scholarly journals Naked DNA in cells: An inducer of major histocompatibility complex molecules to evoke autoimmune responses?

2016 ◽  
Vol 5 (1) ◽  
pp. 46
Author(s):  
Yuqian Luo ◽  
Aya Yoshihara ◽  
Kenzaburo Oda ◽  
Yuko Ishido ◽  
Naoki Hiroi ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Complex Molecules ◽  
Naked Dna ◽  
Histocompatibility Complex ◽  
In Cells

scholarly journals The Role of Peptides in T Cell Alloreactivity Is Determined by Self–Major Histocompatibility Complex Molecules

2000 ◽  
Vol 191 (5) ◽  
pp. 805-812 ◽  
Author(s):  
Reinhard Obst ◽  
Nikolai Netuschil ◽  
Karsten Klopfer ◽  
Stefan Stevanović ◽  
Hans-Georg Rammensee
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
T Cell ◽  
Target Cells ◽  
Major Histocompatibility ◽  
Complex Molecules ◽  
Mhc Molecules ◽  
Histocompatibility Complex ◽  
Alloreactive T Cells

By analyzing T cell responses against foreign major histocompatibility complex (MHC) molecules loaded with peptide libraries and defined self- and viral peptides, we demonstrate a profound influence of self-MHC molecules on the repertoire of alloreactive T cells: the closer the foreign MHC molecule is related to the T cell's MHC, the higher is the proportion of peptide-specific, alloreactive (“allorestricted”) T cells versus T cells recognizing the foreign MHC molecule without regard to the peptide in the groove. Thus, the peptide repertoire of alloreactive T cells must be influenced by self-MHC molecules during positive or negative thymic selection or peripheral survival, much like the repertoire of the self-restricted T cells. In consequence, allorestricted, peptide-specific T cells (that are of interest for clinical applications) are easier to obtain if T cells and target cells express related MHC molecules.

scholarly journals Human Herpesvirus 7 U21 Tetramerizes To Associate with Class I Major Histocompatibility Complex Molecules

2014 ◽  
Vol 88 (6) ◽  
pp. 3298-3308 ◽  
Author(s):  
N. A. May ◽  
Q. Wang ◽  
A. Balbo ◽  
S. L. Konrad ◽  
R. Buchli ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Human Herpesvirus ◽  
Class I ◽  
Major Histocompatibility ◽  
Complex Molecules ◽  
Histocompatibility Complex
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