scholarly journals Enumerating pelvic recurrence following radical cystectomy for bladder cancer: A Canadian multi-institutional study

2016 ◽  
Vol 10 (3-4) ◽  
pp. 90 ◽  
Author(s):  
Libni J. Eapen ◽  
Edward Jones ◽  
Wassim Kassouf ◽  
Carole Lambert ◽  
Scott C. Morgan ◽  
...  
Keyword(s):  
Radical Cystectomy ◽  
Urothelial Cancer ◽  
Clinical Status ◽  
High Rate ◽  
Pelvic Recurrence ◽  
Entire Group ◽  
Tumour Stage ◽  
Patterns Of Failure ◽  
Node Negative ◽  
Pelvic Relapse

<p><strong>Introduction:</strong> We aimed to enumerate the rate of pelvic recurrence following radical cystectomy at university-affiliated hospitals in Canada.</p><p><strong>Methods:</strong> Canadian, university-affiliated hospitals were invited to participate. They were asked to identify the first 10 consecutive patients undergoing radical cystectomy starting January 1, 2005, who had urothelial carcinoma stages pT3/T4 N0-2 M0. The first 10 consecutive cases starting January 1, 2005 who met these criteria were the patients submitted by that institution with information regarding tumour stage, age, number of nodes removed, and last known clinical status in regard to recurrence and patterns of failure.</p><p><strong>Results:</strong> Of the 111 patients, 80% had pT3 and 20% pT4 disease, with 62% being node-negative, 14% pN1, and 27% pN2; 57% had 10 or more nodes removed. Cumulative incidence of pelvic relapse was 40% among the entire group</p><p><strong>Conclusions:</strong> This review demonstrates a high rate of pelvic tumour recurrence following radical cystectomy for pT3/T4 urothelial cancer.</p>

1258: Utility of Assessment of Ureteral Margins during Radical Cystectomy for Urothelial Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 404-405
Author(s):  
Ranaan Tal ◽  
Ganesh V. Raj ◽  
Bernard H. Boehner ◽  
Angel Serio ◽  
Andrew J. Vickers ◽  
...  
Keyword(s):  
Radical Cystectomy ◽  
Urothelial Cancer

MP61-20 PELVIC RECURRENCE FOLLOWING RADICAL CYSTECTOMY AND ITS IMPACT ON BLADDER CANCER OUTCOMES

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Anirban P. Mitra ◽  
Anne K. Schuckman ◽  
Eila C. Skinner ◽  
Siamak Daneshmand
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Pelvic Recurrence ◽  
Cancer Outcomes

Surgical Management of Mitral Regurgitation After Repair of Endocardial Cushion Defects

Circulation ◽  
2000 ◽  
Vol 102 (suppl_3) ◽  
Author(s):  
Adrian M. Moran ◽  
Sabine Daebritz ◽  
John F. Keane ◽  
John E. Mayer
Keyword(s):  
Mitral Valve ◽  
Mitral Regurgitation ◽  
Valve Replacement ◽  
Clinical Status ◽  
Postoperative Mortality ◽  
Heart Association ◽  
Morphological Type ◽  
Early Postoperative Period ◽  
High Rate ◽  
Mitral Valve Operation

Background —Mitral regurgitation (MR) represents the principal indication for reoperation in patients after repair of atrioventricular septal defects (AVSD). Reports of mitral valvuloplasty (MVP) in such patients are few; the alternative, mitral valve replacement (MVR), necessitates commitment to future valve replacement and long-term anticoagulation. We sought to determine the outcome of those patients who underwent either MVP or MVR between January 1, 1988, and December 31, 1998, for significant MR after repair of AVSD. Furthermore, we sought to identify (a) morphological predictors necessitating MVR, and (b) predictors of future reoperation within the MVP group. Methods and Results —Retrospective review of clinical, operative, and echocardiographic data were performed. There were 46 patients identified (37 MVP and 9 MVR). The median age at initial AVSD repair was 0.6 years, and the age at subsequent mitral valve operation was 2.8 years. The early postoperative mortality rate was 2.2%, and survival at 1 and 10 years was 89.9% and 86.6%, respectively. A high rate of complete heart block was noted within the MVR group (37.5%). Freedom from later mitral valve reoperation for both groups was similar. No significant morphological predictors necessitating MVR were found. Predictors of reoperation within the MVP group included the presence of moderate or worse MR in the early postoperative period. In both groups New York Heart Association class, degree of MR, growth, and ventricular volumes improved. Conclusions —Mitral valve surgery significantly improves clinical status, with a sustained improvement in ventricular chamber size. MR can be successfully managed in patients after repair of AVSD independent of morphological type. Overall survival is acceptable, and further reoperation within the MVP group is influenced by early outcome of repair.

Prediction of prognosis after radical cystectomy for pathologic node-negative bladder cancer

2011 ◽  
Vol 43 (4) ◽  
pp. 1059-1065 ◽  
Author(s):  
Eun Park ◽  
Hong Koo Ha ◽  
Moon Kee Chung
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Node Negative ◽  
Prediction Of Prognosis

scholarly journals Predictors of Outcome of Non–Muscle-Invasive and Muscle-Invasive Bladder Cancer

2011 ◽  
Vol 11 ◽  
pp. 369-381 ◽  
Author(s):  
Ramy F. Youssef ◽  
Yair Lotan
Keyword(s):  
Bladder Cancer ◽  
Radical Cystectomy ◽  
Predictive Accuracy ◽  
Staging System ◽  
Tumor Grade ◽  
Invasive Disease ◽  
Tnm Staging ◽  
High Rate ◽  
Recurrence Rates ◽  
Muscle Invasive

Bladder cancer is a major cause of morbidity and mortality. At initial diagnosis, 75% of patients present with non–muscle-invasive disease and 25% of patients have muscle-invasive or metastatic disease.Patients with noninvasive disease suffer from a high rate of recurrence and 10–30% will have disease progression. Patients with muscle-invasive disease are primarily treated with radical cystectomy, but frequently succumb to their disease despite improvements in surgical technique. In non–muscle-invasive disease, multiplicity, tumor size, and prior recurrence rates are the most important predictors for recurrence, while tumor grade, stage, and carcinomain situare the most important predictors for progression. The most common tool that clinicians use to predict outcomes after radical cystectomy is still the tumor-node-metastasis (TNM) staging system, with lymph node involvement representing the most important prognostic factor. However, the predictive accuracy of staging and grading systems are limited, and nomograms incorporating clinical and pathologic factors can improve prediction of bladder cancer outcomes. One limitation of current staging is the fact that tumors of a similar stage and grade can have significantly different biology. The integration of molecular markers, especially in a panel approach, has the potential to further improve the accuracy of predictive models and may also identify targets for therapeutic intervention or patients who will respond to systemic therapies.

Pelvic Radiation Improves Local Control After Hysterectomy for Uterine Leiomyosarcoma: A 20-Year Experience

2009 ◽  
Vol 19 (6) ◽  
pp. 1080-1084 ◽  
Author(s):  
Ali Mahdavi ◽  
Bradley J. Monk ◽  
Jennifer Ragazzo ◽  
Mark I. Hunter ◽  
Scot E. Lentz ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
High Rate ◽  
Entire Group ◽  
Adjuvant Radiation ◽  
Uterine Leiomyosarcoma ◽  
Modest Improvement ◽  
Adjuvant Radiation Therapy

Background:Uterine leiomyosarcoma (LMS) is associated with high rate of recurrence after surgical resection. The role of adjuvant radiation therapy in improving survival in women with uterine LMS is unclear.Methods:All cases of LMS treated from 1985 to 2005 at 11 regional medical centers were identified. Kaplan-Meier survival curves were constructed and compared with log-rank testing. Multivariate analysis was performed to account for the potential influence of confounding factors.Results:One hundred forty-seven patients with LMS were identified. The median age of diagnosis was 51 years with the stage distribution of stage I (n = 87), II (n = 9), III (n = 25), IV (n = 25), and unknown (n = 1). One hundred forty-three underwent total abdominal hysterectomy and bilateral salpingoophorectomy. Twenty-four (17%) of these patients received adjuvant pelvic irradiation, and 63 (44%) received adjuvant and/or palliative chemotherapy. With a median follow-up of 24 months (range, 1-249 months), the median survival for the entire group was 37 months. Cox proportional hazards modeling demonstrated the presence of high tumor grade and advanced stage adversely affected survival. Although the 5-year survival for patients who received adjuvant radiotherapy was significantly higher than those who did not (70% vs 35%), this survival advantage was not sustained as the curves crossed at 90-month follow-up. Pelvic recurrence rate was lower in the radiation group (18% vs 49%; P = 0.02).Conclusions:Adjuvant radiation therapy was associated with decreased pelvic failure and a modest improvement in 5-year survival, but did not impact overall survival with extended follow-up.

Initial experience assessing pre-operative frailty with patients undergoing radical cystectomy for urothelial cancer

2013 ◽  
Vol 217 (3) ◽  
pp. S146-S147
Author(s):  
Louis Michael Revenig ◽  
Caroline G. Tai ◽  
Maxwell Douglas Taylor ◽  
Viraj A. Master ◽  
Kenneth Ogan ◽  
...  
Keyword(s):  
Radical Cystectomy ◽  
Urothelial Cancer ◽  
Initial Experience

Lymphovascular invasion is an independent predictor of oncological outcomes in patients with lymph node-negative urothelial bladder cancer treated by radical cystectomy: a multicentre validation trial

2010 ◽  
Vol 106 (4) ◽  
pp. 493-499 ◽  
Author(s):  
Christian Bolenz ◽  
Edwin Herrmann ◽  
Patrick J. Bastian ◽  
Maurice S. Michel ◽  
Christian Wülfing ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Radical Cystectomy ◽  
Lymphovascular Invasion ◽  
Independent Predictor ◽  
Urothelial Bladder Cancer ◽  
Node Negative ◽  
Oncological Outcomes ◽  
Urothelial Bladder
Sign in / Sign up

Export Citation Format

Share Document