short term effect
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Author(s):  
Yuxia Ma ◽  
Jiahui Shen ◽  
Yifan Zhang ◽  
Hang Wang ◽  
Heping Li ◽  
...  




Author(s):  
Divyashikha Sethia ◽  
Taksh Kamlesh ◽  
Mrigank Singh ◽  
Sonia Baloni Ray




2021 ◽  
pp. 126538
Author(s):  
Anlong Zhang ◽  
Chuyue Gao ◽  
Tiantian Chen ◽  
Yili Xie ◽  
Xianbao Wang


Life ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1276
Author(s):  
K. Barbara Sahlin ◽  
Indira Pla ◽  
Jéssica de Siqueira Guedes ◽  
Krzysztof Pawłowski ◽  
Roger Appelqvist ◽  
...  

Long term effect of testosterone (T) deficiency impairs metabolism and is associated with muscle degradation and metabolic disease. The association seems to have a bidirectional nature and is not well understood. The present study aims to investigate the early and unidirectional metabolic effect of induced T changes by measuring fasting amino acid (AA) levels in a human model, in which short-term T alterations were induced. We designed a human model of 30 healthy young males with pharmacologically induced T changes, which resulted in three time points for blood collection: (A) baseline, (B) low T (3 weeks post administration of gonadotropin releasing hormone antagonist) and (C) restored T (2 weeks after injection of T undecanoate). The influence of T on AAs was analyzed by spectrophotometry on plasma samples. Levels of 9 out of 23 AAs, of which 7 were essential AAs, were significantly increased at low T and are restored upon T supplementation. Levels of tyrosine and phenylalanine were most strongly associated to T changes. Short-term effect of T changes suggests an increased protein breakdown that is restored upon T supplementation. Fasting AA levels are able to monitor the early metabolic changes induced by the T fluctuations.



2021 ◽  
pp. 108496
Author(s):  
Robert W. Brown ◽  
David R. Chadwick ◽  
Harriet Thornton ◽  
Miles R. Marshall ◽  
Shuikuan Bei ◽  
...  


2021 ◽  
Vol 156 ◽  
pp. 106614
Author(s):  
Florence Gignac ◽  
Jose Barrera-Gómez ◽  
Cecilia Persavento ◽  
Caterina Solé ◽  
Èlia Tena ◽  
...  


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