver transplantation (LT); the balance between pre- and post-LT outcomes is still controversial. Aim. To compare MELD and related scores’ risk assessment of short-term morbidity and mortality after LT. Methods. We included only transplanted cirrhotic patients from 6/2005 to 6/2010 (). Immediate pre-LT MELD, integrated MELD (iMELD), and two MELD sodium formulas “MELD Na1” and “MELDNa2” were calculated. Results. Pre-LT scores for nonsurvivors were higher than those for survivors: MELD (28 ± 8 versus 22 ± 7, ), MELD Na1 (33 ± 8 versus 27 ± 10, ), and iMELD (51 ± 6 versus 46 ± 8, ). Patient survival assessment was performed by AUROC analysis (95% CI): MELD 0.694 (0.56–0.82; ), MELD Na1 0.682 (0.56–0.79; ), MELD Na2 0.651 (0.54–0.76; ), and iMELD 0.698 (0.593–0.80; ). Patients with MELD ≥25 points had longer intensive care stay (mean 10 versus 7 days, ) and longer mechanical ventilatory support (5.4 versus 1.9 days, ). Conclusions. The addition of serum sodium to MELD does not improve assessment of mortality after LT. Patients with higher MELD may preclude higher morbidity after transplantation.

F.N.48 INFLUENCE OF DONOR–RECIPIENT VARIABLES ON SHORT TERM PATIENT SURVIVAL FOLLOWING LIVER TRANSPLANTATION (LT)

2010 ◽  
Vol 42 ◽  
pp. S50-S51
Author(s):  
M. Gambato ◽  
M. Senzolo ◽  
T. De Feo ◽  
F.P. Russo ◽  
G. Germani ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Patient Survival ◽  
Short Term

MELD scores with incorporation of serum sodium and death prediction in cirrhotic patients on the waiting list for liver transplantation: a single center experience in southern Brazil

2012 ◽  
Vol 26 (4) ◽  
pp. E395-E401 ◽  
Author(s):  
Caroline Possa Marroni ◽  
Ajácio Bandeira de Mello Brandão ◽  
Alexandre Wahl Hennigen ◽  
Claudio Marroni ◽  
Maria Lúcia Zanotelli ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Serum Sodium ◽  
Waiting List ◽  
Southern Brazil ◽  
Single Center ◽  
Single Center Experience ◽  
Cirrhotic Patients

scholarly journals Single-Slice Analytic Morphomics Compared to SRTR Risk Assessment, a Single-Center Pilot Study in Liver Transplantation

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
BS Ali M. Hammoud ◽  
BS Chris S. Lee ◽  
MS Brian A. Derstine ◽  
MS Jeffrey F. Friedman ◽  
DO Dane R. Grenda ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Liver Transplantation ◽  
Pilot Study ◽  
Single Center ◽  
Single Slice

Liver transplantation for hepatocellular carcinoma in cirrhotic patients—a single-center experience

2003 ◽  
Vol 35 (1) ◽  
pp. 379-380 ◽  
Author(s):  
A.K.K Chui ◽  
A.R.N Rao ◽  
J Wong ◽  
S.S.M Ng ◽  
H.L.Y Chan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Single Center ◽  
Single Center Experience ◽  
Cirrhotic Patients

P.159 INFLUENCE OF DONOR—RECIPIENT VARIABLES ON SHORT TERM PATIENT SURVIVAL FOLLOWING LIVER TRANSPLANTATION (LT)

2010 ◽  
Vol 42 ◽  
pp. S159
Author(s):  
M. Gambato ◽  
M. Senzolo ◽  
T. De Feo ◽  
F.P. Russo ◽  
G. Germani ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Patient Survival ◽  
Short Term

scholarly journals A207 DE NOVO DONOR-SPECIFIC ANTIBODY FORMATION IN LIVER TRANSPLANTS: RISK FACTORS FOR DEVELOPMENT AND IMPACT ON GRAFT SURVIVAL.

2021 ◽  
Vol 4 (Supplement_1) ◽  
pp. 236-237
Author(s):  
C Wang ◽  
A J Montano-Loza ◽  
P M Campbell ◽  
V Bain
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Liver Disease ◽  
Organ Transplantation ◽  
Graft Survival ◽  
Patient Survival ◽  
De Novo ◽  
Single Center ◽  
Liver Transplants ◽  
Post Transplant

Abstract Background Antibody mediated rejection (AMR) is an area of great importance in solid organ transplantation. Donor-specific antibodies (DSA) have emerged as relevant biomarkers in predicting graft function and survival. DSA detected post-transplant may either be preformed or de novo and emerging evidence suggests de novo DSA, in particular, is associated with inferior graft outcomes. In contrast to the clear role that AMR plays in renal and thoracic organ transplantation, its importance in liver transplants remains controversial. Aims The aim of this study was to determine the risk factors associated with de novo DSA formation and to evaluate its role in determining clinical outcomes after liver transplantation. Methods This single-center retrospective study compiled data on liver transplants performed between 2005 and 2019 in Edmonton, Canada. Data collected from medical charts included gender, age at transplant, reason for transplant, and immunosuppressive regimens, among several others. The presence of DSA was determined by single antigen flow beads until 2009 and by Luminex thereafter. Potential predictors of DSA formation were evaluated using Cox proportional hazard models. Graft survival estimates were obtained using the Kaplan-Meier method and comparisons between patient groups were conducted using the log-rank test. Results Between 2005–2019, 131 patients had measurements of DSA both before and after liver transplantation. In this cohort, 17 patients (13%) tested negative on DSA screening before transplant but developed new antibodies against either Class I or Class II molecules post-transplant. Risk factor analysis revealed transplants performed in the setting of autoimmune liver disease (PSC, PBC, and autoimmune hepatitis) had higher risks of developing de novo DSA post-transplant (p=0.002. See Table 1). Graft survival probability at 5- and 10-years was 72% and 61% in those with de novo DSA formation, compared to 93% and 89% in patients without de novo DSA formation (p=0.04. See Figure 1). Overall patient survival was similar between the two groups. Conclusions In this single-center study, a transplant done in the setting of autoimmune liver disease had a higher risk of de novo DSA formation. Furthermore, de novo DSA formation lead to a decreased graft survival time in liver transplant patients but overall patient survival was not significantly decreased. A standard approach to DSA monitoring, especially in high risk populations, is required to better understand its prevalence and impact in liver transplantation. Funding Agencies None

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