scholarly journals In vitro analysis of human immune response (IgG) against salivary gland extract of dengue vector from dengue hemorrhagic fever (DHF) endemic area in Jember, Indonesia

2021 ◽  
Vol 913 (1) ◽  
pp. 012090
Author(s):  
R Oktarianti ◽  
D R Damara ◽  
S U R Qudsiyah ◽  
S Wathon ◽  
K Senjarini
Keyword(s):  
Immune Response ◽  
Salivary Gland ◽  
Endemic Area ◽  
Mosquito Species ◽  
Host Immune System ◽  
Salivary Gland Extract ◽  
Gland Extract ◽  
Human Immune Response ◽  
Human Immune

Abstract The mosquito species Ae. aegyptiand Ae. albopictusare two potential vectors of dengue fever. The salivary glands of these species contain substances that play a role in the transmission of pathogens. These include vasodilators and immunomodulatory compounds. Immunomodulatory components can modulate the host immune system by producing specific antibodies (IgG). This study aims to investigate the human immune response (IgG) against the salivary gland extract of Ae. aegyptiand Ae. albopictus. Samples were collected from individuals who were Dengue patients, as well as healthy individuals and neonates from the Jember endemic area. Results show that the levels of IgG response vary across the individual. Generally, Dengue patients and healthy people in the DHF-endemic area had higher levels of IgG. The highest immune response was found in DHF patients, followed by healthy persons, and finally the neonate samples, respectively.

scholarly journals The Human Immune Response to Respiratory Syncytial Virus Infection

2017 ◽  
Vol 30 (2) ◽  
pp. 481-502 ◽  
Author(s):  
Clark D. Russell ◽  
Stefan A. Unger ◽  
Marc Walton ◽  
Jürgen Schwarze
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
T Cell ◽  
T Cell Response ◽  
Rsv Infection ◽  
Human Immune Response ◽  
Ifn Γ ◽  
Human Immune ◽  
Syncytial Virus

SUMMARY Respiratory syncytial virus (RSV) is an important etiological agent of respiratory infections, particularly in children. Much information regarding the immune response to RSV comes from animal models and in vitro studies. Here, we provide a comprehensive description of the human immune response to RSV infection, based on a systematic literature review of research on infected humans. There is an initial strong neutrophil response to RSV infection in humans, which is positively correlated with disease severity and mediated by interleukin-8 (IL-8). Dendritic cells migrate to the lungs as the primary antigen-presenting cell. An initial systemic T-cell lymphopenia is followed by a pulmonary CD8+ T-cell response, mediating viral clearance. Humoral immunity to reinfection is incomplete, but RSV IgG and IgA are protective. B-cell-stimulating factors derived from airway epithelium play a major role in protective antibody generation. Gamma interferon (IFN-γ) has a strongly protective role, and a Th2-biased response may be deleterious. Other cytokines (particularly IL-17A), chemokines (particularly CCL-5 and CCL-3), and local innate immune factors (including cathelicidins and IFN-λ) contribute to pathogenesis. In summary, neutrophilic inflammation is incriminated as a harmful response, whereas CD8+ T cells and IFN-γ have protective roles. These may represent important therapeutic targets to modulate the immunopathogenesis of RSV infection.

Parvovirus H-1-Induced Tumor Cell Death Enhances Human Immune Response In Vitro via Increased Phagocytosis, Maturation, and Cross-Presentation by Dendritic Cells

2005 ◽  
Vol 0 (0) ◽  
pp. 050701034702004
Author(s):  
Markus H. Moehler ◽  
Maja Zeidler ◽  
Vanessa Wilsberg ◽  
Jan J. Cornelis ◽  
Thomas Woelfel ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Dendritic Cells ◽  
Tumor Cell ◽  
Tumor Cell Death ◽  
Cross Presentation ◽  
Human Immune Response ◽  
Human Immune ◽  
Immune Response In Vitro

Parvovirus H-1-Induced Tumor Cell Death Enhances Human Immune Response In Vitro via Increased Phagocytosis, Maturation, and Cross-Presentation by Dendritic Cells

2005 ◽  
Vol 0 (0) ◽  
pp. 050719131035001
Author(s):  
Markus H. Moehler ◽  
Maja Zeidler ◽  
Vanessa Wilsberg ◽  
Jan J. Cornelis ◽  
Thomas Woelfel ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Dendritic Cells ◽  
Tumor Cell ◽  
Tumor Cell Death ◽  
Cross Presentation ◽  
Human Immune Response ◽  
Human Immune ◽  
Immune Response In Vitro

Hyalomma dromedarii (Acari: Ixodidae) Salivary Gland Extract Inhibits Angiogenesis and Exhibits In Vitro Antitumor Effects

2017 ◽  
Vol 54 (6) ◽  
pp. 1476-1482 ◽  
Author(s):  
Chaima Bensaoud ◽  
Zaineb Abdelkafi-Koubaa ◽  
Hazem Ben Mabrouk ◽  
Maram Morjen ◽  
Issam Hmila ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Hyalomma Dromedarii ◽  
Salivary Gland Extract ◽  
Antitumor Effects ◽  
Gland Extract

Analysis of Human Immune Response against Salivary Glands Protein Extract of Anopheles sundaicus. L in Malaria Endemic Area

2017 ◽  
Vol 11 (1) ◽  
pp. 23-27
Author(s):  
MOHAMMAD MIRZA NURYADY ◽  
◽  
SUGENG SEYO UTOMO ◽  
YUNITA ARMIYANTI ◽  
SRI MUMPUNI WAHYU WIDJAJATI ◽  
...  
Keyword(s):  
Immune Response ◽  
Salivary Glands ◽  
Endemic Area ◽  
Malaria Endemic Area ◽  
Protein Extract ◽  
Human Immune Response ◽  
Human Immune

scholarly journals Clostridium difficile toxins A and B inhibit human immune response in vitro.

1988 ◽  
Vol 56 (5) ◽  
pp. 1107-1112 ◽  
Author(s):  
W Däubener ◽  
E Leiser ◽  
C von Eichel-Streiber ◽  
U Hadding
Keyword(s):  
Immune Response ◽  
Clostridium Difficile ◽  
Human Immune Response ◽  
Human Immune ◽  
Immune Response In Vitro

HUMAN IMMUNOGLOBULINS—A GUIDE TO NOMENCLATURE AND CLINICAL APPLICATION

PEDIATRICS ◽  
1966 ◽  
Vol 37 (5) ◽  
pp. 822-827
Author(s):  
Richard T. Smith
Keyword(s):  
Immune Response ◽  
Health It ◽  
Technical Literature ◽  
Biologic Effects ◽  
Human Immune Response ◽  
The Subject ◽  
Human Immune ◽  
Ig G ◽  
Structure And Functions

THE MULTIFOLD character of the human immune response has been recognized for many years by the variety of antibodies which result from infection or immunization. Until recently, the basis for such discrimination has been limited to the electrophoretic mobility or biologic effects of antibody in vitro. Biophysical tools which permit the isolation and structural investigation of proteins and other macromolecules have been applied to antibody molecules with such effectiveness that it is now possible to describe the heterogeneity of the human immune response in exquisite detail. These major advances in knowledge require and justify an updated nomenclature. THE NOMENCLATURE A group of leaders in this field met in 1964 at Geneva under the auspices of WHO and recommended international adoption of the terms shown in Table I A-1. The preexisting confusion over nomenclature appears to have been resolved by nearly unanimous adoption of their recommendations by workers in the field with the result that it is standard in most current technical literature on the subject. Popular usage to date appears to favor the notation employing the Greek letter gamma: γG, γM, γA, and γD for the major classes of immunoglobulins, rather than the equally acceptable, but phonetically clumsy Ig-G, Ig-M, Ig-A, and Ig-D notation. Because the data involved, as well as the nomenclature, are too new to have appeared in textbooks or review journals usually read by those interested in child health, it is appropriate to review briefly the structure and functions of the immunoglobulin molecules as currently understood, and to suggest some actual and potentially important applications of this information in diagnosis and therapy.

scholarly journals Human immune response to Phlebotomus sergenti salivary gland antigens in a leishmaniasis-endemic focus in Iran

2020 ◽  
Vol 114 (6) ◽  
pp. 323-332
Author(s):  
Arshad Veysi ◽  
Ahmad Reza Mahmoudi ◽  
Mohammad Reza Yaghoobi-Ershadi ◽  
Mahmood Jeddi-Tehrani ◽  
Yavar Rassi ◽  
...  
Keyword(s):  
Immune Response ◽  
Salivary Gland ◽  
Endemic Focus ◽  
Phlebotomus Sergenti ◽  
Human Immune Response ◽  
Human Immune
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