Analysis of Human Immune Response against Salivary Glands Protein Extract of Anopheles sundaicus. L in Malaria Endemic Area

Abstract The mosquito species Ae. aegyptiand Ae. albopictusare two potential vectors of dengue fever. The salivary glands of these species contain substances that play a role in the transmission of pathogens. These include vasodilators and immunomodulatory compounds. Immunomodulatory components can modulate the host immune system by producing specific antibodies (IgG). This study aims to investigate the human immune response (IgG) against the salivary gland extract of Ae. aegyptiand Ae. albopictus. Samples were collected from individuals who were Dengue patients, as well as healthy individuals and neonates from the Jember endemic area. Results show that the levels of IgG response vary across the individual. Generally, Dengue patients and healthy people in the DHF-endemic area had higher levels of IgG. The highest immune response was found in DHF patients, followed by healthy persons, and finally the neonate samples, respectively.

Download Full-text

Assessing the human immune response to SARS-CoV-2 variants

Nature Medicine ◽

10.1038/s41591-021-01290-0 ◽

2021 ◽

Vol 27 (4) ◽

pp. 571-572 ◽

Cited By ~ 1

Author(s):

Roberto Burioni ◽

Eric J. Topol

Keyword(s):

Immune Response ◽

Human Immune Response ◽

Human Immune

Download Full-text

Approaches to Modelling the Human Immune Response in Transition of Candidates from Research to Development

Journal of Immunology Research ◽

10.1155/2014/395302 ◽

2014 ◽

Vol 2014 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Diane Williamson

Keyword(s):

Immune Response ◽

Human Immune Response ◽

Human Immune ◽

Animal Rule

This review considers the steps required to evaluate a candidate biodefense vaccine or therapy as it emerges from the research phase, in order to transition it to development. The options for preclinical modelling of efficacy are considered in the context of the FDA’s Animal Rule.

Download Full-text

Molecular characterization of Treponema pallidum proteins responsible for the human immune response to syphilis

Antonie van Leeuwenhoek ◽

10.1007/bf00448422 ◽

1982 ◽

Vol 48 (5) ◽

pp. 486-487 ◽

Cited By ~ 7

Author(s):

R. V. W. van Eijk ◽

J. D. A. van Embden

Keyword(s):

Immune Response ◽

Molecular Characterization ◽

Treponema Pallidum ◽

Human Immune Response ◽

Human Immune

Download Full-text

The effects of anabolic steroids and strength training on the human immune response

Medicine & Science in Sports & Exercise ◽

10.1249/00005768-198908000-00008 ◽

1989 ◽

Vol 21 (4) ◽

pp. 386???392 ◽

Cited By ~ 30

Author(s):

LEONARD H. CALABRESE ◽

SUSAN M. KLEINER ◽

BARBARA P. BARNA ◽

CHRISTINE I. SKIBINSKI ◽

DONALD T. KIRKENDALL ◽

...

Keyword(s):

Immune Response ◽

Strength Training ◽

Anabolic Steroids ◽

Human Immune Response ◽

Human Immune

Download Full-text

The human immune response to Mycobacterium tuberculosis in lung and lymph node

Journal of Theoretical Biology ◽

10.1016/j.jtbi.2003.11.023 ◽

2004 ◽

Vol 227 (4) ◽

pp. 463-486 ◽

Cited By ~ 97

Author(s):

Simeone Marino ◽

Denise E. Kirschner

Keyword(s):

Immune Response ◽

Mycobacterium Tuberculosis ◽

Lymph Node ◽

Human Immune Response ◽

Human Immune

Download Full-text

Development of A First-Responder Fluorescence Reader for Microarray Cytokine Assay of Human Immune Response to Disease

MRS Proceedings ◽

10.1557/proc-1004-p03-26 ◽

2007 ◽

Vol 1004 ◽

Author(s):

David B. Fenner ◽

David I Rosen ◽

Anthony A Ferrante ◽

Amy E Stevens ◽

Chad E Bigelow ◽

...

Keyword(s):

Immune Response ◽

Image Analysis ◽

Optical Design ◽

Human Saliva ◽

Minimally Processed ◽

Portable Apparatus ◽

New Apparatus ◽

Human Immune Response ◽

Human Immune ◽

Cytokine Assay

AbstractDevelopment of field portable apparatus and methods for cytokine assay of human saliva by fluorescent-reporting microarray plates is described. Multiplexed assay of 12 cytokines for minimally-processed saliva is read with a CCD-based imager under LED excitation. Immune responsive cytokines are measured at levels significant for indication of human disease state. The motivational context for the new apparatus development, the general optical design issues, saliva protocol, and image analysis are described.

Download Full-text