scholarly journals p16-negative warty carcinoma of the uterine cervix with superficial invasion to the endometrium: A case report focusing on diagnostic pitfalls

2017 ◽  
Vol 4 (3) ◽  
pp. 12
Author(s):  
Hyun-Jung Kim ◽  
Chul Min Lee
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Uterine Cervix ◽  
Low Risk ◽  
Proliferation Index ◽  
Invasive Squamous Cell Carcinoma ◽  
Ki 67 ◽  
Hpv Dna ◽  
Diagnostic Pitfalls

Warty carcinoma of the uterine cervix is a very rare and specific variant of invasive squamous cell carcinoma, usually described as a hybrid of the features of both condyloma acuminatum and invasive squamous cell carcinoma. The diagnostic pitfalls of this lesion are: 1) the bland appearance of cytomorphology, 2) distinct koilocytotic atypia, and 3) p16 negativity. A case of warty carcinoma with a fungating mass on the uterine cervix of a 75-year-old woman is presented. The original diagnosis by punch biopsy was atypical squamous cells, undetermined for malignancy, adjunct with p16 negativity. The subsequent radical hysterectomy showed a protruding mass (5.7 cm in horizontal dimension) of the uterine cervix. Light microscopy revealed a protruding mass composed of exophytic papillae and inverted nests along the endocervical glands. There were multiple micro-invasive foci (< 1 mm) of tongue like projections at the nest base and slight involvement of the upper vagina and endometrial surface. The p16 immunohistochemical staining yielded negative results. The results of the HPV DNA chip test from paraffin-embedded tissue were 6 (low risk, +++) and 42 (low risk, +). The Ki-67 proliferation index was approximately 20%. The invasive foci and patient’s age were the determining differential factors for malignancy rather than benign condylomatous lesion.

Intralesional 5-Fluorouracil for the Nonsurgical Management of Low-Risk, Invasive Squamous Cell Carcinoma

2020 ◽  
Vol 46 (1) ◽  
pp. 126-130 ◽  
Author(s):  
Emily E. Dando ◽  
Geoffrey F.S. Lim ◽  
Scott J.M. Lim ◽  
ChangHyun Kim ◽  
Melissa Pugliano-Mauro
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Low Risk ◽  
Invasive Squamous Cell Carcinoma ◽  
Nonsurgical Management

scholarly journals Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer

2015 ◽  
Vol 49 (3) ◽  
pp. 250-255 ◽  
Author(s):  
Adem Karaman ◽  
Irmak Durur-Subasi ◽  
Fatih Alper ◽  
Omer Araz ◽  
Mahmut Subasi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Negative Correlation ◽  
Small Cell ◽  
Proliferation Index ◽  
Tissue Sampling ◽  
Small Cell Lung ◽  
Ki 67 ◽  
The Mean

Abstract Background. The primary objective of the study was to evaluate the association between the minimum apparent diffusion coefficient (ADCmin) and Ki-67, an index for cellular proliferation, in non-small cell lung cancers. Also, we aimed to assess whether ADCmin values differ between tumour subtypes and tissue sampling method. Methods. The patients who had diffusion weighted magnetic resonance imaging (DW-MRI) were enrolled retrospectively. The correlation between ADCmin and the Ki-67 index was evaluated. Results. Ninety three patients, with a mean age 65 ± 11 years, with histopathologically proven adenocarcinoma and squamous cell carcinoma of the lungs and had technically successful DW-MRI were included in the study. The numbers of tumour subtypes were 47 for adenocarcinoma and 46 for squamous cell carcinoma. There was a good negative correlation between ADCmin values and the Ki-67 proliferation index (r = −0.837, p < 0.001). The mean ADCmin value was higher and the mean Ki-67 index was lower in adenocarcinomas compared to squamous cell carcinoma (p < 0.0001). There was no statistical difference between tissue sampling methods. Conclusions. Because ADCmin shows a good but negative correlation with Ki-67 index, it provides an opportunity to evaluate tumours and their aggressiveness and may be helpful in the differentiation of subtypes non-invasively.

Comparison of Histological and Proliferation Features of Canine Oral Squamous Cell Carcinoma Based on Intraoral Location: 36 Cases

2017 ◽  
Vol 34 (2) ◽  
pp. 92-99 ◽  
Author(s):  
Lisa A. Mestrinho ◽  
Hugo Pissarra ◽  
Sandra Carvalho ◽  
Maria C. Peleteiro ◽  
Jerzy Gawor ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Staging ◽  
Treatment Strategies ◽  
Nuclear Antigen ◽  
Proliferation Index ◽  
Ki 67 ◽  
Proliferation Markers

Grade and labeling indices for immunohistochemical tumor proliferation markers Ki-67 and proliferating cell nuclear antigen (PCNA) were evaluated in 36 cases of canine oral squamous cell carcinoma (OSCC) based upon intraoral location. Grade was significantly associated with location ( P = .035). Grade II tumors were most frequently diagnosed. Grade I tumors were identified in the gingiva and the buccal mucosa, and grade III tumors were seen in the gingiva and the tonsillar region. Animals with tumors arising from the tonsils and of the tongue tended to be older ( P = .007), and those in the former group were more likely to have metastatic disease at the time of diagnosis ( P = .001). Mean expression of PCNA and Ki-67 proliferation index (PI) for all tumors were 62.54% and 50.70%, respectively, and there was a statistical significant association between the 2 variables ( R = .70; P < .001). Proliferation index was not associated with any of the intraoral locations evaluated, but higher PCNA PI was significantly associated with grade ( P = .031). Ki-67 PI was significantly associated with lymph node metastasis at the time of diagnosis, especially for OSCC of gingival location ( P = .028). The results obtained in this study are preliminary but clinically relevant, since they provide information that can explain differences in biologic behavior among intraoral locations and contribute to more accurate tumor staging to support the choice for different treatment strategies available for OSCC.

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